scholarly journals A functional variant at miRNA-122 binding site in IL-1α 3′ UTR predicts risk and HPV-positive tumours of oropharyngeal cancer

2015 ◽  
Vol 51 (11) ◽  
pp. 1415-1423 ◽  
Author(s):  
Yang Zhang ◽  
Erich M. Sturgis ◽  
Yan Sun ◽  
Chuanzheng Sun ◽  
Qingyi Wei ◽  
...  
Keyword(s):  
Binding Site ◽  
Oropharyngeal Cancer ◽  
Functional Variant

scholarly journals A functional variant at miRNA-122 binding site in IL-1α 3′ UTR predicts risk of recurrence in patients with oropharyngeal cancer

Oncotarget ◽  
2016 ◽  
Vol 7 (23) ◽  
pp. 34472-34479 ◽  
Author(s):  
Chengyuan Wang ◽  
Erich M. Sturgis ◽  
Xingming Chen ◽  
Qingyi Wei ◽  
Guojun Li
Keyword(s):  
Binding Site ◽  
Oropharyngeal Cancer ◽  
Risk Of Recurrence ◽  
Functional Variant

scholarly journals A functional variant at the miR-184 binding site in TNFAIP2 and risk of squamous cell carcinoma of the head and neck

2011 ◽  
Vol 32 (11) ◽  
pp. 1668-1674 ◽  
Author(s):  
Zhensheng Liu ◽  
Sheng Wei ◽  
Hongxia Ma ◽  
Mei Zhao ◽  
Jeffrey N. Myers ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Binding Site ◽  
Squamous Cell ◽  
Functional Variant

scholarly journals A functional variant rs12904 in the miR-200c binding site was associated with a decreased risk of ischemic stroke

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Zhi-Neng Zeng ◽  
Ling-Ling Liu ◽  
Yong-Ling He ◽  
Xiang Shi ◽  
Ye-Sheng Wei
Keyword(s):  
Ischemic Stroke ◽  
Binding Site ◽  
Functional Variant

scholarly journals A Functional Variant at the miR-214 Binding Site in the Methylenetetrahydrofolatereductase Gene Alters Susceptibility to Gastric Cancer in a Chinese Han Population

2015 ◽  
Vol 36 (2) ◽  
pp. 622-630 ◽  
Author(s):  
Qiaoyun Chen ◽  
Rong Qin ◽  
Yue Fang ◽  
Hao Li ◽  
Yangchen Liu
Keyword(s):  
Gastric Cancer ◽  
Binding Site ◽  
Cancer Patients ◽  
Binding Sites ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Increased Risk ◽  
Functional Variant ◽  
Gastric Cancer Patients

Background and Aims: Single nucleotide polymorphisms in miRNA binding sites, which are located in mRNA 3' untranslated regions (3'-UTRs), were recently found to influence microRNA-target interactions. Specifically, such polymorphisms can modulatebinding affinity or create or destroy miRNA-binding sites; such variants have also been found to be associated with cancer risk. In this study, we explored the effect of a functional variant at the miR-214 binding site in the methylenetetrahydrofolate reductase gene (rs114673809) on gastric cancer (GC) risk in a hospital-based case-control study in a Chinese Han population. Methods and Results: We genotyped the rs114673809 polymorphism in 345 gastric cancer patients and 376 cancer-free controls using the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) technique. The functions of rs114673809 were investigated using a luciferase activity assay and validated by immunoblotting. We found that participants carrying the rs114673809 AA genotype or A allele had a significantly increased risk of gastric cancer (OR = 1.667, 95% CI = 1.044-2.660, P = 0.034; OR = 1.261, 95% CI = 1.017-1.563, P = 0.037, respectively) compared to those carrying the GG genotype and G allele. In addition, rs114673809 modified the binding of hsa-miR-214 to MTHFR as well as MTHFR protein levels in gastric cancer patients. Conclusion: Our data suggested that rs114673809, which is located at the miR-214 binding site in the 3'-UTR of MTHFR, may play an important role in the development of gastric cancer in a Chinese Han population.

Functional polymorphism in the microRNA-367 binding site as a prognostic factor for colonic cancer.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e14549-e14549
Author(s):  
Yee Soo Chae ◽  
Soo Jung Lee ◽  
Jong Gwang Kim ◽  
Byung Woog Kang ◽  
Yoo Jin Lee ◽  
...  
Keyword(s):  
Binding Site ◽  
Binding Sites ◽  
Target Genes ◽  
Receptor Gene ◽  
Univariate Analysis ◽  
Recessive Model ◽  
Curative Surgery ◽  
Potential Marker ◽  
Functional Variant ◽  
Fresh Frozen

e14549 Background: As microRNAs play important roles in cancer development and progression by regulating the expressions of oncogenes and tumor suppressor genes though interacting with the 3′ untranslated region (UTR) of target genes, we aimed to evaluate the association between genetic variants of miRNAs and their binding sites and prognosis in patients with colorectal cancer (CRC). Methods: Three miRNA variants and four variants in the miRNA binding sites were selected based on allelic frequencies and potential impact described in previous studies. DNA was extracted from fresh-frozen tissues of 344 patients with CRC who underwent curative surgery and genotyping analyses were performed using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. Results: Among seven target variants, rs1044129 at the miR-367 binding site of calcium channel ryanodine receptor gene 3 (RYR3) was associated with relapse-free survival (RFS) for colon cancer patients as a recessive model in a univariate analysis. Moreover, a multivariate analysis revealed that patients carrying the GG genotype had poor RFS compared to those with the AA or AG genotype (hazard ratio, HR=2.864; p=0.005), yet there was only a marginal trend for disease-specific survival (HR=2.226; p=0.087) regardless of the patient and tumor characteristics. Conclusions: The current study suggests that the functional variant (rs1044129) in the miR-367 binding site of RYR3 may be a potential marker for prognosis in patients after curative surgery for CRC.

A functional variant in SLC1A3 influences ADHD risk by disrupting a hsa‐miR‐3171 binding site: A two‐stage association study

2019 ◽  
pp. e12574 ◽  
Author(s):  
Xin Huang ◽  
Qi Zhang ◽  
Xinzhen Chen ◽  
Xue Gu ◽  
Min Wang ◽  
...  
Keyword(s):  
Association Study ◽  
Binding Site ◽  
Two Stage ◽  
Functional Variant

scholarly journals A genetic variant within MDM4 3′UTR miRNA binding site is associated with HPV16‐positive tumors and survival of oropharyngeal cancer

2019 ◽  
Vol 58 (12) ◽  
pp. 2276-2285 ◽  
Author(s):  
Yang Zhang ◽  
Erich M. Sturgis ◽  
Peng Wei ◽  
Hongliang Liu ◽  
Ziqiao Wang ◽  
...  
Keyword(s):  
Binding Site ◽  
Oropharyngeal Cancer ◽  
Genetic Variant ◽  
Mirna Binding Site
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