scholarly journals Developing Insulin Delivery Devices with Glucose Responsiveness

2021 ◽  
Vol 42 (1) ◽  
pp. 31-44
Author(s):  
Zejun Wang ◽  
Jinqiang Wang ◽  
Anna R. Kahkoska ◽  
John B. Buse ◽  
Zhen Gu
Keyword(s):  
Insulin Delivery ◽  
Glucose Responsiveness

scholarly journals Glucose - Responsive Smart Insulin

2018 ◽  
Vol 54 (02) ◽  
pp. 064-073
Author(s):  
Aishwarya Krishnamurthy ◽  
Ravinder Goswami
Keyword(s):  
Blood Glucose ◽  
Closed Loop ◽  
Insulin Delivery ◽  
Glucose Levels ◽  
The Third ◽  
Blood Glucose Levels ◽  
Analog Systems ◽  
Second Category ◽  
Glucose Responsiveness

ABSTRACTThe discovery of insulin in 1920s revolutionized the management of Type 1 Diabetes Mellitus. The evolution of insulin over the last nine decades has seen three phases, namely discovery and understanding of the molecule, advances in synthesis of the molecule and advancements in the optimization of insulin structure and delivery. These advances aim to minimize hypoglycemia while simultaneously improving anti-hyperglycemic efficacy. Glucose-responsive insulin (GRI) systems were first conceptualized in 1979. These are novel insulin formulations that provide anti hyperglycemic activity appropriate to circulating glucose levels but with a mechanism to avoid hypoglycemia, that often accompanies stringent glycemic control. GRIs are of three major typesalgorithm-based mechanical, polymer-based, molecular GRI analog systems. They differ in the mechanisms of achieving glucose responsiveness. Algorithm-based systems are closed loop insulin pumps that adjust insulin delivery commensurate with blood glucose levels on the basis of predetermined algorithms, that terminate or increase insulin delivery according to blood glucose trends. The second category of GRI includes glucose-responsive polymer-based matrices that house insulin, releasing insulin as needed based on ambient glucose levels. The third approach is to incorporate glucose sensitive motifs in the insulin molecule itself that would decrease or increase insulin availability based on blood glucose levels. The mechanisms behind these novel approaches to insulin delivery and action will be the focus of this review article.

1065-P: The Effect of a Closed-Loop Insulin Delivery System on Glycemic Control in Type 1 Diabetes

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1065-P ◽  
Author(s):  
ANASTASIOS KOUTSOVASILIS ◽  
ALEXIOS SOTIROPOULOS ◽  
ANASTASIA ANTONIOU ◽  
VASILIOS KORDINAS ◽  
DESPINA PAPADAKI ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Delivery System ◽  
Closed Loop ◽  
Insulin Delivery ◽  
Insulin Delivery System

User- and Health Care Provider–Reported Outcomes for a Wearable Bolus Insulin Delivery Patch

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 995-P
Author(s):  
MARK PEYROT ◽  
RICHARD M. BERGENSTAL ◽  
DARLENE M. DREON ◽  
VANITA ARODA ◽  
TIMOTHY S. BAILEY ◽  
...  
Keyword(s):  
Health Care ◽  
Health Care Provider ◽  
Care Provider ◽  
Insulin Delivery ◽  
Bolus Insulin

Comparing Patch vs. Pen Bolus Insulin Delivery in Type 2 Diabetes Using Continuous Glucose Monitoring Metrics and Profiles

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 73-LB
Author(s):  
MARY L. JOHNSON ◽  
DARLENE M. DREON ◽  
BRIAN L. LEVY ◽  
SARA RICHTER ◽  
DEBORAH MULLEN ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Continuous Glucose Monitoring ◽  
Glucose Monitoring ◽  
Insulin Delivery ◽  
Bolus Insulin

725-P: Reducing Hypoglycemic Risk during Postprandial Exercise with Closed-Loop Insulin Delivery in Adults with Type 1 Diabetes: Announced and Unannounced Exercise

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 725-P
Author(s):  
SEMAH TAGOUGUI ◽  
NADINE TALEB ◽  
CORINNE SUPPERE ◽  
INÈS BOUKABOUS ◽  
VIRGINIE MESSIER ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Closed Loop ◽  
Insulin Delivery

730-P: At-Home Randomized Crossover Comparison of Automated Insulin Delivery vs. Conventional Therapy with Scheduled Meal Challenges

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 730-P
Author(s):  
JORDAN E. PINSKER ◽  
SUNIL DESHPANDE ◽  
MEI MEI CHURCH ◽  
MOLLY PIPER ◽  
CAMILLE C. ANDRE ◽  
...  
Keyword(s):  
Conventional Therapy ◽  
Insulin Delivery ◽  
Crossover Comparison ◽  
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