Detection and quantification of glucuro- and sulfoconjugated metabolites in human urine following oral administration of xenobiotic 19-norsteroids

Steroids ◽  
2006 ◽  
Vol 71 (9) ◽  
pp. 817-827 ◽  
Author(s):  
Y.L. Tseng ◽  
C.-Y. Sun ◽  
F.-H. Kuo
Keyword(s):  
Oral Administration ◽  
Human Urine ◽  
Detection And Quantification

scholarly journals Review: Detection and quantification of proteins in human urine

Talanta ◽  
2021 ◽  
Vol 223 ◽  
pp. 121718
Author(s):  
Sultan Aitekenov ◽  
Abduzhappar Gaipov ◽  
Rostislav Bukasov
Keyword(s):  
Human Urine ◽  
Detection And Quantification

Effect of Pretreatment of Rats with an Urinary Preparation on Liver Injuries Induced by Carbon Tetrachloride and α-Naphthylisothiocyanate

1998 ◽  
Vol 26 (03n04) ◽  
pp. 343-351 ◽  
Author(s):  
Tung-Yuan Lai ◽  
Yueh-Wern Wu ◽  
Jaung-Geng Lin ◽  
Wen-Chuan Lin
Keyword(s):  
Lipid Peroxidation ◽  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Oral Administration ◽  
Human Urine ◽  
Acute Liver Injury ◽  
Indirect Pathway ◽  
Liver Injuries ◽  
Hepatic Glutathione ◽  
Biochemical Observation

The effect of oral administration of a preparation of human urine (PHU) on the progression of acute liver injury was examined in rats intoxicated with carbon tetrachloride (CCl4) and α-naphthylisothiocyanate (ANIT). PHU protected the liver from CCl4-induced injury as judged by morphological and biochemical observations. In contrast, PHU aggravated ANIT-induced injury as judged also by morphological and biochemical observation. PHU prevented the increase in hepatic glutathione (GSH) and lipid peroxidation induced by CCl4. But PHU enhanced the increase in hepatic GSH caused by ANIT. These results indicate that the effect of PHU on hepatic GSH concentrations is through an indirect pathway. Clinical application of PHU on hepatitis should be explored further.

Sign in / Sign up

Export Citation Format

Share Document