scholarly journals Moving Forward in Human Mammary Stem Cell Biology and Breast Cancer Prognostication Using ALDH1

2007 ◽  
Vol 1 (5) ◽  
pp. 485-487 ◽  
Author(s):  
Danuta Balicki
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cell Biology ◽  
Mammary Stem Cell ◽  
Stem Cell Biology ◽  
Mammary Stem

scholarly journals The future of mammary stem cell biology: the power of in vivo transplants

2008 ◽  
Vol 10 (3) ◽  
Author(s):  
Geoffrey J Lindeman ◽  
Jane E Visvader ◽  
Matthew J Smalley ◽  
Connie J Eaves
Keyword(s):  
Stem Cell ◽  
Cell Biology ◽  
Mammary Stem Cell ◽  
Stem Cell Biology ◽  
The Future ◽  
Mammary Stem

Translating Mammary Stem Cell and Cancer Stem Cell Biology to the Clinics

2011 ◽  
pp. 433-450
Author(s):  
Rajneesh Pathania ◽  
Vadivel Ganapathy ◽  
Muthusamy Thangaraju
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Biology ◽  
Mammary Stem Cell ◽  
Stem Cell Biology ◽  
Mammary Stem

scholarly journals Mammary-Stem-Cell-Based Somatic Mouse Models Reveal Breast Cancer Drivers Causing Cell Fate Dysregulation

Cell Reports ◽  
2016 ◽  
Vol 16 (12) ◽  
pp. 3146-3156 ◽  
Author(s):  
Zheng Zhang ◽  
John R. Christin ◽  
Chunhui Wang ◽  
Kai Ge ◽  
Maja H. Oktay ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cell Fate ◽  
Mouse Models ◽  
Mammary Stem Cell ◽  
Mammary Stem ◽  
Cancer Drivers

CD24 and CD49f expressions of E14.5 mouse mammary anlagen cells define putative distribution of earlier embryonic mammary stem cell activities

2018 ◽  
Vol 96 (5) ◽  
pp. 539-547 ◽  
Author(s):  
Jiazhe Song ◽  
Fangrong Ding ◽  
Song Li ◽  
Wenzhe Li ◽  
Ning Li ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mammary Gland ◽  
Cell Population ◽  
Cell Biology ◽  
Cell Activity ◽  
Mammary Stem Cell ◽  
Flow Cytometry Analysis ◽  
Large Numbers ◽  
Stem Cell Activity ◽  
Mammary Stem

Stem cell biology offers promise for understanding the origins of the mammary gland. However, the distribution of mammary stem cell (MaSC) activities at earlier embryonic stages has not been fully identified. The markers for sorting adult MaSC, CD24, CD29, and CD49f have been applied to analyze fetal MaSCs. Here we explored mammary anlagen MaSCs by investigating the expression of CD24 and CD49f. According to the comparative analysis between adult mammary gland and fetal mammary anlagen, we found that fetal mouse mammary anlagen may possess a high percentage of potential MaSCs. Flow cytometry analysis revealed 2 distinct mammary anlagen populations: Lin–CD24med and Lin–CD24high. Sphere-forming and mammary repopulating assays confirmed that the stem cell activity of E14.5 mouse mammary anlagen was restricted to the Lin–CD24med cell population. Furthermore, CD24med mammary anlagen cells were separated into Lin–CD24medCD49f+ and Lin–CD24medCD49f– populations and identified, respectively. The results proved that the mammary anlagen Lin–CD24medCD49f+ cell population possesses more stem cell activities than the Lin–CD24medCD49f– cell population. However, a limited numbers of stem cells and large numbers of stromal cells were identified in mammary anlagen in the Lin–CD24med cell population.

Abstract B47: Validation of novel breast cancer drivers using mammary stem cell-based somatic mouse models

2018 ◽  
Author(s):  
Zheng Zhang ◽  
John R. Christin ◽  
Chunhui Wang ◽  
Kai Ge ◽  
Maja Oktay ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Mouse Models ◽  
Mammary Stem Cell ◽  
Mammary Stem ◽  
Cancer Drivers

scholarly journals A Mammary Stem Cell Population Identified and Characterized in Late Embryogenesis Reveals Similarities to Human Breast Cancer

2012 ◽  
Vol 10 (2) ◽  
pp. 183-197 ◽  
Author(s):  
Benjamin T. Spike ◽  
Dannielle D. Engle ◽  
Jennifer C. Lin ◽  
Samantha K. Cheung ◽  
Justin La ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cell Population ◽  
Human Breast Cancer ◽  
Mammary Stem Cell ◽  
Stem Cell Population ◽  
Human Breast ◽  
Late Embryogenesis ◽  
Mammary Stem
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