scholarly journals Re-evaluation of mammary stem cell biology based on in vivotransplantation

2008 ◽  
Vol 10 (1) ◽  
Author(s):  
Gilbert H Smith ◽  
Daniel Medina
Keyword(s):  
Stem Cell ◽  
Cell Biology ◽  
Mammary Stem Cell ◽  
Stem Cell Biology ◽  
Mammary Stem

scholarly journals The future of mammary stem cell biology: the power of in vivo transplants

2008 ◽  
Vol 10 (3) ◽  
Author(s):  
Geoffrey J Lindeman ◽  
Jane E Visvader ◽  
Matthew J Smalley ◽  
Connie J Eaves
Keyword(s):  
Stem Cell ◽  
Cell Biology ◽  
Mammary Stem Cell ◽  
Stem Cell Biology ◽  
The Future ◽  
Mammary Stem

Translating Mammary Stem Cell and Cancer Stem Cell Biology to the Clinics

2011 ◽  
pp. 433-450
Author(s):  
Rajneesh Pathania ◽  
Vadivel Ganapathy ◽  
Muthusamy Thangaraju
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Biology ◽  
Mammary Stem Cell ◽  
Stem Cell Biology ◽  
Mammary Stem

CD24 and CD49f expressions of E14.5 mouse mammary anlagen cells define putative distribution of earlier embryonic mammary stem cell activities

2018 ◽  
Vol 96 (5) ◽  
pp. 539-547 ◽  
Author(s):  
Jiazhe Song ◽  
Fangrong Ding ◽  
Song Li ◽  
Wenzhe Li ◽  
Ning Li ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mammary Gland ◽  
Cell Population ◽  
Cell Biology ◽  
Cell Activity ◽  
Mammary Stem Cell ◽  
Flow Cytometry Analysis ◽  
Large Numbers ◽  
Stem Cell Activity ◽  
Mammary Stem

Stem cell biology offers promise for understanding the origins of the mammary gland. However, the distribution of mammary stem cell (MaSC) activities at earlier embryonic stages has not been fully identified. The markers for sorting adult MaSC, CD24, CD29, and CD49f have been applied to analyze fetal MaSCs. Here we explored mammary anlagen MaSCs by investigating the expression of CD24 and CD49f. According to the comparative analysis between adult mammary gland and fetal mammary anlagen, we found that fetal mouse mammary anlagen may possess a high percentage of potential MaSCs. Flow cytometry analysis revealed 2 distinct mammary anlagen populations: Lin–CD24med and Lin–CD24high. Sphere-forming and mammary repopulating assays confirmed that the stem cell activity of E14.5 mouse mammary anlagen was restricted to the Lin–CD24med cell population. Furthermore, CD24med mammary anlagen cells were separated into Lin–CD24medCD49f+ and Lin–CD24medCD49f– populations and identified, respectively. The results proved that the mammary anlagen Lin–CD24medCD49f+ cell population possesses more stem cell activities than the Lin–CD24medCD49f– cell population. However, a limited numbers of stem cells and large numbers of stromal cells were identified in mammary anlagen in the Lin–CD24med cell population.

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