Effects of oleic acid-induced lung injury on oxygen transport and aerobic capacity

2014 ◽  
Vol 196 ◽  
pp. 43-49 ◽  
Author(s):  
George H. Crocker ◽  
James H. Jones
Keyword(s):  
Oleic Acid ◽  
Lung Injury ◽  
Aerobic Capacity ◽  
Oxygen Transport

Effects of Vaporized Perfluorocarbon on Pulmonary Blood Flow and Ventilation/Perfusion Distribution in a Model of Acute Respiratory Distress Syndrome

2001 ◽  
Vol 95 (6) ◽  
pp. 1414-1421 ◽  
Author(s):  
Matthias Hübler ◽  
Jennifer E. Souders ◽  
Erin D. Shade ◽  
Nayak L. Polissar ◽  
Carmel Schimmel ◽  
...  
Keyword(s):  
Blood Flow ◽  
Oleic Acid ◽  
Gas Exchange ◽  
Lung Injury ◽  
Repeated Measures ◽  
Pulmonary Blood Flow ◽  
Analysis Of Covariance ◽  
Inert Gas ◽  
Low Flow ◽  
Repeated Measures Analysis

Background Perfluorocarbon (PFC) liquids are known to improve gas exchange and pulmonary function in various models of acute respiratory failure. Vaporization has been recently reported as a new method of delivering PFC to the lung. Our aim was to study the effect of PFC vapor on the ventilation/perfusion (VA/Q) matching and relative pulmonary blood flow (Qrel) distribution. Methods In nine sheep, lung injury was induced using oleic acid. Four sheep were treated with vaporized perfluorohexane (PFX) for 30 min, whereas the remaining sheep served as control animals. Vaporization was achieved using a modified isoflurane vaporizer. The animals were studied for 90 min after vaporization. VA/Q distributions were estimated using the multiple inert gas elimination technique. Change in Qrel distribution was assessed using fluorescent-labeled microspheres. Results Treatment with PFX vapor improved oxygenation significantly and led to significantly lower shunt values (P < 0.05, repeated-measures analysis of covariance). Analysis of the multiple inert gas elimination technique data showed that animals treated with PFX vapor demonstrated a higher VA/Q heterogeneity than the control animals (P < 0.05, repeated-measures analysis of covariance). Microsphere data showed a redistribution of Qrel attributable to oleic acid injury. Qrel shifted from areas that were initially high-flow to areas that were initially low-flow, with no difference in redistribution between the groups. After established injury, Qrel was redistributed to the nondependent lung areas in control animals, whereas Qrel distribution did not change in treatment animals. Conclusion In oleic acid lung injury, treatment with PFX vapor improves gas exchange by increasing VA/Q heterogeneity in the whole lung without a significant change in gravitational gradient.

scholarly journals Intratracheal Pulmonary Ventilation vs. Conventional Ventilation in an Oleic Acid Lung Injury Model in the Young Lamb 197

1998 ◽  
Vol 43 ◽  
pp. 36-36
Author(s):  
Allyson M Goodman ◽  
L Kyle Walker ◽  
Oswaldo Rivera ◽  
Winslow R Seale ◽  
Billie L Short
Keyword(s):  
Oleic Acid ◽  
Lung Injury ◽  
Pulmonary Ventilation ◽  
Conventional Ventilation ◽  
Injury Model ◽  
Lung Injury Model

Effects of Inverse Ratio Ventilation and Positive End-Expiratory Pressure in Oleic Acid–Induced Lung Injury

2000 ◽  
Vol 161 (5) ◽  
pp. 1537-1545 ◽  
Author(s):  
PETER NEUMANN ◽  
JAN E. BERGLUND ◽  
LARS G. ANDERSSON ◽  
ENN MARIPU ◽  
ANDERS MAGNUSSON ◽  
...  
Keyword(s):  
Oleic Acid ◽  
Lung Injury ◽  
Positive End Expiratory Pressure ◽  
Inverse Ratio Ventilation

scholarly journals TIP peptide inhalation in oleic acid-induced experimental lung injury: a post-hoc comparison

2013 ◽  
Vol 6 (1) ◽  
Author(s):  
Erik K Hartmann ◽  
Alexander Bentley ◽  
Bastian Duenges ◽  
Klaus U Klein ◽  
Stefan Boehme ◽  
...  
Keyword(s):  
Oleic Acid ◽  
Lung Injury ◽  
Post Hoc

scholarly journals Effect of Recruitment and Body Positioning on Lung Volume and Oxygenation in Acute Lung Injury Model

2008 ◽  
Vol 36 (6) ◽  
pp. 792-797 ◽  
Author(s):  
H. G. Ryu ◽  
J.-H. Bahk ◽  
H.-J. Lee ◽  
J.-G. Im
Keyword(s):  
Acute Lung Injury ◽  
Oleic Acid ◽  
Lung Injury ◽  
Lung Volume ◽  
Supine Position ◽  
Recruitment Manoeuvre ◽  
Prone Positioning ◽  
Dependent Lung ◽  
Arterial Blood Gas ◽  
Arterial Blood

The mechanism of oxygenation improvement after recruitment manoeuvres or prone positioning in acute lung injury or acute respiratory distress syndrome is still unclear. We tried to determine the mechanism responsible for the effects of recruitment manoeuvres or prone positioning on lung aeration using a whole lung computed tomography scan in an oleic acid induced acute lung injury canine model. Twelve adult mongrel dogs were allocated into either the supine group (n=6) or the prone group (n = 6). After the establishment of acute lung injury, three recruitment manoeuvres were performed at one-hour intervals. Haemodynamic and ventilatory variables, arterial blood gas analyses and CT scans of the whole lung were obtained 90 minutes after oleic acid injection and five minutes before and after each recruitment manoeuvre. Recruitment manoeuvres in the supine position improved oxygenation (P=0.025) that correlated with increase of the poorly- and well-aerated dorsal (dependent) lung volume (r=0.436, P=0.016). Prone positioning increased oxygenation (P=0.004) that also correlated with increase of the poorly- and well-aerated dorsal (nondependent) lung volume (r=0.787, P <0.001). However, the recruitment manoeuvre in the prone position had no effect on oxygenation despite an increase in ventral (dependent) lung volume. The increase in PO2 after recruitment manoeuvres in the supine position or after prone positioning is related to the increase of the poorly- and well-aerated dorsal lung.

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