Role of the PLA2-Activated Neutrophilic Oxidative Stress in Oleic Acid-Induced Acute Lung Injury

2010 ◽  
Vol 68 (2) ◽  
pp. 55 ◽  
Author(s):  
Young Man Lee ◽  
Byung Yong Kim ◽  
Yoon Yub Park
Keyword(s):  
Oxidative Stress ◽  
Acute Lung Injury ◽  
Oleic Acid ◽  
Lung Injury

scholarly journals Endogeous sulfur dioxide protects against oleic acid-induced acute lung injury in association with inhibition of oxidative stress in rats

2015 ◽  
Vol 95 (2) ◽  
pp. 142-156 ◽  
Author(s):  
Siyao Chen ◽  
Saijun Zheng ◽  
Zhiwei Liu ◽  
Chaoshu Tang ◽  
Bin Zhao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Acute Lung Injury ◽  
Oleic Acid ◽  
Sulfur Dioxide ◽  
Lung Injury

scholarly journals Oxidative stress-induced FABP5 S-glutathionylation protects against acute lung injury by suppressing inflammation in macrophages

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yuxian Guo ◽  
Yaru Liu ◽  
Shihao Zhao ◽  
Wangting Xu ◽  
Yiqing Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Target Genes ◽  
Nuclear Translocation ◽  
Protein S ◽  
Protective Role ◽  
Fatty Acid Binding ◽  
Proteomics Approach

AbstractOxidative stress contributes to the pathogenesis of acute lung injury. Protein S-glutathionylation plays an important role in cellular antioxidant defense. Here we report that the expression of deglutathionylation enzyme Grx1 is decreased in the lungs of acute lung injury mice. The acute lung injury induced by hyperoxia or LPS is significantly relieved in Grx1 KO and Grx1fl/flLysMcre mice, confirming the protective role of Grx1-regulated S-glutathionylation in macrophages. Using a quantitative redox proteomics approach, we show that FABP5 is susceptible to S-glutathionylation under oxidative conditions. S-glutathionylation of Cys127 in FABP5 promotes its fatty acid binding ability and nuclear translocation. Further results indicate S-glutathionylation promotes the interaction of FABP5 and PPARβ/δ, activates PPARβ/δ target genes and suppresses the LPS-induced inflammation in macrophages. Our study reveals a molecular mechanism through which FABP5 S-glutathionylation regulates macrophage inflammation in the pathogenesis of acute lung injury.

scholarly journals Oxidative Stress in Early Stage of Acute Lung Injury Induced with Oleic Acid in Guinea Pigs

2003 ◽  
Vol 26 (4) ◽  
pp. 424-428 ◽  
Author(s):  
Changqing Yang ◽  
Hiroshi Moriuchi ◽  
Junko Takase ◽  
Yoichi Ishitsuka ◽  
Mitsuru Irikura ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Acute Lung Injury ◽  
Oleic Acid ◽  
Lung Injury ◽  
Guinea Pigs ◽  
Early Stage

Role of Cyclooxygenase-2 in Oleic Acid–Induced Acute Lung Injury

1999 ◽  
Vol 160 (4) ◽  
pp. 1165-1170 ◽  
Author(s):  
RENÉ GUST ◽  
JAMES K. KOZLOWSKI ◽  
ALAN H. STEPHENSON ◽  
DANIEL P. SCHUSTER
Keyword(s):  
Acute Lung Injury ◽  
Oleic Acid ◽  
Lung Injury ◽  
Cyclooxygenase 2

Crucial Role of Group IIA Phospholipase A2in Oleic Acid–Induced Acute Lung Injury in Rabbits

1999 ◽  
Vol 160 (4) ◽  
pp. 1292-1302 ◽  
Author(s):  
SHINGO FURUE ◽  
KENJI KUWABARA ◽  
KATSUYA MIKAWA ◽  
KAHORU NISHINA ◽  
MAKOTO SHIGA ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Oleic Acid ◽  
Lung Injury ◽  
Crucial Role
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