Interactive effects of hypoxia, carbon monoxide and acute lung injury on oxygen transport and aerobic capacity

2016 ◽  
Vol 225 ◽  
pp. 31-37 ◽  
Author(s):  
George H. Crocker ◽  
James H. Jones
Keyword(s):  
Carbon Monoxide ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Aerobic Capacity ◽  
Oxygen Transport ◽  
Interactive Effects

scholarly journals Exhaled carbon monoxide and inducible heme oxygenase expression in a rat model of postperfusion acute lung injury

2003 ◽  
Vol 126 (6) ◽  
pp. 1867-1874 ◽  
Author(s):  
Rachid Zegdi ◽  
Olivier Fabre ◽  
Nermine Lila ◽  
Paul Fornès ◽  
Michèle Cambillau ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Heme Oxygenase ◽  
Rat Model ◽  
Exhaled Carbon Monoxide

Phototherapy and extracorporeal membrane oxygenation facilitate removal of carbon monoxide in rats

2019 ◽  
Vol 11 (513) ◽  
pp. eaau4217
Author(s):  
Luca Zazzeron ◽  
Anna Fischbach ◽  
Walfre Franco ◽  
William A. Farinelli ◽  
Fumito Ichinose ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Visible Light ◽  
Smoke Inhalation ◽  
Co Poisoning ◽  
Membrane Oxygenator ◽  
Injury Treatment ◽  
Further Development

Inhaled carbon monoxide (CO) displaces oxygen from hemoglobin, reducing the capacity of blood to carry oxygen. Current treatments for CO-poisoned patients involve administration of 100% oxygen; however, when CO poisoning is associated with acute lung injury secondary to smoke inhalation, burns, or trauma, breathing 100% oxygen may be ineffective. Visible light dissociates CO from hemoglobin. We hypothesized that the exposure of blood to visible light while passing through a membrane oxygenator would increase the rate of CO elimination in vivo. We developed a membrane oxygenator with optimal characteristics to facilitate exposure of blood to visible light and tested the device in a rat model of CO poisoning, with or without concomitant lung injury. Compared to ventilation with 100% oxygen, the addition of extracorporeal removal of CO with phototherapy (ECCOR-P) doubled the rate of CO elimination in CO-poisoned rats with normal lungs. In CO-poisoned rats with acute lung injury, treatment with ECCOR-P increased the rate of CO removal by threefold compared to ventilation with 100% oxygen alone and was associated with improved survival. Further development and adaptation of this extracorporeal CO photo-removal device for clinical use may provide additional benefits for CO-poisoned patients, especially for those with concurrent acute lung injury.

scholarly journals Cell-cell interactions and bronchoconstrictor eicosanoid reduction with inhaled carbon monoxide and resolvin D1

2014 ◽  
Vol 307 (10) ◽  
pp. L746-L757 ◽  
Author(s):  
Masakazu Shinohara ◽  
Megumi Kibi ◽  
Ian R. Riley ◽  
Nan Chiang ◽  
Jesmond Dalli ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Whole Blood ◽  
Low Dose ◽  
Ischemia Reperfusion ◽  
Resolvin D1 ◽  
Human Whole Blood ◽  
Lung Protection ◽  
Platelet Aggregates

Polymorphonuclear leukocyte (PMN)-mediated acute lung injury from ischemia/reperfusion (I/R) remains a major cause of morbidity and mortality in critical care medicine. Here, we report that inhaled low-dose carbon monoxide (CO) and intravenous resolvin D1 (RvD1) in mice each reduced PMN-mediated acute lung injury from I/R. Inhaled CO (125–250 ppm) and RvD1 (250–500 ng) each reduced PMN lung infiltration and gave additive lung protection. In mouse whole blood, CO and RvD1 attenuated PMN-platelet aggregates, reducing leukotrienes (LTs) and thromboxane B2(TxB2) in I/R lungs. With human whole blood, CO (125–250 ppm) decreased PMN-platelet aggregates, expression of adhesion molecules, and cysteinyl LTs, as well as TxB2. RvD1 (1–100 nM) also dose dependently reduced platelet activating factor-stimulated PMN-platelet aggregates in human whole blood. In nonhuman primate (baboon) lung infection with Streptococcus pneumoniae, inhaled CO reduced urinary cysteinyl LTs. These results demonstrate lung protection by low-dose inhaled CO as well as RvD1 that each reduced PMN-mediated acute tissue injury, PMN-platelet interactions, and production of both cysteinyl LTs and TxB2. Together they suggest a potential therapeutic role of low-dose inhaled CO in organ protection, as demonstrated using mouse I/R-initiated lung injury, baboon infections, and human whole blood.

Interactive effects of mechanical ventilation, inhaled nitric oxide and oxidative stress in acute lung injury

2014 ◽  
Vol 190 ◽  
pp. 118-123 ◽  
Author(s):  
Carlos Fernando Ronchi ◽  
Ana Lucia Anjos Ferreira ◽  
Fabio Joly Campos ◽  
Cilmery Suemi Kurokawa ◽  
Mario Ferreira Carpi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Mechanical Ventilation ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Inhaled Nitric Oxide ◽  
Interactive Effects ◽  
And Oxidative Stress

Carbon Monoxide in Acute Lung Injury

2012 ◽  
Vol 13 (6) ◽  
pp. 777-786 ◽  
Author(s):  
Simone Faller ◽  
Alexander Hoetzel
Keyword(s):  
Carbon Monoxide ◽  
Acute Lung Injury ◽  
Lung Injury

Carbon monoxide can prevent acute lung injury observed after ischemia reperfusion of the lower extremities

2005 ◽  
Vol 201 (3) ◽  
pp. S102
Author(s):  
Cherif N. Boutros ◽  
Rachid Zegdi ◽  
Nermine Lila ◽  
Michele Combillau ◽  
Paul Fornes ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Ischemia Reperfusion ◽  
Lower Extremities

Tristetraprolin Mediates Anti-Inflammatory Effects of Carbon Monoxide on Lipopolysaccharide-Induced Acute Lung Injury

2015 ◽  
Vol 185 (11) ◽  
pp. 2867-2874 ◽  
Author(s):  
Yeonsoo Joe ◽  
Seul-Ki Kim ◽  
Yingqing Chen ◽  
Jung Wook Yang ◽  
Jeong-Hee Lee ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Anti Inflammatory

Carbon Monoxide-Releasing Molecule-3 Ameliorates Acute Lung Injury in a Model of Hemorrhagic Shock and Resuscitation

Shock ◽  
2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Jing Bai ◽  
Yang Bai ◽  
Xu-Peng Wang ◽  
Wei-Chao Zheng ◽  
Li-Min Zhang
Keyword(s):  
Carbon Monoxide ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Hemorrhagic Shock
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