Hyalinizing clear cell carcinoma of salivary glands: A retrospective study focused on uncommon morphology, immunohistochemistry, and detection of gene fusion using fluorescence in situ hybridization

2018 ◽  
Vol 214 (3) ◽  
pp. 380-384 ◽  
Author(s):  
Yi-nuo Zhao ◽  
Xiao Wang ◽  
Fen-hua Liang ◽  
Wen-jie Zhang ◽  
Xiang-tao Song
Keyword(s):  
In Situ Hybridization ◽  
Retrospective Study ◽  
Fluorescence In Situ Hybridization ◽  
Cell Carcinoma ◽  
Salivary Glands ◽  
Gene Fusion ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Hyalinizing Clear Cell Carcinoma

Nasopharyngeal hyalinizing clear cell carcinoma with EWSR1 rearrangements diagnosed by fluorescence in situ hybridization

2015 ◽  
Vol 42 (5) ◽  
pp. 412-415 ◽  
Author(s):  
Atsushi Fukuda ◽  
Yohei Tagami ◽  
Akira Takasawa ◽  
Shintaro Sugita ◽  
Rinnosuke Kuramoto ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Hyalinizing Clear Cell Carcinoma

scholarly journals A Case of Hyalinizing Clear Cell Carcinoma, So-Called Clear Cell Carcinoma, Not Otherwise Specified, of the Minor Salivary Glands of the Buccal Mucosa

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Takahiro Yamanishi ◽  
Kiwako Kutsuma ◽  
Keisuke Masuyama
Keyword(s):  
Cell Carcinoma ◽  
Salivary Glands ◽  
Tumor Cells ◽  
Buccal Mucosa ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Minor Salivary Glands ◽  
Hyalinizing Clear Cell Carcinoma ◽  
Not Otherwise Specified ◽  
The Right

Hyalinizing clear cell carcinoma (HCCC), so-called clear cell carcinoma, not otherwise specified (CCC (NOS)), of the salivary glands is a rare and low-grade malignant tumor. We report a case of HCCC so-called CCC (NOS) (referred to as HCCC) of the minor salivary gland of the buccal mucosa. A 52-year-old woman had presented with a gradually growing and indolent mass in the right buccal mucosa for about two years. The first biopsy histopathologically suggested the possibility of malignancy derived from the minor salivary glands. A month later, she visited our hospital. The tumor measured approximately 1.5 cm in diameter and was elastic hard, smooth, and well movable. Image examinations demonstrated internal homogeneity of the lesion, which had a smooth margin, in the right buccal mucosa. Complete tumor resection followed by covering with a polyglycolic acid sheet and fibrin glue spray was performed without surgical flap reconstruction. Histopathological findings revealed proliferating tumor cells with clear cytoplasm surrounded by hyalinizing stroma in the submucosal minor salivary glands. Immunohistochemical stains revealed these tumor cells to be positive for epithelial cell markers but negative for myoepithelial ones. These findings confirmed the diagnosis of HCCC. Good wound healing and no evidence of local recurrence and metastasis have been shown since surgery.

scholarly journals Hyalinizing clear cell carcinoma of parotid, intricacies of management:a rare case report

2021 ◽  
pp. 171-175
Keyword(s):  
Cell Carcinoma ◽  
Salivary Glands ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Hyalinizing Clear Cell Carcinoma ◽  
Insidious Onset ◽  
Rare Case Report ◽  
Needle Aspiration Cytology

Hyalinizing clear cell carcinoma (HCCC) usually affects minor salivary glands. It rarely occurs in major salivary glands. HCCCis difficult to diagnose in Fine Needle Aspiration cytology (FNAC). The possibility of metastasis from other primary sites should be rejected during the management of these tumors. An elderly manpresented with insidious onset, and gradual progressive painless swelling arising from the deep lobe of the parotid gland. FNAC, which was performedtwice with UltrasoundGuidance(USG), could not provide much detail about the type of tumor. Total conservative parotidectomy was conducted. These rare tumors cause significant challenges to physicians. Thehigh index of suspicion and combined efforts ofthe multidisciplinary team are pivotal in management.

Hyalinizing clear cell carcinoma of the base of the tongue

2002 ◽  
Vol 116 (10) ◽  
pp. 851-853 ◽  
Author(s):  
R. Balakrishnan ◽  
Dipak Ranjan Nayak ◽  
Suresh Pillai ◽  
Lakshmi Rao
Keyword(s):  
Oral Cavity ◽  
Cell Carcinoma ◽  
Salivary Glands ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Minor Salivary Glands ◽  
Rare Tumour ◽  
Hyalinizing Clear Cell Carcinoma ◽  
Epithelial Myoepithelial Carcinoma ◽  
Base Of The Tongue

Clear cell carcinoma of the salivary glands is a rare tumour that represents less than one per cent of all salivary tumours. They are divided into a biphasic, epithelial-myoepithelial carcinoma and a monophasic pattern which may be myoepithelial or ductal in origin. The latter is accompanied by prominent fibrohyaline stroma and has been described recently as hyalinizing clear cell carcinoma (HCCC).Most of the HCCC occur in the oral cavity, and are associated with minor salivary glands, unlike the biphasic pattern which is more common in the major salivary glands. In the oral cavity, the commonest site is the palate followed by the lips and the buccal mucosa. Its occurrence in the oropharynx and the larynx is extremely rare.

Hyalinizing clear-cell carcinoma of salivary glands in fine-needle aspiration

2000 ◽  
Vol 23 (5) ◽  
pp. 333-337 ◽  
Author(s):  
Sara Milchgrub ◽  
Frank Vuitch ◽  
M. Hossein Saboorian ◽  
Arif Hameed ◽  
Horace Wu ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Salivary Glands ◽  
Fine Needle Aspiration ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Needle Aspiration ◽  
Fine Needle ◽  
Hyalinizing Clear Cell Carcinoma

scholarly journals Hyalinizing clear cell carcinoma in minor salivary glands of maxillary tuberosity

2005 ◽  
Vol 41 (10) ◽  
pp. 306-310 ◽  
Author(s):  
Zhi-Jun Sun ◽  
Yi-Fang Zhao ◽  
Lu Zhang ◽  
Wen-Feng Zhang ◽  
Xin-Ming Chen ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Salivary Glands ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Minor Salivary Glands ◽  
Hyalinizing Clear Cell Carcinoma ◽  
Maxillary Tuberosity

Hyalinizing clear cell carcinoma of salivary glands: a study of extracellular matrix

Oral Oncology ◽  
2002 ◽  
Vol 38 (4) ◽  
pp. 364-368 ◽  
Author(s):  
Ana Félix ◽  
Joaninha Costa Rosa ◽  
José F Moura Nunes ◽  
Isabel Fonseca ◽  
António Cidadão ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cell Carcinoma ◽  
Salivary Glands ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Hyalinizing Clear Cell Carcinoma
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