scholarly journals A Case of Hyalinizing Clear Cell Carcinoma, So-Called Clear Cell Carcinoma, Not Otherwise Specified, of the Minor Salivary Glands of the Buccal Mucosa

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Takahiro Yamanishi ◽  
Kiwako Kutsuma ◽  
Keisuke Masuyama
Keyword(s):  
Cell Carcinoma ◽  
Salivary Glands ◽  
Tumor Cells ◽  
Buccal Mucosa ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Minor Salivary Glands ◽  
Hyalinizing Clear Cell Carcinoma ◽  
Not Otherwise Specified ◽  
The Right

Hyalinizing clear cell carcinoma (HCCC), so-called clear cell carcinoma, not otherwise specified (CCC (NOS)), of the salivary glands is a rare and low-grade malignant tumor. We report a case of HCCC so-called CCC (NOS) (referred to as HCCC) of the minor salivary gland of the buccal mucosa. A 52-year-old woman had presented with a gradually growing and indolent mass in the right buccal mucosa for about two years. The first biopsy histopathologically suggested the possibility of malignancy derived from the minor salivary glands. A month later, she visited our hospital. The tumor measured approximately 1.5 cm in diameter and was elastic hard, smooth, and well movable. Image examinations demonstrated internal homogeneity of the lesion, which had a smooth margin, in the right buccal mucosa. Complete tumor resection followed by covering with a polyglycolic acid sheet and fibrin glue spray was performed without surgical flap reconstruction. Histopathological findings revealed proliferating tumor cells with clear cytoplasm surrounded by hyalinizing stroma in the submucosal minor salivary glands. Immunohistochemical stains revealed these tumor cells to be positive for epithelial cell markers but negative for myoepithelial ones. These findings confirmed the diagnosis of HCCC. Good wound healing and no evidence of local recurrence and metastasis have been shown since surgery.

Hyalinizing clear cell carcinoma of the base of the tongue

2002 ◽  
Vol 116 (10) ◽  
pp. 851-853 ◽  
Author(s):  
R. Balakrishnan ◽  
Dipak Ranjan Nayak ◽  
Suresh Pillai ◽  
Lakshmi Rao
Keyword(s):  
Oral Cavity ◽  
Cell Carcinoma ◽  
Salivary Glands ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Minor Salivary Glands ◽  
Rare Tumour ◽  
Hyalinizing Clear Cell Carcinoma ◽  
Epithelial Myoepithelial Carcinoma ◽  
Base Of The Tongue

Clear cell carcinoma of the salivary glands is a rare tumour that represents less than one per cent of all salivary tumours. They are divided into a biphasic, epithelial-myoepithelial carcinoma and a monophasic pattern which may be myoepithelial or ductal in origin. The latter is accompanied by prominent fibrohyaline stroma and has been described recently as hyalinizing clear cell carcinoma (HCCC).Most of the HCCC occur in the oral cavity, and are associated with minor salivary glands, unlike the biphasic pattern which is more common in the major salivary glands. In the oral cavity, the commonest site is the palate followed by the lips and the buccal mucosa. Its occurrence in the oropharynx and the larynx is extremely rare.

scholarly journals Hyalinizing clear cell carcinoma in minor salivary glands of maxillary tuberosity

2005 ◽  
Vol 41 (10) ◽  
pp. 306-310 ◽  
Author(s):  
Zhi-Jun Sun ◽  
Yi-Fang Zhao ◽  
Lu Zhang ◽  
Wen-Feng Zhang ◽  
Xin-Ming Chen ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Salivary Glands ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Minor Salivary Glands ◽  
Hyalinizing Clear Cell Carcinoma ◽  
Maxillary Tuberosity

scholarly journals A case of clear cell carcinoma, not otherwise specified （NOS） of the buccal mucosa

2012 ◽  
Vol 58 (5) ◽  
pp. 288-291 ◽  
Author(s):  
Megumi ONODA ◽  
Katsuhiro SEKI ◽  
Tatsuya IKARI ◽  
Wataru KUMAMARU ◽  
Tsuyoshi SUGIURA ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Buccal Mucosa ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Not Otherwise Specified

scholarly journals Hyalinizing clear cell carcinoma of parotid, intricacies of management:a rare case report

2021 ◽  
pp. 171-175
Keyword(s):  
Cell Carcinoma ◽  
Salivary Glands ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Hyalinizing Clear Cell Carcinoma ◽  
Insidious Onset ◽  
Rare Case Report ◽  
Needle Aspiration Cytology

Hyalinizing clear cell carcinoma (HCCC) usually affects minor salivary glands. It rarely occurs in major salivary glands. HCCCis difficult to diagnose in Fine Needle Aspiration cytology (FNAC). The possibility of metastasis from other primary sites should be rejected during the management of these tumors. An elderly manpresented with insidious onset, and gradual progressive painless swelling arising from the deep lobe of the parotid gland. FNAC, which was performedtwice with UltrasoundGuidance(USG), could not provide much detail about the type of tumor. Total conservative parotidectomy was conducted. These rare tumors cause significant challenges to physicians. Thehigh index of suspicion and combined efforts ofthe multidisciplinary team are pivotal in management.

scholarly journals A Case of Buccal Clear Cell Carcinoma Caused by Rare Fusion Gene: EWSR1-CREM

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Miyako Hoshino ◽  
Katsuyuki Inoue ◽  
Tomohisa Kaneda ◽  
Michiko Nishimura ◽  
Kaoru Kusama ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Buccal Mucosa ◽  
Clear Cell ◽  
Fusion Gene ◽  
Clear Cell Carcinoma ◽  
Histopathological Examination ◽  
Salivary Gland Tumor ◽  
Clear Cells ◽  
Painless Mass ◽  
The Right

Clear cell carcinoma (CCC) is a rare entity in the salivary gland tumor. So far, only 10 cases of primary CCC of the buccal mucosa have been reported. Here, we first report an extremely rare case of buccal CCC with the EWSR1-CREM fusion gene. The patient, a 69-year-old woman, presented with a painless mass in the right buccal mucosa. The tumor, which had been present for about 10 years, measured approximately 15 mm in diameter and was pedunculated, elastic hard, smooth, and mobile. Histopathological examination revealed proliferating tumor cells with vacuolated and clear cytoplasm partially surrounded by hyalinized stroma. The tumor was not encapsulated, and no contact with the overlying epithelium was evident. Duct-like structures were occasionally observed in the tumor nests composed of clear cells. The tumor had invaded into surrounding muscle and adipose tissues. Immunohistochemical examination revealed that the clear cells were positive for epithelial cell markers, and myoepithelial markers were negative. Fluorescence in situ hybridization (FISH), performed to search for genetic abnormalities, demonstrated split positivity for EWSR1, and fusion with CREM was confirmed. These findings suggested a diagnosis of CCC.

Hyalinising clear cell carcinoma of salivary gland: a case report

2020 ◽  
Vol 18 (2) ◽  
pp. 127-130
Author(s):  
Michał Osuchowski ◽  
◽  
Dorota Bartusik-Aebisher ◽  
Ewa Kaznowska ◽  
David Aebisher ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Lymph Node ◽  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Distant Metastases ◽  
Minor Salivary Glands ◽  
Not Otherwise Specified ◽  
Eosinophilic Cytoplasm ◽  
History Of

Introduction. Clear cell carcinoma, not otherwise specified/hyalinising clear cell carcinoma of the salivary gland (HCCC) is a malignancy that arises in minor salivary glands. It rarely leads to distant metastases or cancer-related death but has the potential for recurrence and focal metastases. Aim. A case is reported. Description of the case. A 72 years old female patient has reported to the Clinic of Otolaryngology with a tongue lesion. The patient had no history of malignancy. The lymph node has been surgically removed for further examination. Cords and nests of clear cells and cells with eosinophilic cytoplasm in a hyalinized stroma were identified within the lymph node. After the diagnosis the patient has been transferred to another Oncology Hospital for further treatment. Conclusion. The diagnosis of clear cell carcinoma may be challenging because many of it‘s features frequently overlap with other salivary gland lesions.

Clear cell carcinoma of minor salivary glands

1990 ◽  
Vol 17 (5) ◽  
pp. 433-438 ◽  
Author(s):  
R.H.W. SIMPSON ◽  
P.T.L. SARSFIELD ◽  
T. CLARKE ◽  
A.V. BABAJEWS
Keyword(s):  
Cell Carcinoma ◽  
Salivary Glands ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Minor Salivary Glands

Hyalinizing clear-cell carcinoma of salivary glands in fine-needle aspiration

2000 ◽  
Vol 23 (5) ◽  
pp. 333-337 ◽  
Author(s):  
Sara Milchgrub ◽  
Frank Vuitch ◽  
M. Hossein Saboorian ◽  
Arif Hameed ◽  
Horace Wu ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Salivary Glands ◽  
Fine Needle Aspiration ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Needle Aspiration ◽  
Fine Needle ◽  
Hyalinizing Clear Cell Carcinoma

scholarly journals Clear cell carcinoma of the minor salivary glands. Report of a case

1997 ◽  
Vol 42 (1) ◽  
pp. 8-10 ◽  
Author(s):  
E. Triantafillidou ◽  
I. Dimitrakopoulos ◽  
A. Skordalaki
Keyword(s):  
Cell Carcinoma ◽  
Salivary Glands ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Minor Salivary Glands
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