A preliminary study on fetal lung injury in a rat model of acute pancreatitis in pregnancy

2017 ◽  
Vol 213 (11) ◽  
pp. 1370-1377 ◽  
Author(s):  
Liang Zhao ◽  
Teng Zuo ◽  
Qiao Shi ◽  
Fang-chao Mei ◽  
Yu-pu Hong ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Lung Injury ◽  
Rat Model ◽  
Fetal Lung ◽  
Preliminary Study ◽  
In Pregnancy

scholarly journals Naringin Attenuated Acute Lung Injury in Rat Model with Acute Pancreatitis in Pregnancy through Inactivation of p38 MAPK Pathway

2020 ◽  
Keyword(s):  
Acute Pancreatitis ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Mapk Pathway ◽  
Sodium Taurocholate ◽  
Fetal Lung ◽  
Pathological Changes ◽  
Tnf Α ◽  
Necrosis Factor ◽  
In Pregnancy

Acute pancreatitis in pregnancy can cause fetal lung injury. Naringin exhibits ant-inflammation effect against pulmonary injuries. However, whether naringin can alleviate lung injury associated with acute pancreatitis in pregnancy has not been elucidated. Establishment of acute pancreatitis in pregnancy model by sodium taurocholate showed that sodium taurocholate induced obvious pathological changes in pancreas. Histopathological changes in lungs were also aggravated post sodium taurocholate treatment with enhanced inflammation of neutrophils, thickened alveolar walls and alveolus collapse. Diagnostic blood tests for acute pancreatitis in pregnancy indicated that serum amylase and lipase were increased post sodium taurocholate treatment. Sodium taurocholate-induced rats were intragastrically administered with naringin to investigate the protective effect of naringin on acute lung injury induced by acute pancreatitis in pregnancy. Results revealed that administration of naringin could attenuate pathological changes in pancreas and lungs and decrease amylase and lipase. Moreover, naringin treatment attenuated sodium taurocholate-induced increase in inflammatory cytokines, including tumor necrosis factor (TNF)-α, interleukin (IL)-6/1β in lungs. Sodium taurocholate-induced increase in phosphorylation of p38 was also reduced post naringin treatment. In conclusion, naringin could ameliorate acute lung injury and inflammation induced by acute pancreatitis in pregnancy by inhibiting the p38 pathway.

Mitogen-Activated Protein Kinases Are Activated in Placental Injury in Rat Model of Acute Pancreatitis in Pregnancy

Pancreas ◽  
2016 ◽  
Vol 45 (6) ◽  
pp. 850-857 ◽  
Author(s):  
Teng Zuo ◽  
Jia Yu ◽  
Wei-xing Wang ◽  
Kai-liang Zhao ◽  
Chen Chen ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Protein Kinases ◽  
Rat Model ◽  
Mitogen Activated Protein Kinases ◽  
Mitogen Activated Protein ◽  
In Pregnancy

scholarly journals Development of a rat model of severe acute pancreatitis-associated lung injury

2013 ◽  
Vol 21 (3) ◽  
pp. 211 ◽  
Author(s):  
Hao Wang ◽  
Jiang-Wei Liu ◽  
Zhi-Ling Li ◽  
Xiao-Yu Xue ◽  
Hong-Yan Zhao ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Lung Injury ◽  
Severe Acute Pancreatitis ◽  
Rat Model

Differential JNK, p38 and ERK response to renal injury in a rat model of acute pancreatitis in pregnancy

2018 ◽  
Vol 297 (4) ◽  
pp. 933-942 ◽  
Author(s):  
Fangchao Mei ◽  
Teng Zuo ◽  
Liang Zhao ◽  
Qiao Shi ◽  
Mingwei Xiang ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Rat Model ◽  
Renal Injury ◽  
In Pregnancy

Evaluation of lung injury and respiratory mechanics in a rat model of acute pancreatitis complicated with endotoxin

Pancreatology ◽  
2012 ◽  
Vol 12 (3) ◽  
pp. 240-247 ◽  
Author(s):  
Alison S.F. Elder ◽  
Gino T.P. Saccone ◽  
Andrew D. Bersten ◽  
Dani-Louise Dixon
Keyword(s):  
Acute Pancreatitis ◽  
Lung Injury ◽  
Rat Model ◽  
Respiratory Mechanics
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