Evaluation of lung injury and respiratory mechanics in a rat model of acute pancreatitis complicated with endotoxin

Pancreatology ◽  
2012 ◽  
Vol 12 (3) ◽  
pp. 240-247 ◽  
Author(s):  
Alison S.F. Elder ◽  
Gino T.P. Saccone ◽  
Andrew D. Bersten ◽  
Dani-Louise Dixon
Keyword(s):  
Acute Pancreatitis ◽  
Lung Injury ◽  
Rat Model ◽  
Respiratory Mechanics

A preliminary study on fetal lung injury in a rat model of acute pancreatitis in pregnancy

2017 ◽  
Vol 213 (11) ◽  
pp. 1370-1377 ◽  
Author(s):  
Liang Zhao ◽  
Teng Zuo ◽  
Qiao Shi ◽  
Fang-chao Mei ◽  
Yu-pu Hong ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Lung Injury ◽  
Rat Model ◽  
Fetal Lung ◽  
Preliminary Study ◽  
In Pregnancy

scholarly journals Development of a rat model of severe acute pancreatitis-associated lung injury

2013 ◽  
Vol 21 (3) ◽  
pp. 211 ◽  
Author(s):  
Hao Wang ◽  
Jiang-Wei Liu ◽  
Zhi-Ling Li ◽  
Xiao-Yu Xue ◽  
Hong-Yan Zhao ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Lung Injury ◽  
Severe Acute Pancreatitis ◽  
Rat Model

Pretreatment of a matrix metalloproteases inhibitor and aprotinin attenuated the development of acute pancreatitis-induced lung injury in rat model

Immunobiology ◽  
2018 ◽  
Vol 223 (1) ◽  
pp. 64-72 ◽  
Author(s):  
Kuang-En Chu ◽  
Yao Fong ◽  
David Wang ◽  
Chao Fuh Chen ◽  
Diana Yu-Wung Yeh
Keyword(s):  
Acute Pancreatitis ◽  
Lung Injury ◽  
Rat Model ◽  
Matrix Metalloproteases

scholarly journals Effect of pressure-controlled ventilation-volume guaranteed mode combined with individualized positive end-expiratory pressure on respiratory mechanics, oxygenation and lung injury in patients undergoing laparoscopic surgery in Trendelenburg position

2021 ◽  
Author(s):  
Jianli Li ◽  
Saixian Ma ◽  
Xiujie Chang ◽  
Songxu Ju ◽  
Meng Zhang ◽  
...  
Keyword(s):  
Laparoscopic Surgery ◽  
Lung Injury ◽  
Respiratory Mechanics ◽  
Lung Mechanics ◽  
Trial Registry ◽  
Positive End Expiratory Pressure ◽  
Clinical Trial Registry ◽  
Trendelenburg Position ◽  
Pressure Controlled Ventilation ◽  
Pressure Controlled

AbstractThe study aimed to investigate the efficacy of PCV-VG combined with individual PEEP during laparoscopic surgery in the Trendelenburg position. 120 patients were randomly divided into four groups: VF group (VCV plus 5cmH2O PEEP), PF group (PCV-VG plus 5cmH2O PEEP), VI group (VCV plus individual PEEP), and PI group (PCV-VG plus individual PEEP). Pmean, Ppeak, Cdyn, PaO2/FiO2, VD/VT, A-aDO2 and Qs/Qt were recorded at T1 (15 min after the induction of anesthesia), T2 (60 min after pneumoperitoneum), and T3 (5 min at the end of anesthesia). The CC16 and IL-6 were measured at T1 and T3. Our results showed that the Pmean was increased in VI and PI group, and the Ppeak was lower in PI group at T2. At T2 and T3, the Cdyn of PI group was higher than that in other groups, and PaO2/FiO2 was increased in PI group compared with VF and VI group. At T2 and T3, A-aDO2 of PI and PF group was reduced than that in other groups. The Qs/Qt was decreased in PI group compared with VF and VI group at T2 and T3. At T2, VD/VT in PI group was decreased than other groups. At T3, the concentration of CC16 in PI group was lower compared with other groups, and IL-6 level of PI group was decreased than that in VF and VI group. In conclusion, the patients who underwent laparoscopic surgery, PCV-VG combined with individual PEEP produced favorable lung mechanics and oxygenation, and thus reducing inflammatory response and lung injury.Clinical Trial registry: chictr.org. identifier: ChiCTR-2100044928

Ulinastatin is a novel candidate drug for sepsis and secondary acute lung injury, evidence from an optimized CLP rat model

2013 ◽  
Vol 17 (3) ◽  
pp. 799-807 ◽  
Author(s):  
Ning Wang ◽  
Xin Liu ◽  
Xinchuan Zheng ◽  
Hongwei Cao ◽  
Guo Wei ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Rat Model ◽  
Candidate Drug
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