Fetal liver injury ameliorated by migration inhibitory factor inhibition in a rat model of acute pancreatitis in pregnancy

2017 ◽  
Vol 44 (3) ◽  
pp. 374-383 ◽  
Author(s):  
Zheng-Da Guo ◽  
Liang Zhao ◽  
Peng Wang ◽  
Wen-Hong Deng ◽  
Qiao Shi ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Liver Injury ◽  
Rat Model ◽  
Migration Inhibitory Factor ◽  
Fetal Liver ◽  
Inhibitory Factor ◽  
In Pregnancy

A preliminary study on fetal lung injury in a rat model of acute pancreatitis in pregnancy

2017 ◽  
Vol 213 (11) ◽  
pp. 1370-1377 ◽  
Author(s):  
Liang Zhao ◽  
Teng Zuo ◽  
Qiao Shi ◽  
Fang-chao Mei ◽  
Yu-pu Hong ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Lung Injury ◽  
Rat Model ◽  
Fetal Lung ◽  
Preliminary Study ◽  
In Pregnancy

Mitogen-Activated Protein Kinases Are Activated in Placental Injury in Rat Model of Acute Pancreatitis in Pregnancy

Pancreas ◽  
2016 ◽  
Vol 45 (6) ◽  
pp. 850-857 ◽  
Author(s):  
Teng Zuo ◽  
Jia Yu ◽  
Wei-xing Wang ◽  
Kai-liang Zhao ◽  
Chen Chen ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Protein Kinases ◽  
Rat Model ◽  
Mitogen Activated Protein Kinases ◽  
Mitogen Activated Protein ◽  
In Pregnancy

scholarly journals Role of Macrophage Migration Inhibitory Factor in Hepatitis B Virus-Specific Cytotoxic-T-Lymphocyte-Induced Liver Injury

2006 ◽  
Vol 13 (3) ◽  
pp. 415-419 ◽  
Author(s):  
Kiminori Kimura ◽  
Masahito Nagaki ◽  
Jun Nishihira ◽  
Shinichi Satake ◽  
Kazuo Kuwata ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Liver Injury ◽  
Hepatitis B ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Inflammatory Diseases ◽  
Inhibitory Factor ◽  
Macrophage Migration ◽  
Antibody Treatment ◽  
B Virus

ABSTRACT Macrophage migration inhibitory factor (MIF) plays a pivotal role in the development of various inflammatory diseases. Here, we found that anti-mouse MIF antibody treatment reduced liver injury and inflammatory cell infiltration into the liver after injection of antigen-specific cytotoxic T lymphocytes into hepatitis B virus transgenic mice.

scholarly journals Targeting Macrophage Migration Inhibitory Factor in Acute Pancreatitis and Pancreatic Cancer

2021 ◽  
Vol 12 ◽  
Author(s):  
Yongjian Wen ◽  
Wenhao Cai ◽  
Jingyu Yang ◽  
Xianghui Fu ◽  
Lohitha Putha ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Acute Pancreatitis ◽  
Signaling Pathways ◽  
Migration Inhibitory Factor ◽  
Chemokine Receptors ◽  
Macrophage Migration Inhibitory Factor ◽  
Inhibitory Factor ◽  
Great Promise ◽  
Macrophage Migration

Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine implicated in the pathogenesis of inflammation and cancer. It is produced by various cells and circulating MIF has been identified as a biomarker for a range of diseases. Extracellular MIF mainly binds to the cluster of differentiation 74 (CD74)/CD44 to activate downstream signaling pathways. These in turn activate immune responses, enhance inflammation and can promote cancer cell proliferation and invasion. Extracellular MIF also binds to the C-X-C chemokine receptors cooperating with or without CD74 to activate chemokine response. Intracellular MIF is involved in Toll-like receptor and inflammasome-mediated inflammatory response. Pharmacological inhibition of MIF has been shown to hold great promise in treating inflammatory diseases and cancer, including small molecule MIF inhibitors targeting the tautomerase active site of MIF and antibodies that neutralize MIF. In the current review, we discuss the role of MIF signaling pathways in inflammation and cancer and summarize the recent advances of the role of MIF in experimental and clinical exocrine pancreatic diseases. We expect to provide insights into clinical translation of MIF antagonism as a strategy for treating acute pancreatitis and pancreatic cancer.

scholarly journals Macrophage migration inhibitory factor is an early marker of severe acute pancreatitis based on the revised Atlanta classification

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Dingcheng Shen ◽  
Caixi Tang ◽  
Shuai Zhu ◽  
Gengwen Huang
Keyword(s):  
Acute Pancreatitis ◽  
Severe Acute Pancreatitis ◽  
Migration Inhibitory Factor ◽  
Predictive Value ◽  
Macrophage Migration Inhibitory Factor ◽  
Serum Markers ◽  
Apache Ii ◽  
Inhibitory Factor ◽  
Macrophage Migration ◽  
Early Marker

Abstract Background Various serum markers for early identification of severe acute pancreatitis (SAP) have been studied. Serum macrophage migration inhibitory factor (MIF) was reported to be correlated with severity of acute pancreatitis (AP) based on the 1992 Atlanta classification. However, MIF has never been proven to be predictive of disease severity based on the revised Atlanta classification (RAC). The potential predictive value of MIF needs to be further validated. Methods Consecutive patients with AP within 48 h after symptom onset and 10 healthy control volunteers were enrolled prospectively. Serum MIF levels were measured by enzyme-linked immunosorbent assay (ELISA). The predictive value of MIF, clinical scores and other serum markers were determined. Results Among 143 patients with AP, there were 52 (36.4%), 65 (45.5%) and 26 (18.1%) with mild, moderate and severe disease based on the RAC respectively. Compared with healthy volunteers, serum levels of MIF were significantly higher in AP patients, especially those with SAP (P < 0.001). Multivariate regression analysis indicated that increased serum MIF (cut-off 2.30 ng/ml, OR = 3.16, P = 0.008), IL-6 (cut-off 46.8 pg/ml, OR = 1.21, P = 0.043), APACHE II score (cut-off 7.5, OR = 2.57, P = 0.011) and BISAP score (cut-off 1.5, OR = 1.01, P = 0.038) were independent risk factors for predicting SAP (P < 0.05). By using the area under the receiver operating characteristic (ROC) curve (AUC), MIF (AUC 0.950) demonstrated more excellent discriminative power for predicting SAP than APACHE II (AUC 0.899), BISAP (AUC 0.886), and IL-6 (AUC 0.826). Conclusions Serum MIF is a valuable early marker for predicting the severity of AP based on the RAC.

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