Acetals moiety contained pH-sensitive amphiphilic copolymer self-assembly used for drug carrier

Polymer ◽  
2010 ◽  
Vol 51 (8) ◽  
pp. 1709-1715 ◽  
Author(s):  
Jushan Lu ◽  
Najun Li ◽  
Qingfeng Xu ◽  
Jianfeng Ge ◽  
Jianmei Lu ◽  
...  
Keyword(s):  
Self Assembly ◽  
Drug Carrier ◽  
Ph Sensitive ◽  
Amphiphilic Copolymer

scholarly journals Application of Mesoscale Simulation to Explore the pH Response of Eudragit S100 Used as the Novel Colon-Targeted Powder of Pulsatilla Saponin D

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Mingcheng Gong ◽  
Zhenhua Chen ◽  
Liangliang Zhou ◽  
Feng Gao ◽  
Jianxin Cheng ◽  
...  
Keyword(s):  
Self Assembly ◽  
Morphological Changes ◽  
Drug Carrier ◽  
Dissipative Particle Dynamics ◽  
Ph Sensitive ◽  
The Self ◽  
Coarse Grained ◽  
Release Mechanism ◽  
Eudragit S100 ◽  
Ph Conditions

As a pH-sensitive nanomaterial, Eudragit S100 has good colon targeting. However, little research has been carried out on its mesoscopic scale. In this paper, the self-assembly behavior of Pulsatilla saponins D (PSD) and Eudragit S100, as well as the loading and release mechanism of PSD, was investigated via computer simulations. The effects of the self-assembly characteristics of PSD and Eudragit S100 in the dry powder state on the drug-carrier ratio were explored by the coarse-grained molecular dynamics (CGMD) method. According to the pH-responsive feature of Eudragit S100, the drug protection under gastric pH conditions and release in colonic pH conditions were simulated through the dissipative particle dynamics (DPD) method, which has provided insights into the microscopic morphological changes in the pH-sensitive drug delivery systems.

Drug -driven self-assembly of pH-sensitive nano-vesicles with high loading capacity and anti-tumor efficacy

2021 ◽  
Author(s):  
Yaomin Zhai ◽  
Juan Wang ◽  
Liyan Qiu
Keyword(s):  
Growth Inhibition ◽  
Self Assembly ◽  
Drug Loading ◽  
Ph Sensitive ◽  
Amphiphilic Copolymer ◽  
Tumor Growth Inhibition ◽  
Loading Capacity ◽  
Inhibition Rate ◽  
High Drug ◽  
High Drug Loading

A pH-sensitive nano-vesicle was constructed by the drug-driven self-assembly of the amphiphilic copolymer PAP, which displayed a high drug loading capability of 35.77 wt% DOX·HCl and high tumor growth inhibition rate of up to 82.4% in mice.

scholarly journals Synthesis of pH-Sensitive Amphiphilic Copolymer Brush by the Combination of ARGET ATRP with ROP and Its Self-Assembly Behavior

2012 ◽  
Vol 70 (04) ◽  
pp. 505 ◽  
Author(s):  
Youqiang Yang ◽  
Qingqing Sun ◽  
Canyang Zhang ◽  
Xindong Guo ◽  
Lijuan Zhang ◽  
...  
Keyword(s):  
Self Assembly ◽  
Ph Sensitive ◽  
Amphiphilic Copolymer ◽  
Arget Atrp ◽  
Assembly Behavior ◽  
Copolymer Brush

pH-sensitive amphiphilic copolymer brush Chol-g-P(HEMA-co-DEAEMA)-b-PPEGMA: synthesis and self-assembled micelles for controlled anti-cancer drug release

RSC Advances ◽  
2014 ◽  
Vol 4 (76) ◽  
pp. 40232-40240 ◽  
Author(s):  
Can Yang Zhang ◽  
Wen Sheng Wu ◽  
Na Yao ◽  
Bin Zhao ◽  
Li Juan Zhang
Keyword(s):  
Drug Release ◽  
Drug Carrier ◽  
Ph Sensitive ◽  
Amphiphilic Copolymer ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Self Assembled ◽  
Copolymer Brush

A novel pH-sensitive amphiphilic copolymer Chol-g-P(HEMA-co-DEAEMA)-b-PPEGMA and its micelles were developed as a promising anti-cancer drug carrier.

scholarly journals Stereocomplex Polylactide for Drug Delivery and Biomedical Applications: A Review

Molecules ◽  
2021 ◽  
Vol 26 (10) ◽  
pp. 2846
Author(s):  
Seung Hyuk Im ◽  
Dam Hyeok Im ◽  
Su Jeong Park ◽  
Justin Jihong Chung ◽  
Youngmee Jung ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Drug Carrier ◽  
Micelle Formation ◽  
Weak Stability ◽  
Critical Fields ◽  
Physical Strength ◽  
Anti Cancer

Polylactide (PLA) is among the most common biodegradable polymers, with applications in various fields, such as renewable and biomedical industries. PLA features poly(D-lactic acid) (PDLA) and poly(L-lactic acid) (PLLA) enantiomers, which form stereocomplex crystals through racemic blending. PLA emerged as a promising material owing to its sustainable, eco-friendly, and fully biodegradable properties. Nevertheless, PLA still has a low applicability for drug delivery as a carrier and scaffold. Stereocomplex PLA (sc-PLA) exhibits substantially improved mechanical and physical strength compared to the homopolymer, overcoming these limitations. Recently, numerous studies have reported the use of sc-PLA as a drug carrier through encapsulation of various drugs, proteins, and secondary molecules by various processes including micelle formation, self-assembly, emulsion, and inkjet printing. However, concerns such as low loading capacity, weak stability of hydrophilic contents, and non-sustainable release behavior remain. This review focuses on various strategies to overcome the current challenges of sc-PLA in drug delivery systems and biomedical applications in three critical fields, namely anti-cancer therapy, tissue engineering, and anti-microbial activity. Furthermore, the excellent potential of sc-PLA as a next-generation polymeric material is discussed.

Chitosan Nanocarriers Loading Anti-Tumor Drugs

2015 ◽  
Vol 32 ◽  
pp. 113-127 ◽  
Author(s):  
Ji Wei Wu ◽  
Xin Feng Song ◽  
Han Wen Sun ◽  
Yan Cong Zhang ◽  
Xiang Ling Gu ◽  
...  
Keyword(s):  
Self Assembly ◽  
Drug Carrier ◽  
The Body ◽  
Natural Polymer ◽  
Preparation Methods ◽  
Ionic Crosslinking ◽  
Covalent Crosslinking ◽  
Immune Ability ◽  
Tumor Drugs ◽  
Adhesion Effect

Chitosan is a kind of natural polymer commonly applied for nanomaterials, which is affluent in nature with favorable biodegradability and biocompatibility and free of toxicity or odor. In clinic it can be used as a drug carrier for the treatment of cancer, and also it is a kind of new pharmaceutical excipient. To prepare chitosan nanomaterial, various method are used, such as ionic crosslinking, covalent crosslinking, precipitation, free radical polymerization, reverse micelle, spray drying, and self-assembly. Furthermore, plenty of anti-tumor drugs, including adriamycin, epirubicin, taxol, 5-fluorouracil, norcantharidin, folic acid, and so on, are also attempted to load on these chitosan nanocarriers. In addition, the mechanism for those nanocarriers carrying anti-tumor drugs acting on tumor cell were explored, and the formulation mainly include electric charge adhesion effect, suppressing the proliferation of tumor cells, adjusting or enhancing immune ability of the body and inducing apoptosis. This paper compared the characteristics of different preparation methods on chitosan as a nanodrug carrier, summarized the types of packaged drugs, analyzed the mechanism of the chitosan as nanodrug carriers. It can provide valuable reference for researchers' further work.

Construction of a pH-sensitive self-assembly in aqueous solutions based on a dansyl-modified β-cyclodextrin

Soft Matter ◽  
2021 ◽  
Author(s):  
Bing Jiang ◽  
Yu Liu ◽  
Linlin Zhao ◽  
Li Zhao ◽  
Ce Wang ◽  
...  
Keyword(s):  
Aqueous Solutions ◽  
Self Assembly ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Ph Range

Here we present a pH-responsive self-assembly based on a β-cyclodextrin (β-CD) derivative bearing a dansyl terminus (βCD-C6-Dns). Vesicular structures were formed over the entire studied pH range (8.5-0.7); however, the...

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