Drug -driven self-assembly of pH-sensitive nano-vesicles with high loading capacity and anti-tumor efficacy

2021 ◽  
Author(s):  
Yaomin Zhai ◽  
Juan Wang ◽  
Liyan Qiu
Keyword(s):  
Growth Inhibition ◽  
Self Assembly ◽  
Drug Loading ◽  
Ph Sensitive ◽  
Amphiphilic Copolymer ◽  
Tumor Growth Inhibition ◽  
Loading Capacity ◽  
Inhibition Rate ◽  
High Drug ◽  
High Drug Loading

A pH-sensitive nano-vesicle was constructed by the drug-driven self-assembly of the amphiphilic copolymer PAP, which displayed a high drug loading capability of 35.77 wt% DOX·HCl and high tumor growth inhibition rate of up to 82.4% in mice.

scholarly journals Efficient Self-Assembly of mPEG End-Capped Porous Silica as a Redox-Sensitive Nanocarrier for Controlled Doxorubicin Delivery

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Anh Khoa Nguyen ◽  
Thi Hiep Nguyen ◽  
Bui Quoc Bao ◽  
Long Giang Bach ◽  
Dai Hai Nguyen
Keyword(s):  
Self Assembly ◽  
Drug Loading ◽  
Porous Silica ◽  
Average Diameter ◽  
Burst Release ◽  
Loading Capacity ◽  
Potential Candidate ◽  
High Drug ◽  
Poly Ethylene ◽  
High Drug Loading

Porous nanosilica (PNS) has been regarded as a promising candidate for controlled delivery of anticancer drugs. Unmodified PNS-based nanocarriers, however, showed a burst release of encapsulated drugs, which may limit their clinical uses. In this report, PNS was surface conjugated with adamantylamine (ADA) via disulfide bridges (-SS-), PNS-SS-ADA, which was further modified with cyclodextrin-poly(ethylene glycol) methyl ether conjugate (CD-mPEG) to form a core@shell structure PNS-SS-ADA@CD-mPEG for redox triggered delivery of doxorubicin (DOX), DOX/PNS-SS-ADA@CD-mPEG. The prepared PNS-SS-ADA@CD-mPEG nanoparticles were spherical in shape with an average diameter of 55.5 ± 3.05 nm, a little larger than their parentally PNS nanocarriers, at 49.6 ± 2.56 nm. In addition, these nanoparticles possessed high drug loading capacity, at 79.2 ± 3.2%, for controlled release. The release of DOX from DOX/PNS-SS-ADA@CD-mPEG nanoparticles was controlled and prolonged up to 120 h in PBS medium (pH 7.4), compared to less than 40 h under reducing condition of 5 mM DTT. Notably, the PNS-SS-ADA@CD-mPEG was a biocompatible nanocarrier, and the toxicity of DOX was dramatically reduced after loading drugs into the porous core. This redox-sensitive PNS-SS-ADA@CD-mPEG nanoparticle could be considered a potential candidate with high drug loading capacity and a lower risk of systemic toxicity.

Design of dual-responsive nanocarries with high drug loading capacity based on hollow mesoporous organosilica nanoparticles

2019 ◽  
Vol 233 ◽  
pp. 230-235 ◽  
Author(s):  
Li-li Lu ◽  
Wen-ya Xiong ◽  
Jun-bin Ma ◽  
Tian-fang Gao ◽  
Si-yuan Peng ◽  
...  
Keyword(s):  
Drug Loading ◽  
Loading Capacity ◽  
High Drug ◽  
Dual Responsive ◽  
Mesoporous Organosilica ◽  
High Drug Loading

A novel high drug loading mussel-inspired polydopamine hybrid nanoparticle as a pH-sensitive vehicle for drug delivery

2017 ◽  
Vol 533 (1) ◽  
pp. 73-83 ◽  
Author(s):  
Jie Hou ◽  
Chunlei Guo ◽  
Yuzhi Shi ◽  
Ergang Liu ◽  
Weibing Dong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Loading ◽  
Ph Sensitive ◽  
High Drug ◽  
Hybrid Nanoparticle ◽  
High Drug Loading

scholarly journals Cancer Nanomedicines Stabilized by π-π Stacking between Heterodimeric Prodrugs Enable Exceptionally High Drug Loading Capacity and Safer Delivery of Drug Combinations

Theranostics ◽  
2017 ◽  
Vol 7 (15) ◽  
pp. 3638-3652 ◽  
Author(s):  
Hangxiang Wang ◽  
Jianmei Chen ◽  
Chang Xu ◽  
Linlin Shi ◽  
Munire Tayier ◽  
...  
Keyword(s):  
Drug Loading ◽  
Drug Combinations ◽  
Loading Capacity ◽  
High Drug ◽  
Π Stacking ◽  
High Drug Loading

A γ-cyclodextrin-based metal–organic framework embedded with graphene quantum dots and modified with PEGMA via SI-ATRP for anticancer drug delivery and therapy

Nanoscale ◽  
2019 ◽  
Vol 11 (43) ◽  
pp. 20956-20967 ◽  
Author(s):  
Qiaojuan Jia ◽  
Zhenzhen Li ◽  
Chuanpan Guo ◽  
Xiaoyu Huang ◽  
Yingpan Song ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Metal Organic Framework ◽  
Drug Loading ◽  
Graphene Quantum Dots ◽  
Tumor Growth Inhibition ◽  
High Drug ◽  
Anticancer Drug Delivery ◽  
Metal Organic ◽  
High Drug Loading

A biocompatible γ-CD-MOF based DDS with high drug loading and full drug release was prepared and effective tumor growth inhibition was achieved in vivo.

scholarly journals Synthesis and compatibility evaluation of versatile mesoporous silica nanoparticles with red blood cells: an overview

RSC Advances ◽  
2019 ◽  
Vol 9 (61) ◽  
pp. 35566-35578 ◽  
Author(s):  
Subhankar Mukhopadhyay ◽  
Hanitrarimalala Veroniaina ◽  
Tadious Chimombe ◽  
Lidong Han ◽  
Wu Zhenghong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Blood Cells ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
Loading Capacity ◽  
High Drug ◽  
High Drug Loading

Protean mesoporous silica nanoparticles are propitious candidates over decades for nanoscale drug delivery systems due to their unique characteristics, including changeable pore size, mesoporosity, high drug loading capacity and biodegradability.

High drug loading pH-sensitive pullulan-DOX conjugate nanoparticles for hepatic targeting

2013 ◽  
Vol 102 (1) ◽  
pp. 150-159 ◽  
Author(s):  
Huanan Li ◽  
Shaoquan Bian ◽  
Yihang Huang ◽  
Jie Liang ◽  
Yujiang Fan ◽  
...  
Keyword(s):  
Drug Loading ◽  
Ph Sensitive ◽  
High Drug ◽  
High Drug Loading

Magnetic carbon nanotubes with particle-free surfaces and high drug loading capacity

2011 ◽  
Vol 22 (35) ◽  
pp. 355602 ◽  
Author(s):  
Eleni C Vermisoglou ◽  
George Pilatos ◽  
George E Romanos ◽  
Eamon Devlin ◽  
Nick K Kanellopoulos ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Loading ◽  
Loading Capacity ◽  
Free Surfaces ◽  
High Drug ◽  
Magnetic Carbon ◽  
High Drug Loading ◽  
Magnetic Carbon Nanotubes

Water soluble multiarm-polyethylene glycol–betulinic acid prodrugs: design, synthesis, and in vivo effectiveness

2014 ◽  
Vol 5 (19) ◽  
pp. 5775-5783 ◽  
Author(s):  
Lin Dai ◽  
Dan Li ◽  
Jing Cheng ◽  
Jing Liu ◽  
Li-Hong Deng ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Betulinic Acid ◽  
Water Solubility ◽  
Drug Loading ◽  
Water Soluble ◽  
Loading Capacity ◽  
Design Synthesis ◽  
High Drug ◽  
High Drug Loading

Multiarm-polyethylene glycol–betulinic acid prodrugs were prepared by using multiarm-polyethylene glycol linkers and betulinic acid, which exhibited high drug loading capacity, good water solubility, and excellent anticancer activity.

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