Stearidonic acid combined with alpha-linolenic acid improves lipemic and neurological markers in a rat model subject to a hypercaloric diet

2018 ◽  
Vol 135 ◽  
pp. 137-146 ◽  
Author(s):  
Carlos Cardoso ◽  
Joana Paiva Martinho ◽  
Paula A. Lopes ◽  
Susana Martins ◽  
Jorge Correia ◽  
...  
Keyword(s):  
Linolenic Acid ◽  
Rat Model ◽  
Stearidonic Acid ◽  
Alpha Linolenic Acid ◽  
Model Subject ◽  
Hypercaloric Diet

scholarly journals Changes in the content of gamma-linolenic C18:3 (n-6) and stearidonic C18:4 (n-3) acids in developing seeds of viper's bugloss Echium vulgare L.

2007 ◽  
Vol 54 (4) ◽  
pp. 741-746 ◽  
Author(s):  
Andrzej Stolyhwo ◽  
Jolanta Mol
Keyword(s):  
Fatty Acids ◽  
Linolenic Acid ◽  
Seed Oil ◽  
Family Members ◽  
Stearidonic Acid ◽  
Alpha Linolenic Acid ◽  
Developing Seeds ◽  
Competitive Action

Changes in the composition of fatty acids (FA) were determined in lipid extracts isolated from developing ovaries containing ovules and developing seeds of Echium vulgare L. The samples were collected successively over 20 days beginning with the first day after flowering. The contents of the n-6 FA family members, i.e., gamma-linolenic (GLA) (C(18:3)) and linoleic (LA) (C(18:2)) acids changed in a parallel manner and reached the maximum of 13.9% and 24%, respectively, on the 12th day, after which they fell systematically down to 8.6% and 18.2%, respectively, on the 20th day after flowering. Starting with day 13, the content of alpha-linolenic acid (ALA) (C(18:3) n-3) begins to grow intensively, from 24.2% to 39.3% on the 20th day after flowering. The increase in the content of stearidonic acid (SDA) (C(18:4) n-3), up to 10.5% on the 20th day after flowering, occurred steadily as the seeds developed, and was independent of the changes in the content of GLA and LA. The pattern of changes in the content of SDA, GLA, LA and ALA during the development of seeds, and the occurrence of SDA in the seed oil of other plants, demonstrate that the biosynthesis of SDA in the seeds is critically dependent on the presence of ALA. The above condition indicates that SDA biosynthesis in the seeds of Echium vulgare follows the scheme LA --> simultaneous, competitive, action of Delta(6) and Delta(15) desaturases, leading to the formation of GLA and ALA, respectively, and then ALA (Delta(6) des) --> SDA. The biosynthesis according to the scheme: GLA (Delta(15) des) --> SDA is highly unlikely.

scholarly journals Genetic Modification of Mucor circinelloides to Construct Stearidonic Acid Producing Cell Factory

2019 ◽  
Vol 20 (7) ◽  
pp. 1683 ◽  
Author(s):  
Md. Khan ◽  
Junhuan Yang ◽  
Syed Hussain ◽  
Huaiyuan Zhang ◽  
Victoriano Garre ◽  
...  
Keyword(s):  
Linolenic Acid ◽  
Current Knowledge ◽  
Stearidonic Acid ◽  
Mucor Circinelloides ◽  
Cell Factory ◽  
Alpha Linolenic Acid ◽  
Homologous Overexpression ◽  
High Lipid ◽  
Oleaginous Fungus ◽  
Delta 6 Desaturase

Stearidonic acid (SDA; 18:4, n-3) is the delta 15-desaturase product of gamma linolenic acid (GLA; 18:3, n-6) and delta 6-desaturase product of alpha linolenic acid (ALA; 18:3, n-3). Construction of engineered oleaginous microbes have been attracting significant interest in producing SDA because of its nutritional value and pharmaceutical applications. Mucor circinelloides is a GLA producing filamentous fungus, which can be a useful tool to produce SDA. This study has, therefore, overexpressed the delta-15 desaturase (D15D) gene from Mortierella alpina in this fungus to construct a SDA-producing cell factory. To produce SDA in M. circinelloides, the homologous overexpression of D15D gene was analyzed. When the gene was overexpressed in M. circinelloides CBS 277.49, up to 5.0% SDA was accumulated in this strain. According to current knowledge, this is the first study describing the construction of a SDA-producing cell factory by overexpression of D15D gene in oleaginous fungus M. circinelloides. A new scope for further research has been established by this work to improve SDA production in this fungus, specifically in its high lipid-producing strain, WJ11.

Comparison of Ahiflower oil containing stearidonic acid to a high‐alpha‐linolenic acid flaxseed oil at two levels on tissue omega‐3 enrichment in broilers

Lipids ◽  
2021 ◽  
Author(s):  
Ahmed S. A. El‐Zenary ◽  
Khalid M. Gaafar ◽  
Reham Abou‐Elkhair ◽  
Robert G. Elkin ◽  
John W. Boney ◽  
...  
Keyword(s):  
Linolenic Acid ◽  
Stearidonic Acid ◽  
Flaxseed Oil ◽  
Omega 3 ◽  
Alpha Linolenic Acid

Production of γ-Linolenic Acid and Stearidonic Acid in Seeds of Marker-Free Transgenic Soybean

Crop Science ◽  
2004 ◽  
Vol 44 (2) ◽  
pp. 646 ◽  
Author(s):  
Shirley Sato ◽  
Aiqiu Xing ◽  
Xingguo Ye ◽  
Bruce Schweiger ◽  
Anthony Kinney ◽  
...  
Keyword(s):  
Linolenic Acid ◽  
Stearidonic Acid ◽  
Transgenic Soybean ◽  
Marker Free

Higher Oxidative Stability of Alpha-linolenic Acid Than Linoleic Acid in Nanoemulsions: a Comparison Between Bulk Flaxseed Oil and its O/W Nanoemulsions

2021 ◽  
Author(s):  
Masoomeh Zeinalzadegan ◽  
Maryam Nejadmansouri ◽  
Mohammad-Taghi Golmakani ◽  
Gholam Reza Mesbahi ◽  
David Julian McClements ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Oxidative Stability ◽  
Linolenic Acid ◽  
Flaxseed Oil ◽  
Alpha Linolenic Acid
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