The Effect of α-Linolenic Acid-Rich Emulsion on Fatty Acid Metabolism and Leukotriene Generation of the Colon in a Rat Model with Inflammatory Bowel Disease

1996 ◽  
Vol 40 (3) ◽  
pp. 175-182 ◽  
Author(s):  
Kenichi Inui ◽  
Yasuhiko Fukuta ◽  
Akira Ikeda ◽  
Hiromi Kameda ◽  
Yukifumi Kokuba ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Fatty Acid ◽  
Linolenic Acid ◽  
Fatty Acid Metabolism ◽  
Rat Model ◽  
Bowel Disease ◽  
Acid Metabolism ◽  
Alpha Linolenic Acid ◽  
Inflammatory Bowel

scholarly journals Alterations in intestinal fatty acid metabolism in inflammatory bowel disease

2006 ◽  
Vol 1762 (3) ◽  
pp. 341-350 ◽  
Author(s):  
Susanne Heimerl ◽  
Christoph Moehle ◽  
Alexandra Zahn ◽  
Alfred Boettcher ◽  
Wolfgang Stremmel ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Bowel Disease ◽  
Acid Metabolism ◽  
Inflammatory Bowel

Fatty Acid Metabolism in Broiler Chickens Fed Diets Either Rich in Linoleic or Alpha-Linolenic Acid

2011 ◽  
Vol 6 (3) ◽  
pp. 282-289 ◽  
Author(s):  
S. Wongsuthav ◽  
C. Yuangklang ◽  
K. Vasupen ◽  
J. Mitchaotha ◽  
A. Alhaidary ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Linolenic Acid ◽  
Fatty Acid Metabolism ◽  
Broiler Chickens ◽  
Acid Metabolism ◽  
Alpha Linolenic Acid

Vegetable oils rich in alpha linolenic acid increment hepatic n-3 LCPUFA, modulating the fatty acid metabolism and antioxidant response in rats

2016 ◽  
Vol 111 ◽  
pp. 25-35 ◽  
Author(s):  
Miguel Ángel Rincón-Cervera ◽  
Rodrigo Valenzuela ◽  
María Catalina Hernandez-Rodas ◽  
Cynthia Barrera ◽  
Alejandra Espinosa ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Linolenic Acid ◽  
Vegetable Oils ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Antioxidant Response ◽  
Alpha Linolenic Acid

Therapeutic Effect of Ribbon-Type Nuclear Factor-κB Decoy Oligonucleotides in a Rat Model of Inflammatory Bowel Disease

2012 ◽  
Vol 12 (6) ◽  
pp. 484-492 ◽  
Author(s):  
Kazunari Ozaki ◽  
Hirofumi Makino ◽  
Motokuni Aoki ◽  
Takashi Miyake ◽  
Natsuki Yasumasa ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Therapeutic Effect ◽  
Rat Model ◽  
Bowel Disease ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa ◽  
Inflammatory Bowel

Comparison of Bacterial Composition, Concentration, and Metabolism of Short Chain Fatty Acid in Inflammatory Bowel Disease: A Systematic Review

2021 ◽  
pp. 5978-5984
Author(s):  
David Nugraha ◽  
Natasya Ariesta Selyardi Putri ◽  
Visuddho Visuddho ◽  
Citrawati Dyah Kencono Wungu
Keyword(s):  
Systematic Review ◽  
Inflammatory Bowel Disease ◽  
Fatty Acid ◽  
Bowel Disease ◽  
Short Chain Fatty Acid ◽  
Chain Fatty Acid ◽  
Short Chain ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Inflammatory Bowel

Inflammatory bowel disease (IBD), which consists of Crohn's disease (CD) and ulcerative colitis (UC), is a chronic inflammatory disorder of the intestine. The etiology is heterogeneous and multifactorial, including genetic susceptibility, immune-mediated tissue damage, and changes of lumen microenvironment, especially short-chain fatty acid (SCFA) producing bacteria. Several studies reported a decrease in SCFA concentration in both CD and UC. In fact, SCFAs has important roles in accelerating disease remission. This systematic review aimed to evaluate the changes in SCFA concentration, the composition of SCFA-producing bacteria, and SCFA metabolism in IBD. A literature search was conducted via PubMed, Scopus, and CENTRAL by selecting studies according to inclusion and exclusion criteria. The quality and risk of bias assessment were performed using the Newcastle-Ottawa Scale (NOS). Overall, 160 UC and 127 CD patients from 5 studies were reviewed. The SCFA concentration was significantly reduced (p <0.05) in both PC and UC. Moreover, there was a decrease in major SCFA-producing bacteria. Clostridium coccoides were significantly decreased in the feces of active UC (p = 0.015) and CD (p = 0.04). Clostridium leptum was decreased on intestinal mucosal biopsy of active CD and UC (p <0.0001). Faecalibacterium prausnitzii were decreased in active CD faeces (p <0.0001) and UC (p = 0.0001). Butyrate oxidation rate was also reported to decrease in UC compared to control (p<0.0001). In conclusion, the ability of major SCFA-producing bacterial production in IBD was diminished, which implies a decreased protective and anti-inflammatory effect of SCFA that altered its metabolism.

Ginsenoside Rd therapy improves histological and functional recovery in a rat model of inflammatory bowel disease

2020 ◽  
Vol 34 (11) ◽  
pp. 3019-3028
Author(s):  
Ningning Yang ◽  
Guoying Liang ◽  
Jing Lin ◽  
Sijia Zhang ◽  
Qiuchi Lin ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Functional Recovery ◽  
Rat Model ◽  
Bowel Disease ◽  
Ginsenoside Rd ◽  
Inflammatory Bowel
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