Animal model of autism induced by prenatal exposure to valproate: Behavioral changes and liver parameters

2011 ◽  
Vol 1408 ◽  
pp. 8-16 ◽  
Author(s):  
Victorio Bambini-Junior ◽  
Leticia Rodrigues ◽  
Guilherme Antônio Behr ◽  
José Cláudio Fonseca Moreira ◽  
Rudimar Riesgo ◽  
...  
Keyword(s):  
Animal Model ◽  
Prenatal Exposure ◽  
Behavioral Changes ◽  
Liver Parameters

Effects of prenatal exposure to single-wall carbon nanotubes on reproductive performance and neurodevelopment in mice

2014 ◽  
Vol 32 (7) ◽  
pp. 1293-1301 ◽  
Author(s):  
Saeed Ivani ◽  
Isaac Karimi ◽  
Seyed Reza Fatemi Tabatabaei ◽  
Leila Syedmoradi
Keyword(s):  
Carbon Nanotubes ◽  
Prenatal Exposure ◽  
Motor Development ◽  
Behavioral Changes ◽  
Single Wall Carbon Nanotubes ◽  
Control Group ◽  
Plus Maze ◽  
Righting Reflex ◽  
Novel Drug ◽  
Walled Carbon Nanotubes

Carbon nanotubes with extraordinary properties may become a novel drug and gene delivery tool in nanomedicine; however, insufficient information is available regarding their biosafety. Therefore, this work was performed to study the effect of prenatal exposure of single-walled carbon nanotubes (SWCNTs) on reproductive and neurobehavioral endpoints in mice. Thirty pregnant female mice were assigned to three groups ( n = 10 for each group). The two treated groups were injected intraperitoneally (i.p.) with 1 or 10 mg/kg body weight (b.w.) of SWCNTs suspended in 1 ml of phosphate buffer saline (PBS) on gestational days 0 and 3. The control group was injected i.p. with an equal volume of PBS. The neurobehavioral ontogeny of pups was evaluated using a modified Fox battery. A decrease in litter size on postnatal day 2 was observed in the group treated with 10 mg/kg b.w. of SWCNTs whereas no significant differences between groups were observed in any other parameters. The behavioral development of pups did not show significant differences during growth except for the surface righting reflex, which showed significant delay compared to control in the group treated with 1 mg/kg b.w. SWCNTs. Moreover, exposed offspring (10 mg/kg b.w. SWCNTs) displayed enhanced anxiety in the elevated plus maze; however, other ethological analysis (Morris water maze and open field test) did not show behavioral changes in the experimental groups. In conclusion, the present results demonstrated small changes in offspring sensory and motor development following exposure to SWCNTs and support the idea that SWCNT risk assessment merits further investigation.

Effect of Serotonin-1A receptor on behavioral changes in animal model of schizophrenia-like behavior

2008 ◽  
Vol 23 ◽  
pp. S61
Author(s):  
V. Bubenikova-Valesova ◽  
M. Votava ◽  
T. Palenicek ◽  
J. Horacek ◽  
C. Hoschl
Keyword(s):  
Animal Model ◽  
Behavioral Changes ◽  
Serotonin 1A Receptor

Nigral But Not Striatal Grafts the Subthalamic Nuceus Produce Behavioral Changes in an Animal Model of Parkinson's Disease

Neurosurgery ◽  
1997 ◽  
Vol 41 (3) ◽  
pp. 723-724
Author(s):  
Craig van Horne ◽  
Servet Eken ◽  
Barry Hoffer ◽  
Anne-Charlotte Granholm
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Animal Model ◽  
Behavioral Changes ◽  
Striatal Grafts

scholarly journals Sertraline Induces Toxicity and Behavioral Alterations in Planarians

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Isabela Salvador Thumé ◽  
Marcos Emílio Frizzo
Keyword(s):  
Animal Model ◽  
Tissue Damage ◽  
Cell Types ◽  
Behavioral Changes ◽  
Locomotory Activity ◽  
Behavioral Alterations ◽  
Spontaneous Movement ◽  
Rapid Reduction ◽  
Different Cell Types

Toxicity attributed to sertraline has been demonstrated recently in different cell types and also in some organisms. We investigated the effect of sertraline on planarians, which are considered suitable for investigations in neurotoxicology and currently are widely used as an animal model in neuropharmacological studies. Planarians treated with 10 µM sertraline showed a rapid reduction in their spontaneous movement until they became completely motionless and then showed a series of asynchronous paroxysms (seizures) followed by progressive tissue damage, beginning 48 h after the sertraline treatment, and died approximately 72 h later. Our data showed that sertraline does not cause planarian death within the range of therapeutic concentrations; however, behavioral alterations were observed with concentrations that can be considered compatible with therapeutic ones, such as a significant reduction in planarian locomotory activity at 0.4 µM. Treatment with 4 µM sertraline had a significant effect, reducing planarian locomotory activity and increasing the number of asynchronous paroxysms; both effects were significantly maintained even 24 h after the sertraline was withdrawn. These behavioral changes observed at low micromolar concentrations suggest that sertraline might have residual biological consequences for planarians, even after it is withdrawn.

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