Prenatal stress decreases spatial learning and memory retrieval of the adult male offspring of rats

2014 ◽  
Vol 129 ◽  
pp. 104-109 ◽  
Author(s):  
Fatemeh Modir ◽  
Mahmoud Elahdadi Salmani ◽  
Iran Goudarzi ◽  
Taghi Lashkarboluki ◽  
Kataneh Abrari
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Adult Male ◽  
Prenatal Stress ◽  
Memory Retrieval ◽  
Male Offspring ◽  
Spatial Learning And Memory

scholarly journals Effects of testosterone on spatial learning and memory in adult male rats

2011 ◽  
Vol 59 (4) ◽  
pp. 484-496 ◽  
Author(s):  
Mark D. Spritzer ◽  
Emily D. Daviau ◽  
Meagan K. Coneeny ◽  
Shannon M. Engelman ◽  
W. Tyler Prince ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Adult Male ◽  
Male Rats ◽  
Spatial Learning And Memory

P4-253: Hilar GABAergic interneuron activity controls spatial learning and memory retrieval

2012 ◽  
Vol 8 (4S_Part_20) ◽  
pp. S747-S747
Author(s):  
Yaisa Andrews-Zwilling ◽  
Anna Gillespie ◽  
Alexxai Kravitz ◽  
Alexandra Nelson ◽  
Nino Devidze ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Memory Retrieval ◽  
Gabaergic Interneuron ◽  
Spatial Learning And Memory ◽  
Interneuron Activity

scholarly journals The effect of intra-nucleus accumbens shell injection of ascorbic acid on spatial learning and memory in adult male rats

2015 ◽  
Vol 2 (1) ◽  
pp. 73-81
Author(s):  
Fateme Shahsavari ◽  
Mahdi Abbasnejhad ◽  
Reihane Naderi ◽  
Saeed Esmaeeli Mahani ◽  
◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Nucleus Accumbens ◽  
Learning And Memory ◽  
Spatial Learning ◽  
Adult Male ◽  
Male Rats ◽  
Spatial Learning And Memory ◽  
Nucleus Accumbens Shell

scholarly journals Prenatal Stress Induced Spatial Memory Deficit in a Sex-Specific Manner in Mice: Possible Involvement of Hippocampal Insulin Resistance

2021 ◽  
Author(s):  
Massomeh Mohammadi ◽  
◽  
Ali Haeri-Rohani ◽  
Parichehr Yaghmaei ◽  
Hedayat Sahraei ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Learning And Memory ◽  
Spatial Learning ◽  
Prenatal Stress ◽  
Insulin Receptors ◽  
Memory Deficit ◽  
Spatial Learning And Memory ◽  
Control Male ◽  
Control Female ◽  
Learning And Memory Deficit

Introduction: In the present study, the effects of prenatal stress on spatial learning and memory deficit and its relationship with hippocampal insulin resistance was examined in male and female offspring. Method: Female NMRI mice were mate with males overnight and the zero day of pregnancy was detected (Gestational day zero-GD0). The pregnant mice were then randomly divided into stress and control groups. The stress group received stress from the GD0 to GD10. On post natal day 30 (PND30) the offspring were divided into for subgroups namely: male-control, female-control, male-stress, and female-stress. Barnes maze (BM) method was used for spatial learning evaluation. Plasma cortisol and insulin levels were measured at the beginning of the experiments. At the end of the experiments, the animals’ brains were removed and their hippocampus was extracted. The hippocampus was homogenized and its insulin and insulin receptor contents were evaluated. Results: The stressed animals needed more time for reaching to target hole. In addition, they spend more distance for finding the target hole, which was more pronounced in the male offspring. Both plasma and hippocampal insulin content were reduced in stressed groups. Moreover, the hippocampal insulin receptors protein was reduced in the stressed animals. There was a positive relationship between plasma and hippocampal content and memory deficit in the stressed groups. Conclusion: These results indicated that prenatal stress can induce spatial learning and memory deficit in offspring which is associated with plasma and hippocampal insulin and receptor content reduction (hippocampal insulin resistance) in these animals.

Hippocampal mechanisms in impaired spatial learning and memory in male offspring of rats fed a low-protein isocaloric diet in pregnancy and/or lactation

Hippocampus ◽  
2017 ◽  
Vol 28 (1) ◽  
pp. 18-30 ◽  
Author(s):  
L. A. Reyes-Castro ◽  
E. Padilla-Gómez ◽  
N. J. Parga-Martínez ◽  
D. C. Castro-Rodríguez ◽  
G. L. Quirarte ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Male Offspring ◽  
Spatial Learning And Memory ◽  
Isocaloric Diet ◽  
Low Protein ◽  
In Pregnancy
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