Hippocampal mechanisms in impaired spatial learning and memory in male offspring of rats fed a low-protein isocaloric diet in pregnancy and/or lactation

Hippocampus ◽  
2017 ◽  
Vol 28 (1) ◽  
pp. 18-30 ◽  
Author(s):  
L. A. Reyes-Castro ◽  
E. Padilla-Gómez ◽  
N. J. Parga-Martínez ◽  
D. C. Castro-Rodríguez ◽  
G. L. Quirarte ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Male Offspring ◽  
Spatial Learning And Memory ◽  
Isocaloric Diet ◽  
Low Protein ◽  
In Pregnancy

Prenatal stress decreases spatial learning and memory retrieval of the adult male offspring of rats

2014 ◽  
Vol 129 ◽  
pp. 104-109 ◽  
Author(s):  
Fatemeh Modir ◽  
Mahmoud Elahdadi Salmani ◽  
Iran Goudarzi ◽  
Taghi Lashkarboluki ◽  
Kataneh Abrari
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Adult Male ◽  
Prenatal Stress ◽  
Memory Retrieval ◽  
Male Offspring ◽  
Spatial Learning And Memory

scholarly journals GABAB receptor antagonist promotes hippocampal neurogenesis and facilitates cognitive function recovery following acute cerebral ischemia in mice

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Dan Song ◽  
Yaohua Chen ◽  
Cheng Chen ◽  
Lili Chen ◽  
Oumei Cheng
Keyword(s):  
Cognitive Function ◽  
Cerebral Ischemia ◽  
Learning And Memory ◽  
Spatial Learning ◽  
Hippocampal Neurogenesis ◽  
Morris Water Maze Test ◽  
Spatial Learning And Memory ◽  
In Vitro Experiments ◽  
Adult Mice

Abstract Purpose and background Previous studies have suggested that promoting endogenous neurogenesis has great significance for the recovery of cognitive dysfunction caused by cerebral ischemia (CI). Pharmacological inhibition of GABAB receptor can enhance neurogenesis in adult healthy and depressed mice. In the study, we intended to investigate the effects of GABAB receptor antagonists on cognitive function and hippocampal neurogenesis in mice following CI. Methods Adult mice were subjected to bilateral common carotid artery occlusion (BCCAO) for 20 min to induce CI and treated with CGP52432 (antagonist of GABAB receptor, CGP, 10 mg/kg intraperitoneal injection) starting 24 h after CI. The Morris water maze test was performed to test spatial learning and memory at day 28. Immunofluorescence was applied to detect neurogenesis in the DG region at day 14 and 28. In in vitro experiments, cell proliferation was detected by CCK8 and immunofluorescence, and the expression of cAMP/CREB signaling pathway-related proteins was detected by ELISA assay and Western blot. Results CGP significantly improved spatial learning and memory disorders caused by CI, and it enhanced the proliferation of neural stem cells (NSCs), the number of immature neurons, and the differentiation from newborn cells to neurons. In vitro experiments further confirmed that CGP dose-dependently enhanced the cell viability of NSCs, and immunofluorescence staining showed that CGP promoted the proliferation of NSCs. In addition, treatment with CGP increased the expression of cAMP, PKA, and pCREB in cultured NSCs. Conclusion Inhibition of GABAB receptor can effectively promote hippocampal neurogenesis and improve spatial learning and memory in adult mice following CI.

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