Anastrozole improved testosterone-induced impairment acquisition of spatial learning and memory in the hippocampal CA1 region in adult male rats

2006 ◽  
Vol 175 (2) ◽  
pp. 223-232 ◽  
Author(s):  
Farshad Moradpour ◽  
Nasser Naghdi ◽  
Yaghob Fathollahi
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Adult Male ◽  
Male Rats ◽  
Spatial Learning And Memory ◽  
Ca1 Region ◽  
Hippocampal Ca1 Region ◽  
Hippocampal Ca1

scholarly journals Reappearance of Hippocampal CA1 Neurons after Ischemia is Associated with Recovery of Learning and Memory

2005 ◽  
Vol 25 (12) ◽  
pp. 1586-1595 ◽  
Author(s):  
Olof Bendel ◽  
Tjerk Bueters ◽  
Mia von Euler ◽  
Sven Ove Ögren ◽  
Johan Sandin ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Learning And Memory ◽  
Spatial Learning ◽  
Cognitive Functions ◽  
Spatial Learning And Memory ◽  
Neuronal Marker ◽  
Ca1 Neurons ◽  
Ca1 Region ◽  
Hippocampal Ca1 ◽  
The Brain

The pyramidal neurons of the hippocampal CA1 region are essential for cognitive functions such as spatial learning and memory, and are selectively destroyed after cerebral ischemia. To analyze whether degenerated CA1 neurons are replaced by new neurons and whether such regeneration is associated with amelioration in learning and memory deficits, we have used a rat global ischemia model that provides an almost complete disappearance (to approximately 3% of control) of CA1 neurons associated with a robust impairment in spatial learning and memory at two weeks after ischemia. We found that transient cerebral ischemia can evoke a massive formation of new neurons in the CA1 region, reaching approximately 40% of the original number of neurons at 90 days after ischemia (DAI). Co-localization of the mature neuronal marker neuronal nuclei with 5-bromo-2'-deoxyuridine in CA1 confirmed that neurogenesis indeed had occurred after the ischemic insult. Furthermore, we found increased numbers of cells expressing the immature neuron marker polysialic acid neuronal cell adhesion molecule in the adjacent lateral periventricular region, suggesting that the newly formed neurons derive from this region. The reappearance of CA1 neurons was associated with a recovery of ischemia-induced impairments in spatial learning and memory at 90 DAI, suggesting that the newly formed CA1 neurons restore hippocampal CA1 function. In conclusion, these results show that the brain has an endogenous capacity to form new nerve cells after injury, which correlates with a restoration of cognitive functions of the brain.

scholarly journals Effects of testosterone on spatial learning and memory in adult male rats

2011 ◽  
Vol 59 (4) ◽  
pp. 484-496 ◽  
Author(s):  
Mark D. Spritzer ◽  
Emily D. Daviau ◽  
Meagan K. Coneeny ◽  
Shannon M. Engelman ◽  
W. Tyler Prince ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Adult Male ◽  
Male Rats ◽  
Spatial Learning And Memory

scholarly journals The effect of intra-nucleus accumbens shell injection of ascorbic acid on spatial learning and memory in adult male rats

2015 ◽  
Vol 2 (1) ◽  
pp. 73-81
Author(s):  
Fateme Shahsavari ◽  
Mahdi Abbasnejhad ◽  
Reihane Naderi ◽  
Saeed Esmaeeli Mahani ◽  
◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Nucleus Accumbens ◽  
Learning And Memory ◽  
Spatial Learning ◽  
Adult Male ◽  
Male Rats ◽  
Spatial Learning And Memory ◽  
Nucleus Accumbens Shell

EGB1212 Post-treatment Ameliorates Hippocampal CA1 Neuronal Death and Memory Impairment Induced by Transient Global Cerebral Ischemia/Reperfusion

2013 ◽  
Vol 41 (06) ◽  
pp. 1329-1341 ◽  
Author(s):  
Bo Yin ◽  
Hui Liang ◽  
Yigang Chen ◽  
Ketan Chu ◽  
Li Huang ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Learning And Memory ◽  
Spatial Learning ◽  
Ischemia Reperfusion ◽  
Clinical Applications ◽  
Post Treatment ◽  
Global Cerebral Ischemia ◽  
Spatial Learning And Memory ◽  
Cerebral Ischemia Reperfusion ◽  
Hippocampal Ca1

Extracts of Ginkgo biloba have been used in traditional medicines for centuries, and have potential for clinical applications in cerebral ischemia/reperfusion injury. However, standardized extracts have proven protective only as pre-treatments, and the major mechanisms of action remain unclear. We explored the potential of the novel extract EGB1212, which meets the United States Pharmacopeia (USP) 31 standardization criteria for pharmaceutical use, as a post-treatment after global cerebral ischemia/reperfusion (GCI/R) injury in a rat model. The pre-treated group was administered EGB1212 for 7 d prior to common carotid artery occlusion (i.e., ischemia, for 20 min). Post-treated rats received the same but starting 2 h after ischemia and continuing for 7 d. Seven days after GCI/R, brains of each group were processed for H&E staining of hippocampal CA1 neurons. Remaining rats underwent the Morris water maze and Y-maze tests of spatial learning and memory, beginning eight days after reperfusion. To assess hippocampal autophagy, light chain (LC)-3-I/LC3-II and Akt/pAkt were determined via a Western blot of rat hippocampi harvested 12, 24, or 72 h after reperfusion. EGB1212 pre- and post-treatments both improved neuronal survival and spatial learning and memory functions. Pre-treatment effectively reduced LC3-II levels and post-treatment resulted in significantly elevated pAkt levels. We conclude that EGB1212 exerted significant neuroprotection in GCI/R in both preventative and post-treatment settings. This extract shows great potential for clinical applications.

scholarly journals Enhanced Hippocampal CA1 LTP but Normal Spatial Learning in Inositol 1,4,5-trisphosphate 3-kinase(A)-Deficient Mice

1998 ◽  
Vol 5 (4) ◽  
pp. 317-330 ◽  
Author(s):  
Kisun Jun ◽  
Gildon Choi ◽  
Sung-Gu Yang ◽  
Kwan Yong Choi ◽  
Hyun Kim ◽  
...  
Keyword(s):  
Spatial Learning ◽  
Mutant Mice ◽  
Wild Type ◽  
Ca1 Region ◽  
Hippocampal Ca1 Region ◽  
Hippocampal Ca1 ◽  
Morris Water Maze Task ◽  
Significant Difference ◽  
Kinase A

To define the physiological role of IP33-kinase(A) in vivo, we have generated a mouse strain with a null mutation of the IP33-kinase(A) locus by gene targeting. Homozygous mutant mice were fully viable, fertile, apparently normal, and did not show any morphological anomaly in brain sections. In the mutant brain, the IP4 level was significantly decreased whereas the IP3 level did not change, demonstrating a major role of IP33-kinase(A) in the generation of IP4. Nevertheless, no significant difference was detected in the hippocampal neuronal cells of the wild-type and the mutant mice in the kinetics of Ca2+ regulation after glutamate stimulation. Electrophysiological analyses carried out in hippocampal slices showed that the mutation significantly enhanced the LTP in the hippocampal CA1 region, but had no effect on the LTP in dentate gyrus (DG). No difference was noted, however, between the mutant and the wild-type mice in the Morris water maze task. Our results indicate that IP33-kinase(A) may play an important role in the regulation of LTP in hippocampal CA1 region through the generation of IP4, but the enhanced LTP in the hippocampal CA1 does not affect spatial learning and memory.

scholarly journals Genistein improves spatial learning and memory in male rats with elevated glucose level during memory consolidation

2015 ◽  
Vol 140 ◽  
pp. 15-22 ◽  
Author(s):  
Yumi Kohara ◽  
Shinichiro Kawaguchi ◽  
Rika Kuwahara ◽  
Yutaro Uchida ◽  
Yushi Oku ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Glucose Level ◽  
Spatial Learning ◽  
Memory Consolidation ◽  
Male Rats ◽  
Spatial Learning And Memory ◽  
Elevated Glucose
Sign in / Sign up

Export Citation Format

Share Document