Serum MMP-8, -9 and TIMP-1 in sepsis: High serum levels of MMP-8 and TIMP-1 are associated with fatal outcome in a multicentre, prospective cohort study. Hypothetical impact of tetracyclines

2011 ◽  
Vol 64 (6) ◽  
pp. 590-594 ◽  
Author(s):  
Anneli Lauhio ◽  
Johanna Hästbacka ◽  
Ville Pettilä ◽  
Taina Tervahartiala ◽  
Sari Karlsson ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Fatal Outcome ◽  
Serum Levels ◽  
High Serum

scholarly journals Serum Levels of Apolipoproteins and Incident Type 2 Diabetes: A Prospective Cohort Study

Diabetes Care ◽  
2016 ◽  
Vol 40 (3) ◽  
pp. 346-351 ◽  
Author(s):  
Adela Brahimaj ◽  
Symen Ligthart ◽  
M. Arfan Ikram ◽  
Albert Hofman ◽  
Oscar H. Franco ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Serum Levels ◽  
Incident Type ◽  
Incident Type 2 Diabetes

scholarly journals Dynamics of Interleukin-10 Levels in Chronic Rhinosinusitis with/without Allergy

2015 ◽  
Vol 7 (3) ◽  
pp. 163
Author(s):  
Abdul Qadar Punagi ◽  
Sutji Pratiwi Rahardjo
Keyword(s):  
Cohort Study ◽  
Chronic Rhinosinusitis ◽  
Inflammatory Cytokines ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Treatment Approach ◽  
Specific Treatment ◽  
Serum Levels ◽  
Interleukin 10 ◽  
Persistent Problem

BACKGROUND: Rhinosinusitis occurs when the lining of the nasal and sinuses gets inflamed, infected or irritated, become swollen, and create extra mucus, the swollen lining may also interfere with drainage of mucus. Chronic rhinosinusitis (CRS) is a more persistent problem that requires a specific treatment approach. Aim of this study was to determine changes in interleukin (IL)-10 as an anti-inflammatory cytokines in allergic and non-allergic CRS at Makassar. METHODS: A prospective cohort study was designed to assess the level of IL-10 for three times during two weeks of therapy. Medication of Cefadroxil 500 mg 2x1, Pseudoephedrine 30 mg 2x1, Terfenadine 40 mg 2x1 and Methylprednisolone 4 mg 3x1, was conducted during two weeks for 13 subjects in allergic CRS group and 12 subjects in non-allergic CRS group. Results were statistically analyzed with student t-test and paired t-test.RESULTS: The changes in levels of IL-10 in allergic CRS group were increased, but not significant (5.293 to 5.769, p=0.058), and in non-allergic CRS group were decreased, but not significant (6.125 to 5.475, p=0.103). CONCLUSION: The serum levels of IL-10 were not significant increased in allergic CRS group and not significant decreased in non-allergic CRS group. KEYWORDS: interleukin-10, chronic rhinosinusitis, allergy, cefadroxil, pseudoephedrine, terfenadine, methylprednisolone

scholarly journals Multimorbidity patterns in chronic older patients, potentially inappropriate prescribing and adverse drug reactions: protocol of the multicentre prospective cohort study MoPIM

BMJ Open ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. e033322
Author(s):  
Marisa Baré ◽  
Susana Herranz ◽  
Rosa Jordana ◽  
Maria Queralt Gorgas ◽  
Sara Ortonobes ◽  
...  
Keyword(s):  
Cohort Study ◽  
Adverse Drug Reactions ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Older Patients ◽  
Screening Tool ◽  
Inappropriate Prescribing ◽  
Fatal Outcome ◽  
Potentially Inappropriate Prescribing ◽  
Drug Reactions

IntroductionMultimorbidity is a major challenge for current healthcare systems and professionals. From the different approaches that have been proposed to analyse this issue, the hypothesis of the existence of association patterns of different chronic conditions is gaining visibility. In addition, multimorbidity can be associated to polypharmacy, which can lead to a higher risk of potentially inappropriate prescribing (PIP) and consequently to adverse drug reactions (ADRs). The general objective of this novel study is to identify the association between PIP, multimorbidity patterns, polypharmacy and the presence of ADRs in older patients admitted for exacerbation of chronic diseases.Methods and analysisThe MoPIM (morbidity, potentially inappropriate medication) study is a multicentre prospective cohort study of an estimated sample of 800 older (≥65 years) patients admitted to five general hospitals in Spain due to an exacerbation of a chronic disease. Patients referred to home hospitalisation, admitted due to an acute process or with a fatal outcome expected at the time of admission are excluded. Sociodemographic data, chronic morbidities and geriatric syndromes, number of chronic prescribed medications, PIP at admission to hospital and on discharge, according to the newest screening tool of older screening tool of older person's potentially inappropriate prescriptions/screening tool to alert doctors to right treatment criteria, and ADRs during hospitalisation are being collected. Multimorbidity patterns will be identified using cluster analyses techniques, and the frequency of polypharmacy, PIP and ADRs will be calculated. Finally, the possible relationship between those indicators will be identified through bivariate and multivariate analyses.Ethics and disseminationThe project has been approved by the clinical research ethics committees of each centre: Comité Ético de investigación Clínica del Parc Taulí, Comitè Ètic d'Investigació Clínica Osona per a la Recerca i Educació Sanitàries (FORES), Comité de Ètica de la Investigación con Medicamentos (CEIm)-Parc de Salut MAR, Comité Ético de Investigación Clínica de Euskadi, Comité de Ética de Investigación del Hospital Universitario de Canarias. The results will be actively and mainly disseminated through publication in peer-reviewed journals and communications in scientific conferences.Trial registration numberNCT02830425.

scholarly journals Fatal Outcome in Bacteremia is Characterized by High Plasma Cell Free DNA Concentration and Apoptotic DNA Fragmentation: A Prospective Cohort Study

PLoS ONE ◽  
2011 ◽  
Vol 6 (7) ◽  
pp. e21700 ◽  
Author(s):  
Reetta Huttunen ◽  
Taru Kuparinen ◽  
Juulia Jylhävä ◽  
Janne Aittoniemi ◽  
Risto Vuento ◽  
...  
Keyword(s):  
Cohort Study ◽  
Dna Fragmentation ◽  
Plasma Cell ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Fatal Outcome ◽  
High Plasma ◽  
Cell Free Dna ◽  
Dna Concentration ◽  
Free Dna
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