High serum fibroblast growth factor 21 is associated with inferior hepatocellular carcinoma survival: a prospective cohort study

2021 ◽  
Author(s):  
Zhaoyan Liu ◽  
Yan Luo ◽  
Aiping Fang ◽  
Maierhaba Wusiman ◽  
Tongtong He ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cohort Study ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
High Serum ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth

scholarly journals Epigenetic Regulation of Processes Related to High Level of Fibroblast Growth Factor 21 in Obese Subjects

Genes ◽  
2021 ◽  
Vol 12 (2) ◽  
pp. 307
Author(s):  
Teresa Płatek ◽  
Anna Polus ◽  
Joanna Góralska ◽  
Urszula Raźny ◽  
Agnieszka Dziewońska ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Epigenetic Regulation ◽  
Growth Factor Receptor ◽  
High Serum ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Differentially Methylated Genes ◽  
Obese Subjects

We hypothesised that epigenetics may play an important role in mediating fibroblast growth factor 21 (FGF21) resistance in obesity. We aimed to evaluate DNA methylation changes and miRNA pattern in obese subjects associated with high serum FGF21 levels. The study included 136 participants with BMI 27–45 kg/m2. Fasting FGF21, glucose, insulin, GIP, lipids, adipokines, miokines and cytokines were measured and compared in high serum FGF21 (n = 68) group to low FGF21 (n = 68) group. Human DNA Methylation Microarrays were analysed in leukocytes from each group (n = 16). Expression of miRNAs was evaluated using quantitative PCR-TLDA. The study identified differentially methylated genes in pathways related to glucose transport, insulin secretion and signalling, lipid transport and cellular metabolism, response to nutrient levels, thermogenesis, browning of adipose tissue and bone mineralisation. Additionally, it detected transcription factor genes regulating FGF21 and fibroblast growth factor receptor and vascular endothelial growth factor receptor pathways regulation. Increased expression of hsa-miR-875-5p and decreased expression of hsa-miR-133a-3p, hsa-miR-185-5p and hsa-miR-200c-3p were found in the group with high serum FGF21. These changes were associated with high FGF21, VEGF and low adiponectin serum levels. Our results point to a significant role of the epigenetic regulation of genes involved in metabolic pathways related to FGF21 action.

Fibroblast growth factor-21 predicts adverse outcome in community-acquired pneumonia

2018 ◽  
Author(s):  
Fahim Ebrahimi ◽  
Carole Wolffenbuttel ◽  
Claudine A Blum ◽  
Beat Muller ◽  
Philipp Schuetz ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Adverse Outcome ◽  
Community Acquired Pneumonia ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth

Effects of anti-inflammatory treatment on fibroblast growth factor-21 in obesity and metabolic syndrome

2019 ◽  
Author(s):  
Fahim Ebrahimi ◽  
Sandrine Urwyler ◽  
Matthias Betz ◽  
Emanuel Christ ◽  
Philipp Schuetz ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Anti Inflammatory

Fibroblast growth factor 21 (FGF21) in hyper- and hypothyroidism, association with metabolic disturbances

2020 ◽  
Author(s):  
Ewa Szczepańska ◽  
Małgorzata Gietka-Czernel ◽  
Piotr Glinicki ◽  
Helena Jastrzębska ◽  
Jadwiga Słowińska-Srzednicka ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Metabolic Disturbances
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