scholarly journals Serum Levels of Apolipoproteins and Incident Type 2 Diabetes: A Prospective Cohort Study

Diabetes Care ◽  
2016 ◽  
Vol 40 (3) ◽  
pp. 346-351 ◽  
Author(s):  
Adela Brahimaj ◽  
Symen Ligthart ◽  
M. Arfan Ikram ◽  
Albert Hofman ◽  
Oscar H. Franco ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Serum Levels ◽  
Incident Type ◽  
Incident Type 2 Diabetes

[beta]eta-hydroxybutyrate and risk for incident type 2 diabetes: results from the prevend prospective cohort study

2019 ◽  
Author(s):  
Jose L Flores-Guerrero ◽  
Margery A Connelly ◽  
Dion Groothof ◽  
Eke G Gruppen ◽  
Stephan JL Bakker ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Incident Type ◽  
Incident Type 2 Diabetes

scholarly journals Periodontitis and incident type 2 diabetes: a prospective cohort study

2017 ◽  
Vol 44 (3) ◽  
pp. 266-274 ◽  
Author(s):  
Lewis Winning ◽  
Christopher C. Patterson ◽  
Charlotte E. Neville ◽  
Frank Kee ◽  
Gerard J. Linden
Keyword(s):  
Type 2 Diabetes ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Incident Type ◽  
Incident Type 2 Diabetes

scholarly journals Erythrocyte n-6 Polyunsaturated Fatty Acids, Gut Microbiota, and Incident Type 2 Diabetes: A Prospective Cohort Study

Diabetes Care ◽  
2020 ◽  
Vol 43 (10) ◽  
pp. 2435-2443 ◽  
Author(s):  
Zelei Miao ◽  
Jie-sheng Lin ◽  
Yingying Mao ◽  
Geng-dong Chen ◽  
Fang-fang Zeng ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Cohort Study ◽  
Gut Microbiota ◽  
Polyunsaturated Fatty Acids ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Incident Type ◽  
Incident Type 2 Diabetes

scholarly journals Spousal diabetes status as a risk factor for incident type 2 diabetes: a prospective cohort study and meta-analysis

2019 ◽  
Vol 56 (6) ◽  
pp. 619-629 ◽  
Author(s):  
Duke Appiah ◽  
Pamela J. Schreiner ◽  
Elizabeth Selvin ◽  
Ellen W. Demerath ◽  
James S. Pankow
Keyword(s):  
Type 2 Diabetes ◽  
Risk Factor ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Meta Analysis ◽  
Incident Type ◽  
Diabetes Status ◽  
Incident Type 2 Diabetes

scholarly journals Change in fasting plasma glucose and incident type 2 diabetes mellitus: results from a prospective cohort study

BMJ Open ◽  
2016 ◽  
Vol 6 (5) ◽  
pp. e010889 ◽  
Author(s):  
Amirhossein Mozaffary ◽  
Samaneh Asgari ◽  
Maryam Tohidi ◽  
Sara Kazempour-Ardebili ◽  
Fereidoun Azizi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cohort Study ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Prospective Cohort ◽  
Incident Type ◽  
Incident Type 2 Diabetes

scholarly journals Associations between grip strength and incident type 2 diabetes: findings from the UK Biobank prospective cohort study

2021 ◽  
Vol 9 (1) ◽  
pp. e001865
Author(s):  
Jirapitcha Boonpor ◽  
Solange Parra-Soto ◽  
Fanny Petermann-Rocha ◽  
Gerson Ferrari ◽  
Paul Welsh ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Body Weight ◽  
Cohort Study ◽  
Grip Strength ◽  
Prospective Cohort ◽  
Uk Biobank ◽  
Incident Type ◽  
Incident Type 2 Diabetes ◽  
The Uk

IntroductionGrip strength has been associated with chronic diseases and mortality. However, current evidence of the association between grip strength and incident type 2 diabetes mellitus (T2DM) is controversial. The aim of this study was to investigate the associations of absolute and relative grip strength with incident T2DM and whether these associations differ by sociodemographic, lifestyle and adiposity-related factors.Research design and methodsThis was a prospective cohort study of 166 894 participants in the UK Biobank (mean age 56.5 years, 54.4% women). The outcome was T2DM incidence and the exposure was grip strength, expressed in absolute (kg) and relative (kg per kg of body weight) values. The association between grip strength and T2DM incidence was investigated using Cox-proportional regression.ResultsThe median follow-up was 5.3 years (IQR: 4.7–6.1). During this time, 3713 participants developed T2DM. Lower grip strength was associated with a higher risk of T2DM in both sexes. Those in the lowest quintile of absolute grip strength had a 50% higher risk in men (HR: 1.50 (95% CI: 1.30 to 1.73)) and 25% higher risk in women (HR: 1.25 (95% CI: 1.06 to 1.47)) compared with those in the highest quintile. For relative grip strength, risk of diabetes was more than double for men (HR: 2.22 (95% CI: 1.84 to 2.67)) and 96% higher for women (HR: 1.96 (95% CI: 1.52 to 2.53)) in the lowest compared with highest quintiles.ConclusionsGrip strength is associated with a higher risk of T2DM incidence in both men and women independent of important confounding factors including age, deprivation, adiposity and lifestyle. However, the associations were stronger when grip strength is expressed relative to body weight, which could reflect the importance of muscle quality.

scholarly journals RANTES/CCL5 gene polymorphisms, serum concentrations, and incident type 2 diabetes: results from the MONICA/KORA Augsburg case–cohort study, 1984–2002

2008 ◽  
Vol 158 (5) ◽  
pp. R1-R5 ◽  
Author(s):  
Christian Herder ◽  
Thomas Illig ◽  
Jens Baumert ◽  
Martina Müller ◽  
Norman Klopp ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cohort Study ◽  
Gene Polymorphisms ◽  
Serum Levels ◽  
Population Based ◽  
Nucleotide Polymorphisms ◽  
Serum Concentrations ◽  
Incident Type ◽  
Incident Type 2 Diabetes

ObjectiveRegulated on activation, normal T-cell expressed and secreted (RANTES)/chemokine(C-C motif) ligand (CCL5) is expressed by adipocytes, and serum levels of RANTES are increased in obesity and type 2 diabetes. The aim of this study was to test the hypothesis that RANTES is involved in the pathogenesis of type 2 diabetes by analyzing the triangular association between CCL5 gene polymorphisms, systemic RANTES concentrations, and incident type 2 diabetes in a large prospective study.Subjects and methodsThe study is based on 502 individuals (293 men and 209 women) and 1632 individuals (859 men and 773 women) with and without incident type 2 diabetes from the population-based MONItoring of Trends and Determinants in Cardiovascular Disease (MONICA)/Cooperative Health Research in the Region of Augsburg (KORA) case–cohort study respectively (mean follow-up time±s.d. 10.1±4.9 years). CCL5 genotypes and RANTES serum concentrations were determined and associations between genotypes, haplotypes, serum levels, and incident type 2 diabetes were assessed.ResultsMinor alleles of four single nucleotide polymorphisms were associated with lower RANTES levels (Padditive between 1.2×10−9 and 3.1×10−8), but neither genotypes, haplotypes, nor serum levels were associated with incident type 2 diabetes.ConclusionsOur data suggest that RANTES/CCL5 gene variants and serum levels are not causally related with type 2 diabetes and that elevated RANTES levels in patients with type 2 diabetes may be a consequence of hyperglycemia. However, our findings cannot preclude a local role in adipose tissue where RANTES expression may contribute to leukocyte infiltration and a proinflammatory state.

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