scholarly journals Prophylaxis and management of antineoplastic drug induced nausea and vomiting in children with cancer

2016 ◽  
Vol 1 (3) ◽  
pp. 50-55 ◽  
Author(s):  
Sidharth Totadri
Keyword(s):  
Nausea And Vomiting ◽  
Antineoplastic Drug ◽  
Children With Cancer ◽  
Drug Induced

scholarly journals Study on Medication Rules of Traditional Chinese Medicine against Antineoplastic Drug-Induced Cardiotoxicity Based on Network Pharmacology and Data Mining

2020 ◽  
Vol 2020 ◽  
pp. 1-15
Author(s):  
Wenchao Dan ◽  
Jinlei Liu ◽  
Xinyuan Guo ◽  
Boran Zhang ◽  
Yi Qu ◽  
...  
Keyword(s):  
Data Mining ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Target Prediction ◽  
Antineoplastic Drug ◽  
Matrix Metalloproteinase 2 ◽  
Network Pharmacology ◽  
China National Knowledge Infrastructure ◽  
Drug Induced ◽  
Mitogen Activated Protein

Background and Aim. Antineoplastic drug-induced cardiotoxicity (ADIC) becomes the second leading cause of death for tumor survivors after tumor recurrence and metastasis, and there may be great room for development in the future of traditional Chinese medicine (TCM). However, the theory of anticardiotoxicity of TCM has not yet formed a system. This study aimed to explore the material basis and the rule of TCM against ADIC based on network pharmacology and data mining. Methods. The targets of antineoplastic drugs with cardiotoxicity were obtained from the National Center for Biotechnology Information (NCBI) database, China national knowledge infrastructure (CNKI) database, and Swiss Target Prediction platform. Then, the cardiotoxicity-related targets were derived from the Gene Cards, Disgenet, OMIM, and DrugBank databases, as well as the drug of current clinical guidelines. The targets both in these two sets were regarded as potential targets to alleviate ADIC. Then, candidate compounds and herbs were matched via Traditional Chinese Medicine Systems Pharmacology (TCMSP) platform. Cytoscape3.7.1 was used to set up the target-compound-herb network. Molecular docking between core targets and compounds was performed with AutodockVina1.1.2. The rules of herbs were summarized by analyzing their property, flavor, and channel tropism. Results. Twenty-one potential targets, 332 candidate compounds, and 400 kinds of herbs were obtained. Five core targets including potassium voltage-gated channel subfamily H member 2 (KCNH2), cyclin-dependent kinase 1 (CDK1), matrix metalloproteinase 2 (MMP2), mitogen-activated protein kinase1 (MAPK1), and tumor protein p53 (TP53) and 29 core compounds (beta-sitosterol, quercetin, kaempferol, etc.) were collected. Five core herbs (Yanhusuo, Gouteng, Huangbai, Lianqiao, and Gancao) were identified. Also, the TCM against ADIC were mainly bitter and acrid in taste, warm in property, and distributed to the liver and lung meridians. Conclusion. TCM against ADIC has great potential. Our study provides a new method and ideas for clinical applications of integrated Chinese and western medicine in treating ADIC.

Marijuana for drug-induced nausea and vomiting

JAMA ◽  
1980 ◽  
Vol 243 (12) ◽  
pp. 1265-1265 ◽  
Author(s):  
D. L. Sweet
Keyword(s):  
Nausea And Vomiting ◽  
Drug Induced

scholarly journals Antineoplastic Drug-Induced Cardiotoxicity: A Redox Perspective

2018 ◽  
Vol 9 ◽  
Author(s):  
Gilda Varricchi ◽  
Pietro Ameri ◽  
Christian Cadeddu ◽  
Alessandra Ghigo ◽  
Rosalinda Madonna ◽  
...  
Keyword(s):  
Antineoplastic Drug ◽  
Drug Induced

Ginger for Prevention or Treatment of Drug-Induced Nausea and Vomiting

2014 ◽  
Vol 9 (4) ◽  
pp. 387-394 ◽  
Author(s):  
Fatemeh Dabaghzadeh ◽  
Hossein Khalili ◽  
Simin Dashti-Khavidaki
Keyword(s):  
Nausea And Vomiting ◽  
Drug Induced

Prophylaxis of acute chemotherapy-induced nausea and vomiting in children with cancer: What is the evidence?

2004 ◽  
Vol 43 (6) ◽  
pp. 651-658 ◽  
Author(s):  
Emmanuel S. Antonarakis ◽  
Jamie L. Evans ◽  
Gemma F. Heard ◽  
Lucy M. Noonan ◽  
Barry L. Pizer ◽  
...  
Keyword(s):  
Nausea And Vomiting ◽  
Children With Cancer
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