scholarly journals Antineoplastic Drug-Induced Cardiotoxicity: A Redox Perspective

2018 ◽  
Vol 9 ◽  
Author(s):  
Gilda Varricchi ◽  
Pietro Ameri ◽  
Christian Cadeddu ◽  
Alessandra Ghigo ◽  
Rosalinda Madonna ◽  
...  
Keyword(s):  
Antineoplastic Drug ◽  
Drug Induced

scholarly journals Study on Medication Rules of Traditional Chinese Medicine against Antineoplastic Drug-Induced Cardiotoxicity Based on Network Pharmacology and Data Mining

2020 ◽  
Vol 2020 ◽  
pp. 1-15
Author(s):  
Wenchao Dan ◽  
Jinlei Liu ◽  
Xinyuan Guo ◽  
Boran Zhang ◽  
Yi Qu ◽  
...  
Keyword(s):  
Data Mining ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Target Prediction ◽  
Antineoplastic Drug ◽  
Matrix Metalloproteinase 2 ◽  
Network Pharmacology ◽  
China National Knowledge Infrastructure ◽  
Drug Induced ◽  
Mitogen Activated Protein

Background and Aim. Antineoplastic drug-induced cardiotoxicity (ADIC) becomes the second leading cause of death for tumor survivors after tumor recurrence and metastasis, and there may be great room for development in the future of traditional Chinese medicine (TCM). However, the theory of anticardiotoxicity of TCM has not yet formed a system. This study aimed to explore the material basis and the rule of TCM against ADIC based on network pharmacology and data mining. Methods. The targets of antineoplastic drugs with cardiotoxicity were obtained from the National Center for Biotechnology Information (NCBI) database, China national knowledge infrastructure (CNKI) database, and Swiss Target Prediction platform. Then, the cardiotoxicity-related targets were derived from the Gene Cards, Disgenet, OMIM, and DrugBank databases, as well as the drug of current clinical guidelines. The targets both in these two sets were regarded as potential targets to alleviate ADIC. Then, candidate compounds and herbs were matched via Traditional Chinese Medicine Systems Pharmacology (TCMSP) platform. Cytoscape3.7.1 was used to set up the target-compound-herb network. Molecular docking between core targets and compounds was performed with AutodockVina1.1.2. The rules of herbs were summarized by analyzing their property, flavor, and channel tropism. Results. Twenty-one potential targets, 332 candidate compounds, and 400 kinds of herbs were obtained. Five core targets including potassium voltage-gated channel subfamily H member 2 (KCNH2), cyclin-dependent kinase 1 (CDK1), matrix metalloproteinase 2 (MMP2), mitogen-activated protein kinase1 (MAPK1), and tumor protein p53 (TP53) and 29 core compounds (beta-sitosterol, quercetin, kaempferol, etc.) were collected. Five core herbs (Yanhusuo, Gouteng, Huangbai, Lianqiao, and Gancao) were identified. Also, the TCM against ADIC were mainly bitter and acrid in taste, warm in property, and distributed to the liver and lung meridians. Conclusion. TCM against ADIC has great potential. Our study provides a new method and ideas for clinical applications of integrated Chinese and western medicine in treating ADIC.

scholarly journals An Overview of Pharmacological and Non–pharmacological Treatment as a Useful Tool for the Protection from Cardiotoxicity of Antineoplastic Drugs

2018 ◽  
Vol 0 (0) ◽  
Author(s):  
Tanja Radonjic ◽  
Nina Simonovic ◽  
Tamara Nikolic Turnic
Keyword(s):  
Pharmacological Treatment ◽  
Patient Survival ◽  
Antineoplastic Drug ◽  
Drug Induced ◽  
Cancer Disease ◽  
Future Studies ◽  
Patients With Cancer ◽  
Cardiac Evaluation ◽  
Herb Extracts

ABSTRACT Unfortunately, in patients with cancer disease, clinical application of antineoplastic drug results in severe side effects of cardiotoxicity. We aim to review the research focused on elimination or reduction of antineoplastic drug-induced cardiotoxicity without aff ecting its anticancer effi cacy by diff erent agens. Th is study is based on pertinent papers that were retrieved by a selective search using relevant keywords in PubMed and ScienceDirect. Based on mentioned purpose, various strategies were investigated and proposed, and thousands of compounds were screened. Th e literature mainly focusing on drugs, natural products and herb extracts with therapeutic effi cacies as well as non-pharmacological treatment against diff erently induced cardiotoxicity during treatment in patients with cancers. Larger future studies are necessary to reach a point of secure cytostatic therapy, improved patient survival and quality of life. Until that moment, baseline and serial cardiac evaluation is recommended to facilitate early identifi cation and treatment of cardiotoxicity.

scholarly journals From Molecular Mechanisms to Clinical Management of Antineoplastic Drug-Induced Cardiovascular Toxicity: A Translational Overview

2019 ◽  
Vol 30 (18) ◽  
pp. 2110-2153 ◽  
Author(s):  
Carlo Gabriele Tocchetti ◽  
Christian Cadeddu ◽  
Daniela Di Lisi ◽  
Saveria Femminò ◽  
Rosalinda Madonna ◽  
...  
Keyword(s):  
Clinical Management ◽  
Molecular Mechanisms ◽  
Antineoplastic Drug ◽  
Cardiovascular Toxicity ◽  
Drug Induced

Antineoplastic drug-induced bradyarrhythmias

2012 ◽  
Vol 11 (5) ◽  
pp. 739-751 ◽  
Author(s):  
Carla Minoia ◽  
Margherita Giannoccaro ◽  
Angela Iacobazzi ◽  
Daniele Santini ◽  
Nicola Silvestris ◽  
...  
Keyword(s):  
Antineoplastic Drug ◽  
Drug Induced

scholarly journals Strategies to reduce the risk of platinum containing antineoplastic drug-induced ototoxicity

2020 ◽  
Vol 16 (10) ◽  
pp. 965-982
Author(s):  
Debashree Mukherjea ◽  
Asmita Dhukhwa ◽  
Amit Sapra ◽  
Priyanka Bhandari ◽  
Katlyn Woolford ◽  
...  
Keyword(s):  
Antineoplastic Drug ◽  
Drug Induced

Early Development of Drug-Induced Hepatic Necrosis

1971 ◽  
Vol 29 ◽  
pp. 576-577
Author(s):  
F. G. Zaki ◽  
E. Detzi ◽  
C. H. Keysser
Keyword(s):  
Early Development ◽  
Hepatic Necrosis ◽  
Screening Tests ◽  
Dense Matrix ◽  
Sprague Dawley ◽  
Electron Microscopic ◽  
Drug Induced ◽  
Hepatocellular Damage ◽  
Sprague Dawley Rats ◽  
Microscopic Studies

This study represents the first in a series of investigations carried out to elucidate the mechanism(s) of early hepatocellular damage induced by drugs and other related compounds. During screening tests of CNS-active compounds in rats, it has been found that daily oral administration of one of these compounds at a dose level of 40 mg. per kg. of body weight induced diffuse massive hepatic necrosis within 7 weeks in Charles River Sprague Dawley rats of both sexes. Partial hepatectomy enhanced the development of this peculiar type of necrosis (3 weeks instead of 7) while treatment with phenobarbital prior to the administration of the drug delayed the appearance of necrosis but did not reduce its severity.Electron microscopic studies revealed that early development of this liver injury (2 days after the administration of the drug) appeared in the form of small dark osmiophilic vesicles located around the bile canaliculi of all hepatocytes (Fig. 1). These structures differed from the regular microbodies or the pericanalicular multivesicular bodies. They first appeared regularly rounded with electron dense matrix bound with a single membrane. After one week on the drug, these vesicles appeared vacuolated and resembled autophagosomes which soon developed whorls of concentric lamellae or cisterns characteristic of lysosomes (Fig. 2). These lysosomes were found, later on, scattered all over the hepatocytes.

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