The protective effect of grape skin or purple carrot extracts against cadmium intoxication in kidney of rats

2019 ◽  
Vol 26 (3-4) ◽  
pp. 263-269
Author(s):  
Samuel Rangel Claudio ◽  
Flavia Andressa Pidone Ribeiro ◽  
Eliene Cezario De Lima ◽  
Aline Boveto Santamarina ◽  
Luciana Pellegrini Pisani ◽  
...  
Keyword(s):  
Protective Effect ◽  
Grape Skin ◽  
Cadmium Intoxication

Protective Effect of Grape and Apple Juices against Cadmium Intoxication in the Kidney of Rats

Drug Research ◽  
2020 ◽  
Vol 70 (11) ◽  
pp. 503-511
Author(s):  
Bianca Andrade Handan ◽  
Carolina Foot Gomes De Moura ◽  
Caroline Margonato Cardoso ◽  
Aline Boveto Santamarina ◽  
Luciana Pellegrini Pisani ◽  
...  
Keyword(s):  
Protective Effect ◽  
Cadmium Chloride ◽  
Apple Juice ◽  
Tissue Injury ◽  
Grape Juice ◽  
Control Group ◽  
Histopathological Analysis ◽  
Gene Expressions ◽  
Cadmium Intoxication ◽  
Male Wistar Rats

Abstract Background The objective of this study was to evaluate protective effect of grape and apple juices against toxicity induced by cadmium in the kidney of rats. Methods A total of 20 male-Wistar rats were distributed into four groups (n=5): Control group: animals received an intraperitoneal (i.p.) injection of 0.9% saline solution and after 15 days, 1 mL of water was administered for 15 days, via gavage; Cadmium group: animals received an intraperitoneal injection of cadmium chloride (1.2 mg/kg) and after 15 days, 1 mL of water was administered for 15 days via gavage; Cadmium+Grape Juice: animals received an i.p. injection of cadmium chloride (1.2 mg/kg), and after 15 days, 0.8 mL of grape juice was administered for 15 days, via gavage; Cadmium+Apple Juice: animals received i.p. injection of cadmium chloride (1.2 mg/kg) and after 15 days, 1.0 mL of apple juice was administered for 15 days, via gavage. Results Histopathological analysis revealed severe tubular lesion and necrosis in the group exposed to cadmium, while animals exposed to grape or apple juices showed a significant reduction of tissue injury. 8-OHdG immunoexpression, DNA damage, cytochrome C and catalase gene expressions and Toll like signaling pathway (TLR2, and pIKKα/β) decreased in animals treated with grape juice when compared to cadmium group. Conclusion Taken together, we conclude that grape and apple juices had a protective effect by means of antioxidant, antigenotoxic actions and for promoting tissue regeneration in the kidney of rats following cadmium intoxication.

506 Protective effect of IP administered olive oil in acute cadmium intoxication

2003 ◽  
Vol 144 ◽  
pp. s136
Author(s):  
V. Eybl ◽  
D. Kotyzova ◽  
J. Koutensky
Keyword(s):  
Protective Effect ◽  
Olive Oil ◽  
Cadmium Intoxication

scholarly journals Crown Procyanidin Tetramer: A Procyanidin with an Unusual Cyclic Skeleton with a Potent Protective Effect against Amyloid-β-Induced Toxicity

Molecules ◽  
2019 ◽  
Vol 24 (10) ◽  
pp. 1915 ◽  
Author(s):  
Liming Zeng ◽  
Pere Pons-Mercadé ◽  
Tristan Richard ◽  
Stéphanie Krisa ◽  
Pierre-Louis Teissèdre ◽  
...  
Keyword(s):  
Protective Effect ◽  
Spectroscopic Analysis ◽  
Amyloid Β ◽  
Carbon Skeleton ◽  
Protective Effects ◽  
Grape Skin ◽  
Plant Kingdom ◽  
First Time ◽  
Macrocyclic Structure

The structure of a new procyanidin tetramer, which we call a crown procyanidin tetramer, with an unprecedented macrocyclic structure has been characterized for the first time. Its comprehensive spectroscopic analysis revealed that it is a symmetric procyanidin tetramer composed of four (−)-epicatechin sub-units linked alternatively via 4β→8 or 4β→6 B-type interflavanyl linkages to form the macrocyclic structure. This NMR-characterized carbon skeleton has never been reported before for procyanidins in grape or in wine, neither in the plant kingdom. Surprisingly, the crown procyanidin tetramer appeared to be specifically localized in grape skin, contrasting with the oligomeric and polymeric procyanidins present in seed, skin, and bunch stem. Moreover, this crown procyanidin tetramer showed promising protective effects against amyloid-β induced toxicity.

scholarly journals The modifying impact of melaxen on the genotoxic effects of chronic cadmium intoxication in rats

2020 ◽  
pp. 105-106
Author(s):  
Т.В. Чшиев
Keyword(s):  
Protective Effect ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Micronucleus Test ◽  
Expected Number ◽  
Genotoxic Effects ◽  
Rat Blood ◽  
Cadmium Intoxication ◽  
Chronic Cadmium Intoxication

С использованием микроядерного теста было показано протекторное влияние мелаксена (10 мг/кг) при хронической экспериментальной интоксикации кадмием (0,3 мг/кг) в крови крыс, p<0,001. Исследуемый лекарственный препарат продемонстрировал способность снижать ожидаемое число микроядер и полихроматофильных эритроцитов (ПХЭ), индуцированных кадмием при двухнедельной и месячной экспозиции. При хроническом внутрижелудочном введении мелаксена не зафиксирован рост числа микроядер и ПХЭ по сравнению с контролем, p>0,05. Using the micronucleus test, the protective effect of melaxen (10 mg / kg) was shown in chronic experimental cadmium intoxication (0.3 mg / kg) in rat blood, p <0.001. The studied remedy demonstrated the ability to reduce the expected number of micronuclei and polychromatophilic red blood cells (PCE) induced by cadmium during two-week and one-month exposure. In chronic intragastric injection of melaxen, an increase in the number of micronuclei and PCEs was not registered in comparison with the control, p> 0.05.

Protective effect of chitooligosaccharides on hydrogen peroxide-induced PC-12 cells death by inhibition of oxidative damage

2010 ◽  
Vol 34 (8) ◽  
pp. S27-S27
Author(s):  
Xueling Dai ◽  
Ping Chang ◽  
Ke Xu ◽  
Changjun Lin ◽  
Hanchang Huang ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Oxidative Damage ◽  
Protective Effect ◽  
Pc 12 Cells ◽  
Cells Death

Protective effect of Trypanosoma rangeli against infections with a highly virulent strain of Trypanosoma cruzi

1997 ◽  
Vol 2 (5) ◽  
pp. 482-487 ◽  
Author(s):  
Claudio Zuniga ◽  
Teresa Palau ◽  
Pilar Penin ◽  
Carlos Gamallo ◽  
Jose Antonio de Diego
Keyword(s):  
Trypanosoma Cruzi ◽  
Protective Effect ◽  
Virulent Strain ◽  
Trypanosoma Rangeli ◽  
Highly Virulent

The Relationship Between Antioxidant Nutrient Intake and Cataracts in Older People

2006 ◽  
Vol 76 (6) ◽  
pp. 359-366 ◽  
Author(s):  
Rodríguez-Rodríguez ◽  
Ortega ◽  
López-Sobaler ◽  
Aparicio ◽  
Bermejo ◽  
...  
Keyword(s):  
Vitamin C ◽  
Older People ◽  
Dietary Intake ◽  
Protective Effect ◽  
Elderly People ◽  
Nutrient Intake ◽  
Institutionalized Elderly ◽  
Weighing Method ◽  
The Relationship

This study investigated the relationship between the intake of antioxidant nutrients and the suffering of cataracts in 177 institutionalized elderly people (61 men and 116 women) aged ≥ 65 years. Dietary intake was monitored for 7 consecutive days using a "precise individual weighing" method. Subjects, who during their earlier years were exposed by their work to sunlight, had a greater risk of suffering cataracts (OR = 3.2; Cl: 1.1–9.3, P < 0.05) than those who worked indoors. A relationship was found between increased vitamin C intake and a reduced prevalence of cataracts (i.e., when comparing those above P95 for vitamin C intake with those below P5; (OR = 0.08; Cl: 0.01–0.75, P 0.05). Among subjects with cataracts, 12.1% had vitamin C intakes of < 61 mg/day (P10) and only 2.2% had intakes of > 183 mg/day (P95) (p < 0.01). Subjects who consumed > 3290 μg/day (P95) of lutein were less likely to have cataracts (OR = 0.086; Cl: 0.007–1.084; p < 0.05) than those whose consumption was < 256 μg/day (P5). In men, high intakes of zeaxanthin seemed to provide a protective effect against the problem (OR = 0.96; Cl: 0.91–0.99; p < 0.05). The results suggest an association exists between exposure to sunlight and the development of cataracts, and that vitamin C, lutein, and zeaxanthin offer some protection against this disorder.

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