Protective effect of chitooligosaccharides on hydrogen peroxide-induced PC-12 cells death by inhibition of oxidative damage

2010 ◽  
Vol 34 (8) ◽  
pp. S27-S27
Author(s):  
Xueling Dai ◽  
Ping Chang ◽  
Ke Xu ◽  
Changjun Lin ◽  
Hanchang Huang ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Oxidative Damage ◽  
Protective Effect ◽  
Pc 12 Cells ◽  
Cells Death

scholarly journals Protective Effect of Quercetin against H2O2-Induced Oxidative Damage in PC-12 Cells: Comprehensive Analysis of a lncRNA-Associated ceRNA Network

2020 ◽  
Vol 2020 ◽  
pp. 1-22
Author(s):  
Zheyu Zhang ◽  
Pengji Yi ◽  
Min Yi ◽  
Xiaoliang Tong ◽  
Xin Cheng ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Oxidative Damage ◽  
Protective Effect ◽  
Messenger Rna ◽  
Noncoding Rna ◽  
Expression Profiles ◽  
Damage Model ◽  
Antioxidant Properties ◽  
Pc 12 Cells ◽  
Cerna Network

Quercetin is a bioflavonoid with potential antioxidant properties. However, the mechanisms underlying its effects remain unclear. Herein, we focused on integrating long noncoding RNA (lncRNA), microRNA (miRNA), and messenger RNA (mRNA) sequencing of PC-12 cells treated with quercetin. We treated PC-12 cells with hydrogen peroxide to generate a validated oxidative damage model. We evaluated the effects of quercetin on PC-12 cells and established the lncRNA, miRNA, and mRNA profiles of these cells. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses of these RNAs were conducted to identify the key pathways. Quercetin significantly protected PC-12 neuronal cells from hydrogen peroxide-induced death. We identified 297, 194, and 14 significantly dysregulated lncRNAs, miRNAs, and mRNAs, respectively, associated with the antioxidant effect of quercetin. Furthermore, the phosphatidylinositol-3-kinase/protein kinase B pathway was identified as the crucial signalling pathway. Finally, we constructed a lncRNA-associated competing endogenous RNA (ceRNA) network by utilizing oxidative damage mechanism-matched miRNA, lncRNA, and mRNA expression profiles and those changed by quercetin. In conclusion, quercetin exerted a protective effect against oxidative stress-induced damage in PC-12 cells. Our study provides novel insight into ceRNA-mediated gene regulation in the progression of oxidative damage and the action mechanisms of quercetin.

Protective effect of cholesterol-loaded cyclodextrin pretreatment against hydrogen peroxide induced oxidative damage in ram sperm

Cryobiology ◽  
2015 ◽  
Vol 71 (1) ◽  
pp. 18-23 ◽  
Author(s):  
Zahid Naseer ◽  
Ejaz Ahmad ◽  
Melih Aksoy ◽  
Niyazi Küçük ◽  
İlker Serin ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Oxidative Damage ◽  
Protective Effect ◽  
Ram Sperm

Protective effect of areca inflorescence extract on hydrogen peroxide-induced oxidative damage to human serum albumin

2011 ◽  
Vol 44 (1) ◽  
pp. 98-102 ◽  
Author(s):  
Fangfang Cheng ◽  
Weijun Chen ◽  
Yulin Huang ◽  
Chunmei Zhang ◽  
Yan Shen ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Human Serum Albumin ◽  
Oxidative Damage ◽  
Serum Albumin ◽  
Protective Effect ◽  
Human Serum
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