Nucleotide-binding oligomerization domain protein 2 (NOD2/CARD15) mutation p.R702W predisposes to a fatal outcome of severe acute pancreatitis

Pancreatology ◽  
2013 ◽  
Vol 13 (3) ◽  
pp. S7-S8
Author(s):  
Annett Guenther ◽  
Rian M. Nijmeijer ◽  
Claudia Nitsche ◽  
Ali Aghdassi ◽  
Marja A. Boemeester ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Severe Acute Pancreatitis ◽  
Fatal Outcome ◽  
Nucleotide Binding ◽  
Domain Protein ◽  
Card15 Mutation ◽  
Oligomerization Domain

scholarly journals Nucleotide‐binding oligomerization domain protein 2 deficiency enhances CHOP expression and plaque necrosis in advanced atherosclerotic lesions

FEBS Journal ◽  
2020 ◽  
Vol 287 (10) ◽  
pp. 2055-2069
Author(s):  
Min‐Young Kwon ◽  
Narae Hwang ◽  
Sung Hoon Back ◽  
Seon‐Jin Lee ◽  
Mark A. Perrella ◽  
...  
Keyword(s):  
Nucleotide Binding ◽  
Chop Expression ◽  
Atherosclerotic Lesions ◽  
Domain Protein ◽  
Oligomerization Domain

scholarly journals Monitoring Approach of Fatality Risk Factors for Patients with Severe Acute Pancreatitis Admitted to the Intensive Care Unit. A Retrospective, Monocentric Study

Diagnostics ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 2013
Author(s):  
Tudorel Mihoc ◽  
Cristi Tarta ◽  
Ciprian Duta ◽  
Raluca Lupusoru ◽  
Greta Dancu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intensive Care Unit ◽  
Acute Pancreatitis ◽  
Intensive Care ◽  
Severe Acute Pancreatitis ◽  
Fatal Outcome ◽  
Factors Associated ◽  
Reactive Protein ◽  
Wide Range ◽  
Secondary Objective

Acute pancreatitis is an unpredictable disease affecting the pancreas and it is characterized by a wide range of symptoms and modified lab tests, thus there is a continuing struggle to classify this disease and to find risk factors associated with a worse outcome. The main objective of this study was to identify the risk factors associated with the fatal outcome of the intensive care unit’s patients diagnosed and admitted for severe acute pancreatitis, the secondary objective was to investigate the prediction value for the death of different inflammatory markers at the time of their admission to the hospital. This retrospective study included all the patients with a diagnosis of acute pancreatitis admitted to the Intensive Care Unit of the Emergency County Hospital Timisoara between 1 January 2016 and 31 May 2021. The study included 53 patients diagnosed with severe acute pancreatitis, out of which 21 (39.6%) survived and 32 (60.4%) died. For the neutrophils/lymphocytes ratio, a cut-off value of 12.4 was found. When analyzing age, we found out that age above 52 years old can predict mortality, and for the platelets/lymphocytes ratio, a cut-off value of 127 was found. Combining the three factors we get a new model for predicting mortality, with an increased performance, AUROC = 0.95, p < 0.001. Multiple persistent organ failure, age over 50, higher values of C reactive protein, and surgery were risk factors for death in the patients with severe acute pancreatitis admitted to the intensive care unit. The model design from the neutrophils/lymphocytes ratio, platelets/lymphocytes ratio, and age proved to be the best in predicting mortality in severe acute pancreatitis.

Predicting fatal outcome in early phase of severe acute pancreatitis

2000 ◽  
Vol 118 (4) ◽  
pp. A421 ◽  
Author(s):  
Kimmo I. Halonen ◽  
Ari K. Leppaniemi ◽  
Johan E. Lundin ◽  
Pauli A. Puolakkainen ◽  
Esko A. Kemppainen ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Severe Acute Pancreatitis ◽  
Early Phase ◽  
Fatal Outcome

Predicting fatal outcome in the early phase of severe acute pancreatitis by using novel prognostic models

Pancreatology ◽  
2003 ◽  
Vol 3 (4) ◽  
pp. 309-315 ◽  
Author(s):  
Kimmo I. Halonen ◽  
Ari K. Leppäniemi ◽  
Johan E. Lundin ◽  
Pauli A. Puolakkainen ◽  
Esko A. Kemppainen ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Severe Acute Pancreatitis ◽  
Early Phase ◽  
Fatal Outcome ◽  
Prognostic Models
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