Predicting fatal outcome in the early phase of severe acute pancreatitis by using novel prognostic models

Pancreatology ◽  
2003 ◽  
Vol 3 (4) ◽  
pp. 309-315 ◽  
Author(s):  
Kimmo I. Halonen ◽  
Ari K. Leppäniemi ◽  
Johan E. Lundin ◽  
Pauli A. Puolakkainen ◽  
Esko A. Kemppainen ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Severe Acute Pancreatitis ◽  
Early Phase ◽  
Fatal Outcome ◽  
Prognostic Models

Predicting fatal outcome in early phase of severe acute pancreatitis

2000 ◽  
Vol 118 (4) ◽  
pp. A421 ◽  
Author(s):  
Kimmo I. Halonen ◽  
Ari K. Leppaniemi ◽  
Johan E. Lundin ◽  
Pauli A. Puolakkainen ◽  
Esko A. Kemppainen ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Severe Acute Pancreatitis ◽  
Early Phase ◽  
Fatal Outcome

scholarly journals Monitoring Approach of Fatality Risk Factors for Patients with Severe Acute Pancreatitis Admitted to the Intensive Care Unit. A Retrospective, Monocentric Study

Diagnostics ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 2013
Author(s):  
Tudorel Mihoc ◽  
Cristi Tarta ◽  
Ciprian Duta ◽  
Raluca Lupusoru ◽  
Greta Dancu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intensive Care Unit ◽  
Acute Pancreatitis ◽  
Intensive Care ◽  
Severe Acute Pancreatitis ◽  
Fatal Outcome ◽  
Factors Associated ◽  
Reactive Protein ◽  
Wide Range ◽  
Secondary Objective

Acute pancreatitis is an unpredictable disease affecting the pancreas and it is characterized by a wide range of symptoms and modified lab tests, thus there is a continuing struggle to classify this disease and to find risk factors associated with a worse outcome. The main objective of this study was to identify the risk factors associated with the fatal outcome of the intensive care unit’s patients diagnosed and admitted for severe acute pancreatitis, the secondary objective was to investigate the prediction value for the death of different inflammatory markers at the time of their admission to the hospital. This retrospective study included all the patients with a diagnosis of acute pancreatitis admitted to the Intensive Care Unit of the Emergency County Hospital Timisoara between 1 January 2016 and 31 May 2021. The study included 53 patients diagnosed with severe acute pancreatitis, out of which 21 (39.6%) survived and 32 (60.4%) died. For the neutrophils/lymphocytes ratio, a cut-off value of 12.4 was found. When analyzing age, we found out that age above 52 years old can predict mortality, and for the platelets/lymphocytes ratio, a cut-off value of 127 was found. Combining the three factors we get a new model for predicting mortality, with an increased performance, AUROC = 0.95, p < 0.001. Multiple persistent organ failure, age over 50, higher values of C reactive protein, and surgery were risk factors for death in the patients with severe acute pancreatitis admitted to the intensive care unit. The model design from the neutrophils/lymphocytes ratio, platelets/lymphocytes ratio, and age proved to be the best in predicting mortality in severe acute pancreatitis.

Nucleotide-binding oligomerization domain protein 2 (NOD2/CARD15) mutation p.R702W predisposes to a fatal outcome of severe acute pancreatitis

Pancreatology ◽  
2013 ◽  
Vol 13 (3) ◽  
pp. S7-S8
Author(s):  
Annett Guenther ◽  
Rian M. Nijmeijer ◽  
Claudia Nitsche ◽  
Ali Aghdassi ◽  
Marja A. Boemeester ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Severe Acute Pancreatitis ◽  
Fatal Outcome ◽  
Nucleotide Binding ◽  
Domain Protein ◽  
Card15 Mutation ◽  
Oligomerization Domain

The protective effects of Lipoxin A4during the early phase of severe acute pancreatitis in rats

2010 ◽  
Vol 46 (2) ◽  
pp. 211-219 ◽  
Author(s):  
Mengtao Zhou ◽  
Bicheng Chen ◽  
Hongwei Sun ◽  
Zhexian Deng ◽  
Roland Andersson ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Severe Acute Pancreatitis ◽  
Early Phase ◽  
Protective Effects

Early-phase peritoneal drainage and lavage in a rat model of severe acute pancreatitis

Surgery Today ◽  
2015 ◽  
Vol 46 (3) ◽  
pp. 371-378 ◽  
Author(s):  
Leiming Zhu ◽  
Jilin Lu ◽  
Jing Yang ◽  
Peng Sun
Keyword(s):  
Acute Pancreatitis ◽  
Severe Acute Pancreatitis ◽  
Rat Model ◽  
Early Phase ◽  
Peritoneal Drainage

scholarly journals Efficiency of prognostic scales in assessing patients' condition in severe acute pancreatitis

2020 ◽  
Vol 5 (4) ◽  
pp. 278-282
Author(s):  
I. V. Makarov ◽  
I. A. Mustafaev ◽  
A. V. Kurashev ◽  
L. A. Budorina ◽  
L. V. Gerasimov
Keyword(s):  
Acute Pancreatitis ◽  
Mortality Rate ◽  
Severe Acute Pancreatitis ◽  
Fatal Outcome ◽  
Apache Ii ◽  
Surgical Department ◽  
Icu Admission ◽  
Group 2 ◽  
Admission Group ◽  
Group 1

Objectives to compare the predictive efficiency of modern scales used in prognosis of disease severity (APACHE II, SAPS, SOFA, MODS) in patients with severe acute pancreatitis. Material and methods.17 patients formed two study groups: Group 1 consisted of 10 survived patients, Group 2 included 7 patients with a fatal outcome. The mortality ratio and the severity of the condition were calculated for all 17 patients, using the scales presented above, at the admission to the ICU and at the moment of transfer to a surgical department. The intensive care procedure and surgical interventions were in line with the clinical recommendations for surgical treatment of severe acute pancreatitis. Results.The day of ICU admission, Group 1, the average mortality rate on the SAPS scale was 110.08%; on the SOFA scale 270.08%; on the MODS scale 12%; on the APACHE II scale 8.450.09%. The day of ICU admission, Group 2, the average mortality rate on the SAPS scale was 5.77.11%; on the SOFA scale 25.146.09%; on the MODS scale 2.41.05%; on the APACHE II scale 12.18.49%. The day of patients' transfer from the ICU to the surgical department, Group1, the average mortality rate on the SAPS scale was 8.990.10%; on the SOFA scale 300.15%; on the MODS scale 12%; on the APACHE II scale 14.290.08%. The day of patients' transfer from the ICU to the surgical department, Group 2, the average mortality rate on the SAPS scale was 7.78.69%; on the SOFA scale 220%; on the MODS scale 12%, on the APACHE II scale 12.379.89%. According to our data, none of the used prognostic scales could present the real condition of a patient or the mortality prognosis for patients in both groups. By comparison of the average mortality rate calculated for patients of Group 1 and Group 2, we revealed the more unfavorable prognosis for the survived patients than for the patients with lethal outcome. Conclusion.The objective evaluation of the severity of patient's condition and the prognosis for treatment is not possible with the scales used in the study. Among them, the SAPS and APACHE II scales provided the most precise prognoses for patients' condition.

scholarly journals Usefulness of Early-phase Peritoneal Lavage for Treating Severe Acute Pancreatitis

2014 ◽  
Vol 53 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Kazuyuki Matsumoto ◽  
Yasuhiro Miyake ◽  
Morihito Nakatsu ◽  
Tatsuya Toyokawa ◽  
Masaharu Ando ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Severe Acute Pancreatitis ◽  
Early Phase ◽  
Peritoneal Lavage

scholarly journals Inhibition of nuclear factor-κB activation improves the survival of rats with taurocholate pancreatitis

Gut ◽  
1999 ◽  
Vol 44 (2) ◽  
pp. 253-258 ◽  
Author(s):  
A Satoh ◽  
T Shimosegawa ◽  
M Fujita ◽  
K Kimura ◽  
A Masamune ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Severe Acute Pancreatitis ◽  
Alveolar Macrophages ◽  
Fatal Outcome ◽  
Nuclear Factor Κb ◽  
Multiple Organ ◽  
Pyrrolidine Dithiocarbamate ◽  
Nuclear Factor ◽  
Taurocholate Pancreatitis ◽  
Severity Of The Disease

BackgroundDeath in the early stages of severe acute pancreatitis is frequently the result of multiple organ dysfunction, but its mechanism is not clear.AimsTo investigate the state of nuclear factor-κB (NF-κB) in macrophages of rats with lethal pancreatitis, and to assess the effectiveness of pyrrolidine dithiocarbamate, an inhibitor of NF-κB, on the pathology and mortality.MethodsTaurocholate pancreatitis was produced in rats, and the severity of the disease, the mortality, and activation of NF-κB in peritoneal and alveolar macrophages were compared in rats receiving pyrrolidine dithiocarbamate (PDTC) treatment and those that were not.ResultsTaurocholate pancreatitis produced massive necrosis, haemorrhage, and severe leucocyte infiltration in the pancreas as well as alveolar septal thickening in the lung. NF-κB was activated in peritoneal and alveolar macrophages six hours after pancreatitis induction. Pretreatment with PDTC dose-dependently attenuated the NF-κB activation and improved the survival of the rats, although it did not affect the early increase in serum amylase and histological findings.ConclusionsEarly blockage of NF-κB activation may be effective in reducing fatal outcome in severe acute pancreatitis.

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