scholarly journals Fish oil attenuates liver injury caused by LPS in weaned pigs associated with inhibition of TLR4 and nucleotide-binding oligomerization domain protein signaling pathways

2013 ◽  
Vol 19 (5) ◽  
pp. 504-515 ◽  
Author(s):  
Feng Chen ◽  
Yulan Liu ◽  
Huiling Zhu ◽  
Yu Hong ◽  
Zhifeng Wu ◽  
...  
Keyword(s):  
Liver Injury ◽  
Fish Oil ◽  
Signaling Pathways ◽  
Nucleotide Binding ◽  
Protein Signaling ◽  
Weaned Pigs ◽  
Domain Protein ◽  
Oligomerization Domain

scholarly journals Nucleotide‐binding oligomerization domain protein 2 deficiency enhances CHOP expression and plaque necrosis in advanced atherosclerotic lesions

FEBS Journal ◽  
2020 ◽  
Vol 287 (10) ◽  
pp. 2055-2069
Author(s):  
Min‐Young Kwon ◽  
Narae Hwang ◽  
Sung Hoon Back ◽  
Seon‐Jin Lee ◽  
Mark A. Perrella ◽  
...  
Keyword(s):  
Nucleotide Binding ◽  
Chop Expression ◽  
Atherosclerotic Lesions ◽  
Domain Protein ◽  
Oligomerization Domain

Nucleotide-binding oligomerization domain protein 2 (NOD2/CARD15) mutation p.R702W predisposes to a fatal outcome of severe acute pancreatitis

Pancreatology ◽  
2013 ◽  
Vol 13 (3) ◽  
pp. S7-S8
Author(s):  
Annett Guenther ◽  
Rian M. Nijmeijer ◽  
Claudia Nitsche ◽  
Ali Aghdassi ◽  
Marja A. Boemeester ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Severe Acute Pancreatitis ◽  
Fatal Outcome ◽  
Nucleotide Binding ◽  
Domain Protein ◽  
Card15 Mutation ◽  
Oligomerization Domain

Neutrophil Migration During Liver Injury Is Under Nucleotide-Binding Oligomerization Domain 1 Control

2010 ◽  
Vol 138 (4) ◽  
pp. 1546-1556.e5 ◽  
Author(s):  
Sébastien Dharancy ◽  
Mathilde Body–Malapel ◽  
Alexandre Louvet ◽  
Dominique Berrebi ◽  
Emilie Gantier ◽  
...  
Keyword(s):  
Liver Injury ◽  
Neutrophil Migration ◽  
Nucleotide Binding ◽  
Oligomerization Domain

scholarly journals Nucleotide-Binding Oligomerization Domain Protein 2 Deficiency Enhances Neointimal Formation in Response to Vascular Injury

2011 ◽  
Vol 31 (11) ◽  
pp. 2441-2447 ◽  
Author(s):  
Min-Young Kwon ◽  
Xiaoli Liu ◽  
Seon-Jin Lee ◽  
Young-Ho Kang ◽  
Augustine M.K. Choi ◽  
...  
Keyword(s):  
Vascular Injury ◽  
Nucleotide Binding ◽  
Neointimal Formation ◽  
Domain Protein ◽  
Oligomerization Domain

scholarly journals Fish Oil Enhances Intestinal Integrity and Inhibits TLR4 and NOD2 Signaling Pathways in Weaned Pigs after LPS Challenge

2012 ◽  
Vol 142 (11) ◽  
pp. 2017-2024 ◽  
Author(s):  
Yulan Liu ◽  
Feng Chen ◽  
Jack Odle ◽  
Xi Lin ◽  
Sheila K. Jacobi ◽  
...  
Keyword(s):  
Fish Oil ◽  
Signaling Pathways ◽  
Weaned Pigs ◽  
Intestinal Integrity ◽  
Lps Challenge

scholarly journals CARD6 Is Interferon Inducible but Not Involved in Nucleotide-Binding Oligomerization Domain Protein Signaling Leading to NF-κB Activation

2007 ◽  
Vol 28 (5) ◽  
pp. 1541-1552 ◽  
Author(s):  
Almut Dufner ◽  
Gordon S. Duncan ◽  
Andrew Wakeham ◽  
Alisha R. Elford ◽  
Håkan T. Hall ◽  
...  
Keyword(s):  
Nucleotide Binding ◽  
Adenovirus Type ◽  
Lymphocytic Choriomeningitis ◽  
Immune Defense ◽  
Protein Signaling ◽  
Interacting Protein ◽  
Serovar Typhimurium ◽  
Bacterial Peptidoglycan ◽  
Oligomerization Domain

ABSTRACT We have previously reported the cloning and characterization of CARD6, a caspase recruitment domain (CARD)-containing protein that is structurally related to the interferon (IFN)-inducible GTPases. CARD6 associates with microtubules and with receptor-interacting protein 2 (RIP2). RIP2 mediates NF-κB activation induced by the intracellular nucleotide-binding oligomerization domain (NOD) receptors that sense bacterial peptidoglycan. Here we report that the expression of CARD6 and RIP2 in bone marrow-derived macrophages is rapidly induced by beta IFN and gamma IFN. This IFN-induced upregulation of CARD6 is suppressed by lipopolysaccharide (LPS), in contrast to LPS's enhancement of IFN-induced RIP2 upregulation. We generated CARD6-deficient (CARD6−/−) mice and carried out extensive analyses of signaling pathways mediating innate and adaptive immune responses, including the NOD pathways, but did not detect any abnormalities. Moreover, CARD6−/− mice were just as susceptible as wild-type mice to infection by Salmonella enterica serovar Typhimurium, Listeria monocytogenes, Candida albicans, lymphocytic choriomeningitis virus, or mouse adenovirus type 1. Thus, although structural and in vitro analyses strongly suggest an important role for CARD6 in immune defense, the physiological function of CARD6 remains obscure.

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