ALTERATIONS IN THE BMAL1 CLOCK GENE DELAY WOUND HEALING: AN ANIMAL MODEL EXPERIMENTAL STUDY

2020 ◽  
Vol 130 (3) ◽  
pp. e251
Author(s):  
ÉRICKA JANINE DANTAS DA SILVEIRA ◽  
CARLOS VIESI DO NASCIMMENTO FILHO ◽  
VERôNICA QUISPE YUJRA ◽  
ROGéRIO MORAES DE CASTILHO ◽  
CRISTIANE HELENA SQUARIZE
Keyword(s):  
Experimental Study ◽  
Wound Healing ◽  
Animal Model ◽  
Clock Gene

scholarly journals Topical Application of Ozonated Oils for the Treatment of MRSA Skin Infection in an Animal Model of Infected Ulcer

Biology ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 372
Author(s):  
Vanessa Silva ◽  
Cecília Peirone ◽  
Rosa Capita ◽  
Carlos Alonso-Calleja ◽  
José A Marques-Magallanes ◽  
...  
Keyword(s):  
Wound Healing ◽  
Animal Model ◽  
Topical Application ◽  
Early Stage ◽  
Bacterial Load ◽  
Ozone Treatment ◽  
Diabetic Patients ◽  
Colony Forming Units ◽  
Group 2 ◽  
Epidermal Regeneration

Diabetic foot ulcers are a common cause of morbidity in diabetic patients. One of the main pathogens found in these ulcers is methicillin-resistant Staphylococcus aureus (MRSA). MRSA often carries resistance to several classes of antibiotics and their infections are becoming harder to treat. Therefore, new alternatives are urgently needed. Thus, this study aimed to investigate the capacity of topical ozonated oil application on the treatment of early-stage skin infected with MRSA in an animal model. Ozonated oil was prepared from a mixture of oils subjected to a gas stream of O2/O3 mixture. Sixteen Wistar rats were inoculated by an intradermic injection of MRSA suspension, producing an abscess lesion. After 3 days, the skin epidermis was removed to open the wound. Group 1 received an application of oil mixture without ozone treatment and Group 2 received an application of ozonated oil. After the treatment period, skin was collected, colony-forming units (CFU) of bacteria were quantified and the histological analysis of the skin was carried out. Skin samples from the control 1 and 2 had a bacterial load was of 1.1 × 105 and 5.7 × 103 CFU/mL, respectively. Group 2 showed better wound healing from mild to moderate epidermal regeneration. Topical application of ozonated vegetable oil in MRSA-infected skin in rats showed a small reduction of the bacterial load and better wound healing.

An in vivo Investigation on the Wound-Healing Effect of Two Medicinal Herbs Using an Animal Model with Foot Ulcer

2008 ◽  
Vol 41 (1) ◽  
pp. 15-23 ◽  
Author(s):  
T.W. Lau ◽  
D.S. Sahota ◽  
C.H. Lau ◽  
C.M. Chan ◽  
F.C. Lam ◽  
...  
Keyword(s):  
Wound Healing ◽  
Animal Model ◽  
Foot Ulcer ◽  
Medicinal Herbs ◽  
Healing Effect ◽  
Wound Healing Effect

scholarly journals Effect of topically applied sildenafil citrate on wound healing: experimental study

2014 ◽  
Vol 14 (3) ◽  
pp. 125 ◽  
Author(s):  
Koray Gürsoy ◽  
Melike Oruç ◽  
Yüksel Kankaya ◽  
Mustafa Gürhan Ulusoy ◽  
Uğur Koçer ◽  
...  
Keyword(s):  
Experimental Study ◽  
Wound Healing ◽  
Sildenafil Citrate

Evaluation of effectiveness of a new treatment method for healing infected wounds: an animal model

2021 ◽  
Vol 30 (4) ◽  
pp. 312-322
Author(s):  
Alexandr A Basov ◽  
Sergey R Fedosov ◽  
Vadim V Malyshko ◽  
Anna A Elkina ◽  
Oxana M Lyasota ◽  
...  
Keyword(s):  
Wound Healing ◽  
Animal Model ◽  
Active Agent ◽  
Treatment Method ◽  
Healing Time ◽  
Male Adult ◽  
New Device ◽  
Infected Wounds ◽  
New Treatment ◽  
Wound Healing Time

Objective: To evaluate the effectiveness of a new treatment method in healing superficial infected wounds compared with surgical debridement with chlorhexidine solution. Method: In this animal model, two wounds were created on the back of 10 male adult rabbits. Wounds treated by Method 1 were debrided using 0.02% chlorhexidine aqueous solution and an antibiotic topical ointment. Wounds treated by Method 2 wounds were treated using a newly developed device which enabled visual monitoring of the wound as it was treated with various pharmacological solutions (including antiseptic, antiseptic oxidant and an osmotically active agent) specifically formulated for each wound healing stage. Wound area size (using digital planimetry) and time taken to clean the wound were recorded, and biopsies were taken, at the beginning of the study and at various timepoints throughout. Result: It was observed that both wound cleaning and wound healing were accelerated by treatment with method 2 compared with method 1 (by 43.8% and 36.7%, respectively). There were also a significantly smaller number of complications in these wounds [p=0.0044] due to the positive ratios of neutrophils and fibroblasts in the wound cavities (from the third to the fourteenth day after wound modelling). Conclusion: Wounds treated with the new device in method 2 had a shorter wound healing time than wounds treated with a traditional method. The automated influx–outflow of solutions removed any fragments of necrotic tissue from the wound surface. Wounds were able to be monitored without the need to remove dressings. The transparent, airtight film, which allowed for wound monitoring without the need to remove dressings, meant that suturing was not required. This resulted in no complications in the wounds treated by this new method.

scholarly journals Effects of Chitosan/Nano Selenium Biofilm on Infected Wound Healing in Rats; An Experimental Study

2019 ◽  
Vol 7 (3) ◽  
pp. 284-291
Author(s):  
Abolfazl Abbaszadeh ◽  
Akram Tehmasebi-Foolad ◽  
Asghar Rajabzadeh ◽  
Nasim Beigi-Brojeni ◽  
Leila Zarei
Keyword(s):  
Experimental Study ◽  
Wound Healing ◽  
Infected Wound
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