An in vivo Investigation on the Wound-Healing Effect of Two Medicinal Herbs Using an Animal Model with Foot Ulcer

2008 ◽  
Vol 41 (1) ◽  
pp. 15-23 ◽  
Author(s):  
T.W. Lau ◽  
D.S. Sahota ◽  
C.H. Lau ◽  
C.M. Chan ◽  
F.C. Lam ◽  
...  
Keyword(s):  
Wound Healing ◽  
Animal Model ◽  
Foot Ulcer ◽  
Medicinal Herbs ◽  
Healing Effect ◽  
Wound Healing Effect

scholarly journals Creation of Polymer Hydrogel Dressings with Herbal Medicinal Substance "Alkhydin" and their Properties

2017 ◽  
Vol 19 (1) ◽  
pp. 57
Author(s):  
G. Temirkhanova ◽  
G. Burasheva ◽  
Zh. Abilov ◽  
G. Irmukhametova ◽  
A. Mun ◽  
...  
Keyword(s):  
Wound Healing ◽  
Polymer Network ◽  
Dimensional Structure ◽  
Initial Reaction ◽  
Medicinal Substance ◽  
Burn Wound ◽  
Healing Effect ◽  
Wound Healing Effect ◽  
Herbal Medicinal

New hydrogel dressings containing the herbal medicinal substance "Alkhydin", obtained from the Kirghiz (Alhagi kirghisorum Schrenk), grown in Kazakhstan, were obtained by radiation irradiation of the initial reaction mixture (IRM). Poly-<br />N-vinylpyrrolidone (PVP) with a molecular weight (MM) of 1 ppm was used to prepare hydrogel dressings as the main gelling polymer for IRM, agar-agar and lowmolecular polyethylene glycol MM = 600 were used as auxiliary substances. The main regularities of the formation of the three-dimensional structure of PVP under conditions of irradiation of IRM are investigated. It is shown that with increasing PVP in IRM, as well as irradiation dose, the yield of gel fraction increases and the degree of swelling decreases. Obviously, these effects are due to an increase in the degree of cross-linking of the polymer network formed. For the obtained hydrogel dressings containing the herbal medicinal substance Alkhydin, cytotoxic effects on the culture of mouse embryonic fibroblasts obtained by primary trypsinization were studied. The results obtained in this case testify to the absence of a cytotoxic effect on the cell culture. In conditions "in vivo" in rats using the model of thermal skin burn, the wound healing effect of hydrogel dressings with "Alkhydin" was studied. It is shown that such bandages show a pronounced wound-healing effect. This is evidenced by a higher rate of reduction in the area of the burn wound treated with a hydrogel dressing compared to the control.

scholarly journals Wound healing effect of regenerated oxidized cellulose versus fibrin sealant patch: An in vivo study

2019 ◽  
Vol 20 (5) ◽  
pp. 289-296 ◽  
Author(s):  
Hyun Sik Yoon ◽  
Young Cheon Na ◽  
Keum Ha Choi ◽  
Woo Hoe Huh ◽  
Ji Min Kim
Keyword(s):  
Wound Healing ◽  
Fibrin Sealant ◽  
In Vivo Study ◽  
Oxidized Cellulose ◽  
Healing Effect ◽  
Wound Healing Effect

scholarly journals In vitro antimicrobial and in vivo wound healing effect of actinobacterially synthesised nanoparticles of silver, gold and their alloy

RSC Advances ◽  
2017 ◽  
Vol 7 (81) ◽  
pp. 51729-51743 ◽  
Author(s):  
Thangavel Shanmugasundaram ◽  
Manikkam Radhakrishnan ◽  
Venugopal Gopikrishnan ◽  
Krishna Kadirvelu ◽  
Ramasamy Balagurunathan
Keyword(s):  
Wound Healing ◽  
Au Nanoparticles ◽  
Healing Effect ◽  
Wound Healing Effect ◽  
Nanoparticles Of Silver

Antibacterial, antifungal and wound healing potential of actinobacterially synthesised Ag, Au and Ag/Au nanoparticles.

scholarly journals Preparation and Evaluation of Atorvastatin-Loaded Nanoemulgel on Wound-Healing Efficacy

Pharmaceutics ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 609 ◽  
Author(s):  
Morsy ◽  
Abdel-Latif ◽  
Nair ◽  
Venugopala ◽  
Ahmed ◽  
...  
Keyword(s):  
Wound Healing ◽  
Ex Vivo ◽  
Skin Permeation ◽  
Healing Effect ◽  
Complex Processes ◽  
Wound Healing Effect ◽  
Histological Architecture ◽  
Gel Formulations

Tissue repair and wound healing are complex processes that involve inflammation, granulation, and remodeling of the tissue. The potential of various statins including atorvastatin (ATR) to improve the wound healing effect was established. The aim of this study was to formulate and evaluate the efficacy of topical application of ATR-based nanoemulgel on wound healing. The prepared formulations (ATR gel, ATR emulgel, and ATR nanoemulgel) were evaluated for their physical appearance, rheological behavior, in vitro drug release and ex vivo drug permeation. The in vivo wound healing effect was evaluated in wound-induced rats. The prepared ATR gel formulations showed good physical properties and were comparable. The release profiles of drugs from gel, emulgel, and nanoemulgel were distinct. Skin permeation potential of ATR was significantly (p < 0.05) enhanced when formulated into nanoemulgel. In vivo wound healing studies showed that ATR nanoemulgel exhibited the highest percent wound contraction. Histopathological assessment showed marked improvement in the skin histological architecture after 21 days of ATR nanoemulgel treatment. In conclusion, the data demonstrated here signify the prospective of ATR nanoemulgel as an innovative therapeutic approach in wound healing.

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