A comparative evaluation of the systemic and local alendronate treatment in synthetic bone graft: a histologic and histomorphometric study in a rat calvarial defect model

2012 ◽  
Vol 114 (5) ◽  
pp. S146-S152 ◽  
Author(s):  
Hulya Toker ◽  
Hakan Ozdemir ◽  
Hatice Ozer ◽  
Kaya Eren
Keyword(s):  
Bone Graft ◽  
Comparative Evaluation ◽  
Calvarial Defect ◽  
Defect Model ◽  
Synthetic Bone ◽  
Synthetic Bone Graft ◽  
Histomorphometric Study ◽  
Alendronate Treatment ◽  
Rat Calvarial Defect

Evaluation of biocompatibility of α-1,3 galactosyltransferase knockout pig bone graft in a rat calvarial defect model

2014 ◽  
Vol 15 (2) ◽  
pp. 86-91
Author(s):  
Se Eun Kim ◽  
Ga Hoi Choi ◽  
Kyung Mi Shim ◽  
Seok Hwa Choi ◽  
Sang-Myeong Lee ◽  
...  
Keyword(s):  
Bone Graft ◽  
Calvarial Defect ◽  
Defect Model ◽  
Rat Calvarial Defect

scholarly journals Dehydrothermally Cross-Linked Collagen Membrane with a Bone Graft Improves Bone Regeneration in a Rat Calvarial Defect Model

Materials ◽  
2017 ◽  
Vol 10 (8) ◽  
pp. 927 ◽  
Author(s):  
Yin-Zhe An ◽  
Young-Ku Heo ◽  
Jung-Seok Lee ◽  
Ui-Won Jung ◽  
Seong-Ho Choi
Keyword(s):  
Bone Graft ◽  
Bone Regeneration ◽  
Collagen Membrane ◽  
Calvarial Defect ◽  
Defect Model ◽  
Rat Calvarial Defect

scholarly journals Establishment and effects of allograft and synthetic bone graft substitute treatment of a critical size metaphyseal bone defect model in the sheep femur

Apmis ◽  
2019 ◽  
Vol 127 (2) ◽  
pp. 53-63 ◽  
Author(s):  
Werner Hettwer ◽  
Peter F. Horstmann ◽  
Sabine Bischoff ◽  
Daniel Güllmar ◽  
Jürgen R. Reichenbach ◽  
...  
Keyword(s):  
Bone Graft ◽  
Bone Defect ◽  
Critical Size ◽  
Bone Graft Substitute ◽  
Defect Model ◽  
Synthetic Bone ◽  
Synthetic Bone Graft ◽  
Metaphyseal Bone

Nanoparticulate Hydroxyapatite Enhances the Bioactivity of a Resorbable Bone Graft

2002 ◽  
Vol 735 ◽  
Author(s):  
Stephen A. Doherty ◽  
David D. Hile ◽  
Donald L. Wise ◽  
Jackie Y. Ying ◽  
Stephen T. Sonis ◽  
...  
Keyword(s):  
Bone Graft ◽  
Histological Analysis ◽  
Mechanical Stability ◽  
Unsaturated Polyester ◽  
Biological Response ◽  
Bone Graft Substitute ◽  
Calvarial Defect ◽  
Defect Model ◽  
Rat Calvarial Defect ◽  
Poly Propylene

ABSTRACTA nanoparticulate-hydroxyapatite filler augmented osteointegration within a resorbable polymer based bone graft substitute designed for orthopaedic and periodontal applications. The unsaturated polyester poly(propylene glycol-co-fumaric acid) (PPF), was used to prepare the bone graft substitute. The nanoparticulate-hydroxyapatite filler was examined in terms of biocompatibility, bony ingrowth and mechanical stability in a rat calvarial defect model. The nano-hydroxyapatite fillerwas compared against a commercially available micrometer-sized hydroxyapatite(HA) filler. Histological analysis indicated that remodeling of the newly formed bone was more advanced in the defect filled with the nano-hydroxyapatite augmented PPF. Mechanical evaluation showed a more rapid increase in stiffness of the nano-hydroxyapatite PPF. Implants of the nano-HA augmented PPF showed more advanced bone formation and recovery of mechanical properties, suggesting an improved biological response to the nano-sized particles.

scholarly journals 405 Radiological Analysis of Gentamicin Eluting Synthetic Bone Graft Substitute Used in The Management of Gustilo IIIB Open Fractures

2021 ◽  
Vol 108 (Supplement_2) ◽  
Author(s):  
A Aljawadi ◽  
I Madhi ◽  
T Naylor ◽  
M Elmajee ◽  
A Islam ◽  
...  
Keyword(s):  
Bone Graft ◽  
Cortical Thickness ◽  
Bone Graft Substitute ◽  
Fracture Site ◽  
Open Fractures ◽  
X Rays ◽  
Radiographic Images ◽  
Synthetic Bone ◽  
Synthetic Bone Graft

Abstract Background Management of traumatic bone void associated with Gustilo IIIB open fractures is challenging. Gentamicin eluting synthetic bone graft substitute (Cerament-G) had been recently utilised for the management of patients with these injuries. This study aims to assess radiological signs of Cerament-G remodelling. Method Retrospective data analysis of all patients admitted to our unit with IIIB open fractures who had Cerament-G applied as avoid filler. Postoperative radiographic images of the fracture site at 6-weeks, 3-months, 6-months and at the last follow-up were reviewed. The radiological signs of Cerament-G integration, percent of void healing, and bone cortical thickness at the final follow-up were assessed. Results 34 patients met our inclusion criteria, mean age: 42 years. Mean follow-up time was 20 months. 59% of patients had excellent (>90%) void filling, 26.4% of patients had 50-90% void filling, and 14.6% had < 50% void filling. Normal bone cortical thickness was restored on AP and Lateral views in 55.8% of patients. No residual Cerement-G was seen on X-rays at the final follow-up in any of the patients. Conclusions Our results showed successful integration of Cerament-G with excellent void filling and normal cortical thickness achieved in more than half of the patients.

scholarly journals Synthetic bone graft versus autograft or allograft for spinal fusion: a systematic review

2016 ◽  
Vol 25 (4) ◽  
pp. 509-516 ◽  
Author(s):  
Zorica Buser ◽  
Darrel S. Brodke ◽  
Jim A. Youssef ◽  
Hans-Joerg Meisel ◽  
Sue Lynn Myhre ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cohort Studies ◽  
Bone Graft ◽  
Spinal Fusion ◽  
Comparative Studies ◽  
Functional Outcomes ◽  
Retrospective Studies ◽  
Synthetic Bone ◽  
Synthetic Bone Graft ◽  
Bone Graft Substitutes

The purpose of this review was to compare the efficacy and safety of synthetic bone graft substitutes versus autograft or allograft for the treatment of lumbar and cervical spinal degenerative diseases. Multiple major medical reference databases were searched for studies that evaluated spinal fusion using synthetic bone graft substitutes (either alone or with an autograft or allograft) compared with autograft and allograft. Randomized controlled trials (RCT) and cohort studies with more than 10 patients were included. Radiographic fusion, patient-reported outcomes, and functional outcomes were the primary outcomes of interest. The search yielded 214 citations with 27 studies that met the inclusion criteria. For the patients with lumbar spinal degenerative disease, data from 19 comparative studies were included: 3 RCTs, 12 prospective, and 4 retrospective studies. Hydroxyapatite (HA), HA+collagen, β-tricalcium phosphate (β-TCP), calcium sulfate, or polymethylmethacrylate (PMMA) were used. Overall, there were no differences between the treatment groups in terms of fusion, functional outcomes, or complications, except in 1 study that found higher rates of HA graft absorption. For the patients with cervical degenerative conditions, data from 8 comparative studies were included: 4 RCTs and 4 cohort studies (1 prospective and 3 retrospective studies). Synthetic grafts included HA, β-TCP/HA, PMMA, and biocompatible osteoconductive polymer (BOP). The PMMA and BOP grafts led to lower fusion rates, and PMMA, HA, and BOP had greater risks of graft fragmentation, settling, and instrumentation problems compared with iliac crest bone graft. The overall quality of evidence evaluating the potential use and superiority of the synthetic biological materials for lumbar and cervical fusion in this systematic review was low or insufficient, largely due to the high potential for bias and small sample sizes. Thus, definitive conclusions or recommendations regarding the use of these synthetic materials should be made cautiously and within the context of the limitations of the evidence.

Comparison of SLA®or SLActive®implants placed in the maxillary sinus with or without synthetic bone graft materials - an animal study in sheep

2013 ◽  
Vol 25 (10) ◽  
pp. 1142-1148 ◽  
Author(s):  
Alexander Philipp ◽  
Warwick Duncan ◽  
Malgorzata Roos ◽  
Christoph H. Hämmerle ◽  
Thomas Attin ◽  
...  
Keyword(s):  
Bone Graft ◽  
Maxillary Sinus ◽  
Animal Study ◽  
Synthetic Bone ◽  
Synthetic Bone Graft
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