Nanoparticulate Hydroxyapatite Enhances the Bioactivity of a Resorbable Bone Graft

2002 ◽  
Vol 735 ◽  
Author(s):  
Stephen A. Doherty ◽  
David D. Hile ◽  
Donald L. Wise ◽  
Jackie Y. Ying ◽  
Stephen T. Sonis ◽  
...  
Keyword(s):  
Bone Graft ◽  
Histological Analysis ◽  
Mechanical Stability ◽  
Unsaturated Polyester ◽  
Biological Response ◽  
Bone Graft Substitute ◽  
Calvarial Defect ◽  
Defect Model ◽  
Rat Calvarial Defect ◽  
Poly Propylene

ABSTRACTA nanoparticulate-hydroxyapatite filler augmented osteointegration within a resorbable polymer based bone graft substitute designed for orthopaedic and periodontal applications. The unsaturated polyester poly(propylene glycol-co-fumaric acid) (PPF), was used to prepare the bone graft substitute. The nanoparticulate-hydroxyapatite filler was examined in terms of biocompatibility, bony ingrowth and mechanical stability in a rat calvarial defect model. The nano-hydroxyapatite fillerwas compared against a commercially available micrometer-sized hydroxyapatite(HA) filler. Histological analysis indicated that remodeling of the newly formed bone was more advanced in the defect filled with the nano-hydroxyapatite augmented PPF. Mechanical evaluation showed a more rapid increase in stiffness of the nano-hydroxyapatite PPF. Implants of the nano-HA augmented PPF showed more advanced bone formation and recovery of mechanical properties, suggesting an improved biological response to the nano-sized particles.

Evaluation of biocompatibility of α-1,3 galactosyltransferase knockout pig bone graft in a rat calvarial defect model

2014 ◽  
Vol 15 (2) ◽  
pp. 86-91
Author(s):  
Se Eun Kim ◽  
Ga Hoi Choi ◽  
Kyung Mi Shim ◽  
Seok Hwa Choi ◽  
Sang-Myeong Lee ◽  
...  
Keyword(s):  
Bone Graft ◽  
Calvarial Defect ◽  
Defect Model ◽  
Rat Calvarial Defect

scholarly journals Dehydrothermally Cross-Linked Collagen Membrane with a Bone Graft Improves Bone Regeneration in a Rat Calvarial Defect Model

Materials ◽  
2017 ◽  
Vol 10 (8) ◽  
pp. 927 ◽  
Author(s):  
Yin-Zhe An ◽  
Young-Ku Heo ◽  
Jung-Seok Lee ◽  
Ui-Won Jung ◽  
Seong-Ho Choi
Keyword(s):  
Bone Graft ◽  
Bone Regeneration ◽  
Collagen Membrane ◽  
Calvarial Defect ◽  
Defect Model ◽  
Rat Calvarial Defect

Melatonin decorated 3D-printed beta-tricalcium phosphate scaffolds promoting bone regeneration in a rat calvarial defect model

2019 ◽  
Vol 7 (20) ◽  
pp. 3250-3259 ◽  
Author(s):  
Yali Miao ◽  
Yunhua Chen ◽  
Xiao Liu ◽  
Jingjing Diao ◽  
Naru Zhao ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Calvarial Defect ◽  
Defect Model ◽  
Beta Tricalcium Phosphate ◽  
3D Printed ◽  
Rat Calvarial Defect

3D-printed β-TCP scaffolds decorated with melatonin via dopamine mussel-inspired chemistry enhance the osteogenesis and in vivo bone regeneration.

Evaluation of a silica-containing bone graft substitute in a vertebral defect model

2009 ◽  
Vol 9999A ◽  
pp. NA-NA
Author(s):  
Hideo Kobayashi ◽  
A. Simon Turner ◽  
Howard B. Seim ◽  
Teruya Kawamoto ◽  
Thomas W. Bauer
Keyword(s):  
Bone Graft ◽  
Bone Graft Substitute ◽  
Defect Model

scholarly journals Evaluation of New Octacalcium Phosphate-Coated Xenograft in Rats Calvarial Defect Model on Bone Regeneration

Materials ◽  
2020 ◽  
Vol 13 (19) ◽  
pp. 4391
Author(s):  
Yoona Jung ◽  
Won-Hyeon Kim ◽  
Sung-Ho Lee ◽  
Kyung Won Ju ◽  
Eun-Hee Jang ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Graft ◽  
Octacalcium Phosphate ◽  
Autogenous Bone ◽  
Graft Material ◽  
Calvarial Defect ◽  
Bone Area ◽  
Defect Model ◽  
Bone Graft Material ◽  
Experimental Group

Bone graft material is essential for satisfactory and sufficient bone growth which leads to a successful implant procedure. It is classified into autogenous bone, allobone, xenobone and alloplastic materials. Among them, it has been reported that heterogeneous bone graft material has a porous microstructure that increases blood vessels and bone formation, and shows faster bone formation than other types of bone graft materials. We observed new bone tissue formation and bone remodeling using Ti-oss® (Chiyewon Co., Ltd., Guri, Korea), a heterologous bone graft material. Using a Sprague–Dawley rat calvarial defect model to evaluate the bone healing effect of biomaterials, the efficacy of the newly developed xenograft Ti-oss® and Bio-Oss® (Geistilch Pharma AG, Wolhusen, Switzerland). The experimental animals were sacrificed at 8 and 12 weeks after surgery for each group and the experimental site was extracted. The average new bone area for the Ti-oss® experimental group at 8 weeks was 17.6%. The remaining graft material was 22.7% for the experimental group. The average new bone area for the Ti-oss® group was 24.3% at 12 weeks. The remaining graft material was 22.8% for the experimental group. It can be evaluated that the new bone-forming ability of Ti-oss® with octacalcium phosphate (OCP) has the bone-forming ability corresponding to the conventional products.

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