Fluorescent probes for hydrogen sulfide (H2S) and sulfane sulfur and their applications to biological studies

Nitric Oxide ◽  
2015 ◽  
Vol 46 ◽  
pp. 72-79 ◽  
Author(s):  
Kazuhito Shimamoto ◽  
Kenjiro Hanaoka
Keyword(s):  
Hydrogen Sulfide ◽  
Fluorescent Probes ◽  
Sulfane Sulfur ◽  
Biological Studies

Hydrogen Sulfide Increases Endothelial Permeability by Bound Sulfane Sulfur

2014 ◽  
Vol 76 ◽  
pp. S56
Author(s):  
Shuai Yuan ◽  
Arif Yurdagul ◽  
Sibile Pardue ◽  
A. Wayne Orr ◽  
Christopher G. Kevil
Keyword(s):  
Hydrogen Sulfide ◽  
Endothelial Permeability ◽  
Sulfane Sulfur

scholarly journals Lipoic Acid as a Possible Pharmacological Source of Hydrogen Sulfide/Sulfane Sulfur

Molecules ◽  
2017 ◽  
Vol 22 (3) ◽  
pp. 388 ◽  
Author(s):  
Anna Bilska-Wilkosz ◽  
Małgorzata Iciek ◽  
Danuta Kowalczyk-Pachel ◽  
Magdalena Górny ◽  
Maria Sokołowska-Jeżewicz ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Lipoic Acid ◽  
Sulfane Sulfur

scholarly journals Reaction Based Fluorescent Probes for Hydrogen Sulfide

2012 ◽  
Vol 14 (8) ◽  
pp. 2184-2187 ◽  
Author(s):  
Chunrong Liu ◽  
Bo Peng ◽  
Sheng Li ◽  
Chung-Min Park ◽  
A. Richard Whorton ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Fluorescent Probes

scholarly journals Chemical probes for molecular imaging and detection of hydrogen sulfide and reactive sulfur species in biological systems

2015 ◽  
Vol 44 (14) ◽  
pp. 4596-4618 ◽  
Author(s):  
Vivian S. Lin ◽  
Wei Chen ◽  
Ming Xian ◽  
Christopher J. Chang
Keyword(s):  
Hydrogen Sulfide ◽  
Molecular Imaging ◽  
Live Cell Imaging ◽  
Cell Imaging ◽  
Biological Systems ◽  
Molecular Probes ◽  
Chemical Probes ◽  
Sulfur Species ◽  
Sulfane Sulfur ◽  
Reactive Sulfur Species

This review highlights progress in the development of molecular probes for live cell imaging of hydrogen sulfide and other reactive sulfur species, including sulfite, bisulfite, sulfane sulfur species, and S-nitrosothiols.

scholarly journals Low-Cytotoxicity Fluorescent Probes Based on Anthracene Derivatives for Hydrogen Sulfide Detection

2018 ◽  
Vol 6 ◽  
Author(s):  
Xuefang Shang ◽  
Jie Li ◽  
Yaqian Feng ◽  
Hongli Chen ◽  
Wei Guo ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Fluorescent Probes ◽  
Anthracene Derivatives ◽  
Low Cytotoxicity

Effects of aspirin on the levels of hydrogen sulfide and sulfane sulfur in mouse tissues

2010 ◽  
Vol 62 (2) ◽  
pp. 304-310 ◽  
Author(s):  
Anna Bilska ◽  
Małgorzata Iciek ◽  
Inga Kwiecień ◽  
Karol Kaniecki ◽  
Magdalena Paliborek ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Sulfane Sulfur ◽  
Mouse Tissues

scholarly journals Sulfane Sulfur Regulates LasR-Mediated Quorum Sensing and Virulence in Pseudomonas aeruginosa PAO1

Antioxidants ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 1498
Author(s):  
Guanhua Xuan ◽  
Chuanjuan Lü ◽  
Huangwei Xu ◽  
Kai Li ◽  
Huaiwei Liu ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Hydrogen Sulfide ◽  
Quorum Sensing ◽  
Sulfide Oxidation ◽  
Pseudomonas Aeruginosa Pao1 ◽  
Sulfane Sulfur ◽  
Target Dna ◽  
Production Of Hydrogen

Sulfane sulfur, such as inorganic and organic polysulfide (HSn− and RSn−, n > 2), is a common cellular component, produced either from hydrogen sulfide oxidation or cysteine metabolism. In Pseudomonas aeruginosa PAO1, LasR is a quorum sensing master regulator. After binding its autoinducer, LasR binds to its target DNA to activate the transcription of a suite of genes, including virulence factors. Herein, we report that the production of hydrogen sulfide and sulfane sulfur were positively correlated in P. aeruginosa PAO1, and sulfane sulfur was able to modify LasR, which generated Cys188 persulfide and trisulfide and produced a pentasulfur link between Cys201 and Cys203. The modifications did not affect LasR binding to its target DNA site, but made it several-fold more effective than unmodified LasR in activating transcription in both in vitro and in vivo assays. On the contrary, H2O2 inactivates LasR via producing a disulfide bond between Cys201 and Cys203. P. aeruginosa PAO1 had a high cellular sulfane sulfur and high LasR activity in the mid log phase and early stationary phase, but a low sulfane sulfur and low LasR activity in the declination phase. Thus, sulfane sulfur is a new signaling factor in the bacterium, adding another level of control over LasR-mediated quorum sensing and turning down the activity in old cells.

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