The proteasome inhibitor VELCADE® reduces infarction in rat models of focal cerebral ischemia

2006 ◽  
Vol 398 (3) ◽  
pp. 300-305 ◽  
Author(s):  
Nils Henninger ◽  
Kenneth M. Sicard ◽  
James Bouley ◽  
Marc Fisher ◽  
Nancy E. Stagliano
Keyword(s):  
Cerebral Ischemia ◽  
Proteasome Inhibitor ◽  
Focal Cerebral Ischemia ◽  
Rat Models

Neuroprotective effects of neuregulin-1 in rat models of focal cerebral ischemia

2006 ◽  
Vol 1087 (1) ◽  
pp. 180-185 ◽  
Author(s):  
Wen-Ping Guo ◽  
Jie Wang ◽  
Rui-Xi Li ◽  
Yu-Wen Peng
Keyword(s):  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Neuroprotective Effects ◽  
Neuregulin 1 ◽  
Rat Models

scholarly journals Effects of Tissue Type Plasminogen Activator in Embolic versus Mechanical Models of Focal Cerebral Ischemia in Rats

1999 ◽  
Vol 19 (12) ◽  
pp. 1316-1321 ◽  
Author(s):  
Wei Meng ◽  
Xiaoying Wang ◽  
Minoru Asahi ◽  
Tsuneo Kano ◽  
Kazuko Asahi ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Cerebral Perfusion ◽  
Focal Cerebral Ischemia ◽  
Focal Ischemia ◽  
Tissue Type ◽  
Negative Effects ◽  
Tissue Type Plasminogen Activator ◽  
Rat Models ◽  
Type Plasminogen Activator ◽  
Transient Focal Ischemia

Tissue type plasminogen activator (tPA) can be effective therapy for embolic stroke by restoring cerebral perfusion. However, a recent experimental study showed that tPA increased infarct size in a mouse model of transient focal ischemia, suggesting a possible adverse effect of tPA on ischemic tissue per se. In this report, the effects of tPA in two rat models of cerebral ischemia were compared. In experiment 1, rats were subjected to focal ischemia via injection of autologous clots into the middle cerebral artery territory. Two hours after clot injection, rats were treated with 10 mg/kg tPA or normal saline. Perfusion-sensitive computed tomography scanning showed that tPA restored cerebral perfusion in this thromboembolic model. Treatment with tPA significantly reduced ischemic lesion volumes measured at 24 hours by >60%. In experiment 2, three groups of rats were subjected to focal ischemia via a mechanical approach in which a silicon-coated filament was used intraluminally to occlude the origin of the middle cerebral artery. In two groups, the filament was withdrawn after 2 hours to allow for reperfusion, and then rats were randomly treated with 10 mg/kg tPA or normal saline. In the third group, rats were not treated and the filament was not withdrawn so that permanent focal ischemia was present. In this experiment, tPA did not significantly alter lesion volumes after 2 hours of transient focal ischemia. In contrast, permanent ischemia significantly increased lesion volumes by 55% compared with transient ischemia. These results indicate that in these rat models of focal cerebral ischemia, tPA did not have detectable negative effects. Other potentially negative effects of tPA may be dependent on choice of animal species and model systems.

scholarly journals Improvement of the suture-occluded method in rat models of focal cerebral ischemia-reperfusion

2014 ◽  
Vol 7 (3) ◽  
pp. 657-662 ◽  
Author(s):  
PING ZHANG ◽  
ZHEN HUANG ◽  
HAI-QING YAN ◽  
LIN-LIN SU ◽  
YONG-KUN GUI ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Ischemia Reperfusion ◽  
Rat Models ◽  
Cerebral Ischemia Reperfusion

scholarly journals Effect of Panax notoginseng Saponins on Focal Cerebral Ischemia-Reperfusion in Rat Models: A Meta-Analysis

2021 ◽  
Vol 11 ◽  
Author(s):  
Tao Sun ◽  
Ping Wang ◽  
Ting Deng ◽  
Xingbao Tao ◽  
Bin Li ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Cerebral Ischemia ◽  
Combination Treatment ◽  
Focal Cerebral Ischemia ◽  
Ischemia Reperfusion ◽  
Meta Analysis ◽  
Panax Notoginseng ◽  
Drug Dosage ◽  
Rat Models ◽  
Cerebral Ischemia Reperfusion

With the increase of the aging population, the high mortality and disability rates caused by ischemic stroke are some of the major problems facing the world, and they dramatically burden the society. Panax notoginseng (Burk) F. H. Chen, a traditional Chinese medicine, is commonly used for promoting blood circulation and removing blood stasis, and its main bioactive components are Panax notoginseng saponins (PNS). Therefore, we performed a meta-analysis on focal cerebral ischemia-reperfusion animal models established with middle cerebral artery occlusion (MCAO) surgery to evaluate the therapeutic effect of PNS. We systematically searched the reports of PNS in MCAO animal experiments in seven databases. We assessed the study quality using two literature quality evaluation criteria; evaluated the efficacy of PNS treatment based on the outcomes of the neurological deficit score (NDS), cerebral infarct volume (CIV), and biochemical indicators via a random/fixed-effects model; and performed a subgroup analysis utilizing ischemia duration, drug dosage, intervention time, and administration duration. We also compared the efficacy of PNS with positive control drugs or combination treatment. As a result, we selected 14 eligible studies from the 3,581 searched publications based on the predefined exclusion-inclusion criteria. PNS were significantly associated with reduced NDS, reduced CIV, and inhibited release of the inflammatory factors IL-1β and TNF-α in the focal MCAO rat models. The PNS combination therapy outperformed the PNS alone. In addition, ischemia time, drug dosage, intervention time, and administration duration in the rat models all had significant effects on the efficacy of PNS. Although more high-quality studies are needed to further determine the clinical efficacy and guiding parameters of PNS, our results also confirmed that PNS significantly relieves the focal cerebral ischemia-reperfusion in rat models. In the animal trials, it was suggested that an early intervention had significant efficacy with PNS alone or PNS combination treatment at a dosage lower than 25 mg/kg or 100–150 mg/kg for 4 days or longer. These findings further guide the therapeutic strategy for clinical cerebral ischemic stroke.

scholarly journals Proteasome Inhibitor PS519 Reduces Infarction and Attenuates Leukocyte Infiltration in a Rat Model of Focal Cerebral Ischemia

Stroke ◽  
2000 ◽  
Vol 31 (7) ◽  
pp. 1686-1693 ◽  
Author(s):  
James B. Phillips ◽  
Anthony J. Williams ◽  
Julian Adams ◽  
Peter J. Elliott ◽  
Frank C. Tortella
Keyword(s):  
Cerebral Ischemia ◽  
Rat Model ◽  
Proteasome Inhibitor ◽  
Focal Cerebral Ischemia ◽  
Leukocyte Infiltration
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