Neuroprotective effects of neuregulin-1 in rat models of focal cerebral ischemia

2006 ◽  
Vol 1087 (1) ◽  
pp. 180-185 ◽  
Author(s):  
Wen-Ping Guo ◽  
Jie Wang ◽  
Rui-Xi Li ◽  
Yu-Wen Peng
Keyword(s):  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Neuroprotective Effects ◽  
Neuregulin 1 ◽  
Rat Models

The proteasome inhibitor VELCADE® reduces infarction in rat models of focal cerebral ischemia

2006 ◽  
Vol 398 (3) ◽  
pp. 300-305 ◽  
Author(s):  
Nils Henninger ◽  
Kenneth M. Sicard ◽  
James Bouley ◽  
Marc Fisher ◽  
Nancy E. Stagliano
Keyword(s):  
Cerebral Ischemia ◽  
Proteasome Inhibitor ◽  
Focal Cerebral Ischemia ◽  
Rat Models

Therapeutic Neuroprotective Effects of XQ-1H in a Rat Model of Permanent Focal Cerebral Ischemia

Pharmacology ◽  
2012 ◽  
Vol 89 (1-2) ◽  
pp. 1-6 ◽  
Author(s):  
Qichuan Yang ◽  
Weirong Fang ◽  
Peng Lv ◽  
Xiaohan Geng ◽  
Yunman Li ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Rat Model ◽  
Focal Cerebral Ischemia ◽  
Neuroprotective Effects

Involvement of Erythropoietin Expression in Acupuncture Preconditioning-Induced Ischemic Tolerance

2012 ◽  
Vol 554-556 ◽  
pp. 1650-1655 ◽  
Author(s):  
Xue Mei Han ◽  
Hong Tao Wei ◽  
Song Yan Liu
Keyword(s):  
Endothelial Cells ◽  
In Situ Hybridization ◽  
Cerebral Ischemia ◽  
Vascular Endothelial Cells ◽  
Focal Cerebral Ischemia ◽  
Peripheral Zone ◽  
Vascular Endothelial ◽  
Neuroprotective Effects ◽  
Protein Expressions

Abstract Objective To investigate the expression of erythropoietin (EPO) after acupuncture preconditioning plus focal cerebral ischemia treatment. Methods Rat focal cerebral ischemia model and acupuncture preconditioning model were established. Animals were randomly assigned into different groups: control (focal cerebral ischemia) and acupuncture preconditioning plus focal cerebral ischemia, with 8 rats for each group. The expression of EPO after different treatments was determined by histological examination, immunohistochemistry and in situ hybridization. Results The mRNA and protein expressions of EPO could be detected in survival and necrotic neurons, glia as well as vascular endothelial cells. Focal cerebral ischemia promoted the expression of EPO. Significant enhanced EPO level was found in the ischemic peripheral zone after acupuncture preconditioning (P < 0.05). Conclusion Our results demonstrated that acupuncture preconditioning enhanced the expression of EPO in neurons, glia and vascular endothelial cells the ischemic peripheral zone, suggesting the involvement of EPO in acupuncture preconditioning-induced neuroprotection following focal cerebral ischemia. EPO may exert neuroprotective effects through promoting neurotrophic support and angiogenesis.

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