Glutathione metabolism is modulated by postmortem interval, gender difference and agonal state in postmortem human brains

2011 ◽  
Vol 59 (7) ◽  
pp. 1029-1042 ◽  
Author(s):  
G. Harish ◽  
C. Venkateshappa ◽  
Anita Mahadevan ◽  
Nupur Pruthi ◽  
M.M. Srinivas Bharath ◽  
...  
Keyword(s):  
Gender Difference ◽  
Postmortem Interval ◽  
Glutathione Metabolism ◽  
Human Brains ◽  
Agonal State

scholarly journals Lower brain pH as a shared endophenotype of psychotic disorders

2016 ◽  
Author(s):  
Hideo Hagihara ◽  
Vibeke S Catts ◽  
Yuta Katayama ◽  
Tsuyoshi Takagi ◽  
Freesia L Huang ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Mouse Models ◽  
Psychotic Disorders ◽  
Meta Analysis ◽  
Significant Negative Correlation ◽  
Autism Spectrum ◽  
Postmortem Interval ◽  
Brain Ph ◽  
Lactate Levels ◽  
Agonal State

AbstractLower pH is a well-replicated finding in the postmortem brains of patients with schizophrenia and bipolar disorder. Interpretation of the data, however, is controversial as to whether this finding reflects a primary feature of the diseases or is a result of confounding factors such as medication, postmortem interval, and agonal state. To date, systematic investigation of brain pH has not been undertaken using animal models, which can be studied without confounds inherent in human studies. In the present study, we first confirmed that the brains of patients with schizophrenia and bipolar disorder exhibit lower pH values by conducting a meta-analysis of existing datasets. We then utilized neurodevelopmental mouse models of psychiatric disorders in order to test the hypothesis that lower brain pH exists in these brains compared to controls due to the underlying pathophysiology of the disorders. We measured pH, lactate levels, and related metabolite levels in brain homogenates from three mouse models of schizophrenia (Schnurri-2 KO, forebrain-specific calcineurin KO, and neurogranin KO mice) and one of bipolar disorder (Camk2a HKO mice), and one of autism spectrum disorders (Chd8 HKO mice). All mice were drug-naïve with the same postmortem interval and agonal state at death. Upon postmortem examination, we observed significantly lower pH and higher lactate levels in the brains of model mice relative to controls. There was a significant negative correlation between pH and lactate levels. These results suggest that lower pH associated with increased lactate levels is a pathophysiology of such diseases rather than mere artifacts.

scholarly journals Gender Difference in Human Neonatal Glutathione Metabolism: Gender Difference in the Cellular Uptake of Cysteine

1999 ◽  
Vol 45 (4, Part 2 of 2) ◽  
pp. 286A-286A
Author(s):  
Jean-Claude Lavoie ◽  
Therese Rouleau ◽  
Philippe Chessex
Keyword(s):  
Gender Difference ◽  
Cellular Uptake ◽  
Glutathione Metabolism

Gender difference in clinical presentation of primary hyperparathyroidism

2017 ◽  
Author(s):  
Laura Gianotti ◽  
Elena Castellano ◽  
Francesco Tassone ◽  
Claudia Baffoni ◽  
Flora Cesario ◽  
...  
Keyword(s):  
Gender Difference ◽  
Primary Hyperparathyroidism ◽  
Clinical Presentation

Effects of High BMI on Synaptic Function and Metabolic Connectivity in the Brain—Evidence of Gender Difference

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 363-OR ◽  
Author(s):  
ARIANNA SALA ◽  
MAURA MALPETTI ◽  
ANNA FERRULLI ◽  
LUIGI GIANOLLI ◽  
LIVIO LUZI ◽  
...  
Keyword(s):  
Gender Difference ◽  
Synaptic Function ◽  
Metabolic Connectivity ◽  
The Brain ◽  
High Bmi
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