Estrogen enhances expression of the complement C5a receptor and the C5a-agonist evoked calcium influx in hormone secreting neurons of the hypothalamus

2008 ◽  
Vol 52 (4-5) ◽  
pp. 846-856 ◽  
Author(s):  
Imre Farkas ◽  
Patricia Varju ◽  
Emese Szabo ◽  
Erik Hrabovszky ◽  
Noriko Okada ◽  
...  
Keyword(s):  
Calcium Influx ◽  
C5a Receptor ◽  
Complement C5a

scholarly journals Deletion of the Complement C5a Receptor Alleviates the Severity of Acute Pneumococcal Otitis Media following Influenza A Virus Infection in Mice

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e95160 ◽  
Author(s):  
Hua Hua Tong ◽  
Garrett Lambert ◽  
Yong Xing Li ◽  
Joshua M. Thurman ◽  
Gregory L. Stahl ◽  
...  
Keyword(s):  
Virus Infection ◽  
Otitis Media ◽  
Influenza A Virus ◽  
Influenza A ◽  
C5a Receptor ◽  
Influenza A Virus Infection ◽  
Complement C5a

Atypical complement receptor C5aR2 transports C5a to initiate neutrophil adhesion and inflammation

2019 ◽  
Vol 4 (35) ◽  
pp. eaav5951 ◽  
Author(s):  
Yoshishige Miyabe ◽  
Chie Miyabe ◽  
Vinidhra Mani ◽  
Thorsten R. Mempel ◽  
Andrew D. Luster
Keyword(s):  
Endothelial Cells ◽  
Blood Vessel ◽  
Chemokine Receptor ◽  
Murine Model ◽  
Neutrophil Adhesion ◽  
Complement Receptor ◽  
C5a Receptor ◽  
Vessel Lumen ◽  
Chemokine Ligands ◽  
Complement C5a

Chemoattractant-induced arrest of circulating leukocytes and their subsequent diapedesis is a fundamental component of inflammation. However, how tissue-derived chemoattractants are transported into the blood vessel lumen to induce leukocyte entry into tissue is not well understood. Here, intravital microscopy in live mice has shown that the “atypical” complement C5a receptor 2 (C5aR2) and the atypical chemokine receptor 1 (ACKR1) expressed on endothelial cells were required for the transport of C5a and CXCR2 chemokine ligands, respectively, into the vessel lumen in a murine model of immune complex–induced arthritis. Transported C5a was required to initiate C5aR1-mediated neutrophil arrest, whereas transported chemokines were required to initiate CXCR2-dependent neutrophil transdendothelial migration. These findings provide new insights into how atypical chemoattractant receptors collaborate with “classical” signaling chemoattractant receptors to control distinct steps in the recruitment of neutrophils into tissue sites of inflammation.

Intracerebral complement C5a receptor (CD88) expression is regulated by TNF and lymphotoxin-α following closed head injury in mice

2000 ◽  
Vol 109 (2) ◽  
pp. 164-172 ◽  
Author(s):  
Philip F Stahel ◽  
Karin Kariya ◽  
Esther Shohami ◽  
Scott R Barnum ◽  
Hans-Pietro Eugster ◽  
...  
Keyword(s):  
Head Injury ◽  
Closed Head Injury ◽  
C5a Receptor ◽  
Closed Head ◽  
Complement C5a ◽  
Lymphotoxin Α

M cells expressing the complement C5a receptor are efficient targets for mucosal vaccine delivery

2011 ◽  
Vol 41 (11) ◽  
pp. 3219-3229 ◽  
Author(s):  
Sae-Hae Kim ◽  
Dae-Im Jung ◽  
In-Young Yang ◽  
Ju Kim ◽  
Kyung-Yeol Lee ◽  
...  
Keyword(s):  
Vaccine Delivery ◽  
Mucosal Vaccine ◽  
M Cells ◽  
C5a Receptor ◽  
Complement C5a

Blockade of the Complement C5a Receptor Reduces Incisional Allodynia, Edema, and Cytokine Expression

2006 ◽  
Vol 104 (6) ◽  
pp. 1274-1282 ◽  
Author(s):  
J David Clark ◽  
Yanli Qiao ◽  
Xiangqi Li ◽  
Xiaoyou Shi ◽  
Martin S. Angst ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Complement System ◽  
Messenger Rna ◽  
Receptor Expression ◽  
Daily Injection ◽  
Edema Formation ◽  
C5a Receptor ◽  
Surgical Incisions ◽  
Complement C5a ◽  
The Complement System

Background Activation of the complement system is one component of the inflammatory response. Various components of the complement system participate in killing foreign organisms, recruiting immune cells, enhancing edema, and stimulating cytokine formation. Complement-mediated enhancement of the inflammation surrounding surgical incisions may increase pain. Methods In these studies, the authors used a murine hind paw incisional model to study the role of the complement C5a receptor in supporting incisional inflammation. At baseline and at various time points after incision, they measured the effects of a highly selective C5a receptor antagonist on nociceptive thresholds, edema formation, and cytokine production in the skin surrounding the incision. They also measured changes in C5a receptor expression near the incisions. Results The once-daily injection of the C5a receptor antagonist AcF-[OPdChaWR] reduced mechanical allodynia and edema in the incised hind paw. A multiplexed cytokine assay revealed that 8 of the 18 cytokines examined showed significant increases in skin tissue abundance after incision. Distinct time courses for the patterns of elevation were seen, though some degree of resolution occurred for all cytokines within 96 h. For 7 of these 8 cytokines, the C5a receptor antagonist reduced the enhancement of expression. In addition, the authors found that the C5a receptor messenger RNA level increased 15-fold in the skin surrounding the incisions within 24 h and then slowly declined. Conclusions The tissue directly surrounding incisions in mouse hind paws undergoes large changes in the content of specific cytokines in addition to demonstrating edema and nociceptive sensitization. By blocking the receptor for one component of the complement system, C5a, all of these changes can be reduced. Complement receptor inhibitors may constitute a novel group of compounds useful in reducing the pain and swelling of surgical incisions.

scholarly journals Expression of complement C5a receptor and the viability of 4T1 tumor cells following agonist–antagonist treatment

2016 ◽  
Vol 12 (2) ◽  
pp. 590
Author(s):  
MohdHezmee Mohd Noor ◽  
NurneqmanNashreq Kosni ◽  
Norhaifa Ganti ◽  
IntanShameha Abdul Razak ◽  
MohdMokrish Md Ajat ◽  
...  
Keyword(s):  
Tumor Cells ◽  
C5a Receptor ◽  
Complement C5a
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