M cells expressing the complement C5a receptor are efficient targets for mucosal vaccine delivery

2011 ◽  
Vol 41 (11) ◽  
pp. 3219-3229 ◽  
Author(s):  
Sae-Hae Kim ◽  
Dae-Im Jung ◽  
In-Young Yang ◽  
Ju Kim ◽  
Kyung-Yeol Lee ◽  
...  
Keyword(s):  
Vaccine Delivery ◽  
Mucosal Vaccine ◽  
M Cells ◽  
C5a Receptor ◽  
Complement C5a

scholarly journals Lactic Acid Bacteria as Vectors: A Novel Approach for Mucosal Vaccine Delivery

2018 ◽  
Vol 09 (02) ◽  
Author(s):  
Beenish Israr ◽  
Jaehan Kim ◽  
Sidra Anam ◽  
Faisal Rasheed Anjum
Keyword(s):  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Vaccine Delivery ◽  
Mucosal Vaccine ◽  
Novel Approach

scholarly journals Deletion of the Complement C5a Receptor Alleviates the Severity of Acute Pneumococcal Otitis Media following Influenza A Virus Infection in Mice

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e95160 ◽  
Author(s):  
Hua Hua Tong ◽  
Garrett Lambert ◽  
Yong Xing Li ◽  
Joshua M. Thurman ◽  
Gregory L. Stahl ◽  
...  
Keyword(s):  
Virus Infection ◽  
Otitis Media ◽  
Influenza A Virus ◽  
Influenza A ◽  
C5a Receptor ◽  
Influenza A Virus Infection ◽  
Complement C5a

Estrogen enhances expression of the complement C5a receptor and the C5a-agonist evoked calcium influx in hormone secreting neurons of the hypothalamus

2008 ◽  
Vol 52 (4-5) ◽  
pp. 846-856 ◽  
Author(s):  
Imre Farkas ◽  
Patricia Varju ◽  
Emese Szabo ◽  
Erik Hrabovszky ◽  
Noriko Okada ◽  
...  
Keyword(s):  
Calcium Influx ◽  
C5a Receptor ◽  
Complement C5a

Atypical complement receptor C5aR2 transports C5a to initiate neutrophil adhesion and inflammation

2019 ◽  
Vol 4 (35) ◽  
pp. eaav5951 ◽  
Author(s):  
Yoshishige Miyabe ◽  
Chie Miyabe ◽  
Vinidhra Mani ◽  
Thorsten R. Mempel ◽  
Andrew D. Luster
Keyword(s):  
Endothelial Cells ◽  
Blood Vessel ◽  
Chemokine Receptor ◽  
Murine Model ◽  
Neutrophil Adhesion ◽  
Complement Receptor ◽  
C5a Receptor ◽  
Vessel Lumen ◽  
Chemokine Ligands ◽  
Complement C5a

Chemoattractant-induced arrest of circulating leukocytes and their subsequent diapedesis is a fundamental component of inflammation. However, how tissue-derived chemoattractants are transported into the blood vessel lumen to induce leukocyte entry into tissue is not well understood. Here, intravital microscopy in live mice has shown that the “atypical” complement C5a receptor 2 (C5aR2) and the atypical chemokine receptor 1 (ACKR1) expressed on endothelial cells were required for the transport of C5a and CXCR2 chemokine ligands, respectively, into the vessel lumen in a murine model of immune complex–induced arthritis. Transported C5a was required to initiate C5aR1-mediated neutrophil arrest, whereas transported chemokines were required to initiate CXCR2-dependent neutrophil transdendothelial migration. These findings provide new insights into how atypical chemoattractant receptors collaborate with “classical” signaling chemoattractant receptors to control distinct steps in the recruitment of neutrophils into tissue sites of inflammation.

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