Osteogenic and angiogenic potentials of the cell-laden hydrogel/mussel-inspired calcium silicate complex hierarchical porous scaffold fabricated by 3D bioprinting

2018 ◽  
Vol 91 ◽  
pp. 679-687 ◽  
Author(s):  
Yi-Wen Chen ◽  
Yu-Fang Shen ◽  
Chia-Che Ho ◽  
Joyce Yu ◽  
Yuan-Haw Andrew Wu ◽  
...  
Keyword(s):  
Calcium Silicate ◽  
Porous Scaffold ◽  
3D Bioprinting ◽  
Hierarchical Porous ◽  
Silicate Complex

scholarly journals Multinozzle Multichannel Temperature Deposition System for Construction of a Blood Vessel

2017 ◽  
Vol 23 (1) ◽  
pp. 64-69 ◽  
Author(s):  
Huanbao Liu ◽  
Huixing Zhou ◽  
Haiming Lan ◽  
Fu Liu ◽  
Xuhan Wang
Keyword(s):  
Tissue Engineering ◽  
Blood Vessel ◽  
3D Model ◽  
Model Structure ◽  
3D Bioprinting ◽  
Porous Structures ◽  
Bioactive Materials ◽  
Organ Regeneration ◽  
Hierarchical Porous ◽  
Temperature Deposition

3D bioprinting is an emerging technology that drives us to construct the complicated tissues and organs consisting of various materials and cells, which has been in widespread use in tissue engineering and organ regeneration. However, the protection and accurate distribution of cells are the most urgent problems to achieve tissue and organ reconstruction. In this article, a multinozzle multichannel temperature deposition and manufacturing (MTDM) system is proposed to fabricate a blood vessel with heterogeneous materials and gradient hierarchical porous structures, which enables not only the reconstruction of a blood vessel with an accurate 3D model structure but also the capacity to distribute bioactive materials such as growth factors, nutrient substance, and so on. In addition, a coaxial focusing nozzle is proposed and designed to extrude the biomaterial and encapsulation material, which can protect the cell from damage. In the MTDM system, the tubular structure of a blood vessel was successfully fabricated with the different biomaterials, which proved that the MTDM system has a potential application prospect in tissue engineering and organ regeneration.

scholarly journals Applying macromolecular crowding to 3D bioprinting: fabrication of 3D hierarchical porous collagen-based hydrogel constructs

2018 ◽  
Vol 6 (3) ◽  
pp. 562-574 ◽  
Author(s):  
Wei Long Ng ◽  
Min Hao Goh ◽  
Wai Yee Yeong ◽  
May Win Naing
Keyword(s):  
Tissue Engineering ◽  
Macromolecular Crowding ◽  
3D Bioprinting ◽  
Porous Structures ◽  
Hierarchical Porous

3D bioprinting of hierarchical porous structures for tissue engineering.

scholarly journals 3D-Printed Ginsenoside Rb1-Loaded Mesoporous Calcium Silicate/Calcium Sulfate Scaffolds for Inflammation Inhibition and Bone Regeneration

Biomedicines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 907
Author(s):  
Cheng-Yu Chen ◽  
Ming-You Shie ◽  
Alvin Kai-Xing Lee ◽  
Yun-Ting Chou ◽  
Chun Chiang ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Calcium Silicate ◽  
Calcium Sulfate ◽  
Porous Scaffold ◽  
Chemical Characteristic ◽  
Chinese History ◽  
Ginsenoside Rb1 ◽  
Related Protein ◽  
3D Scaffold

Bone defects are commonly found in the elderly and athletic population due to systemic diseases such as osteoporosis and trauma. Bone scaffolds have since been developed to enhance bone regeneration by acting as a biological extracellular scaffold for cells. The main advantage of a bone scaffold lies in its ability to provide various degrees of structural support and growth factors for cellular activities. Therefore, we designed a 3D porous scaffold that can not only provide sufficient mechanical properties but also carry drugs and promote cell viability. Ginsenoside Rb1 (GR) is an extract from panax ginseng, which has been used for bone regeneration and repair since ancient Chinese history. In this study, we fabricated scaffolds using various concentrations of GR with mesoporous calcium silicate/calcium sulfate (MSCS) and investigated the scaffold’s physical and chemical characteristic properties. PrestoBlue, F-actin staining, and ELISA were used to demonstrate the effect of the GR-contained MSCS scaffold on cell proliferation, morphology, and expression of the specific osteogenic-related protein of human dental pulp stem cells (hDPSCs). According to our data, hDPSCs cultivated in GR-contained MSCS scaffold had preferable abilities of proliferation and higher expression of the osteogenic-related protein and could effectively inhibit inflammation. Finally, in vivo performance was assessed using histological results that revealed the GR-contained MSCS scaffolds were able to further achieve more effective hard tissue regeneration than has been the case in the past. Taken together, this study demonstrated that a GR-containing MSCS 3D scaffold could be used as a potential alternative for future bone tissue engineering studies and has good potential for clinical use.

Effect of hierarchical porous scaffold on osteoimmunomodulation and bone formation

2020 ◽  
Vol 20 ◽  
pp. 100779
Author(s):  
Yang Liu ◽  
Lingyan Cao ◽  
Shuang Zhang ◽  
Luli Ji ◽  
Jing Wang ◽  
...  
Keyword(s):  
Bone Formation ◽  
Porous Scaffold ◽  
Hierarchical Porous

A novel Roll Porous Scaffold 3D bioprinting technology

Bioprinting ◽  
2019 ◽  
Vol 13 ◽  
pp. e00042 ◽  
Author(s):  
Vyacheslav Shulunov
Keyword(s):  
Porous Scaffold ◽  
3D Bioprinting

Calcium silicate-poly(n-butyl-2-cyanoacrylate) nanocomposite for bone tissue adhesion

2019 ◽  
Vol 110 (4) ◽  
pp. 359-366 ◽  
Author(s):  
Rosa M. Guerra Bretaña ◽  
Lídia A. de Sena ◽  
Marilia S. Beltrão ◽  
Rodrigo F. Resende ◽  
Suelen C. Sartoretto ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Calcium Silicate ◽  
Tissue Adhesion
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