scholarly journals Tailored sequential drug release from bilayered calcium sulfate composites

2014 ◽  
Vol 43 ◽  
pp. 243-252 ◽  
Author(s):  
Bryan R. Orellana ◽  
David A. Puleo
Keyword(s):  
Drug Release ◽  
Calcium Sulfate ◽  
Sequential Drug Release

scholarly journals Correction to Supramolecular Drug–Drug Complex Vesicles Enable Sequential Drug Release for Enhanced Combination Therapy

2020 ◽  
Vol 12 (39) ◽  
pp. 44382-44382
Author(s):  
Chengfei Liu ◽  
Chunpu Li ◽  
Cui Pang ◽  
Muqiong Li ◽  
Huixin Li ◽  
...  
Keyword(s):  
Drug Release ◽  
Combination Therapy ◽  
Sequential Drug Release ◽  
Drug Complex

STUDY OF THE DIFFERENT RELEASE CHARACTERISTICS OF ANTIBIOTICS FROM PATIENTS: A DYNAMIC ELUTING SYSTEM TO INVESTIGATE DRUG RELEASE FROM ANTIBIOTIC-IMPREGNATED CALCIUM SULFATE DELIVERY

2015 ◽  
Vol 15 (01) ◽  
pp. 1550012
Author(s):  
YANG ZHANG ◽  
RENJIE WU ◽  
YING HU ◽  
YU DONG ◽  
LIFENG SHEN ◽  
...  
Keyword(s):  
Drug Release ◽  
Delivery System ◽  
Release Rate ◽  
Calcium Sulfate ◽  
Fickian Diffusion ◽  
Release Behavior ◽  
Cumulative Release ◽  
In Vivo Release

Background: Antibiotic-impregnated calcium sulfate delivery systems (ACDS) are commonly used to treat chronic osteomyelitis. Our research is to investigate drug release in vitro over a longer period, as a cautious predictor of in vivo release. Methods: The local release behavior of antibiotic in vitro was simulated. The consecutive dynamic eluting experiment was performed based on the pro-operative characteristic of osteomyelitis patients and the determined results of drug concentration in the human drainage tissue fluid (DTF). The concentration of each drug in the receiving solution was detected by ultra-performance liquid chromatography-tandem quadrupole detector mass spectrometry. The ACDS was reviewed by scanning electronic microscopy (SEM) after 48 h, and prepared to be eluted for another examination after 33 days. The mechanism of antibiotic release was analyzed by using the Ritger–Peppas and Weibull equations. Results: The cumulative release rate of vancomycin in a vancomycin-calcium sulfate delivery system (VCDS) was 77.50 % (3.0 mm diameter) and 72.43 % (4.8 mm diameter), while that of the tobramycin in a tobramycin-calcium sulfate delivery system (TCDS) was 88.0 % (3.0 mm diameter) and 84.55 % (4.8 mm diameter). At the 15th day, approximately 27.92% of vancomycin was and 29.35% of tobramycin was released from the local implant in vivo. Using SEM, numerous vancomycin and tobramycin particles were found to be attached to the columnar calcium sulfate crystals at the start of the experiment. The release behavior of the two antibiotics followed a combination of Fickian diffusion and Case II transport mechanisms within the first 48 h, and a Fickian diffusion mechanism during the subsequent time period. The correlation coefficient of tobramycin and vancomycin in vivo and in vitro was 0.9704–0.9949 and 0.9549–0.9782, respectively. Conclusion: A good correlation of the in vivo and in vitro cumulative release rates was observed by comparing the cumulative release rate of drugs in vitro by means of the dynamic eluting model, and in the DTF. Therefore, our study has proved that it is possible to use the dynamic eluting model as a cautious predictor of in vivo release.

Sequential drug release for synergistic cancer treatment and immunity promotion

RSC Advances ◽  
2013 ◽  
Vol 3 (32) ◽  
pp. 13399 ◽  
Author(s):  
Mingsheng Chen ◽  
Xinyuan Zhu ◽  
Deyue Yan
Keyword(s):  
Drug Release ◽  
Cancer Treatment ◽  
Sequential Drug Release

scholarly journals Drug release from calcium sulfate-based composites

2014 ◽  
Vol 103 (1) ◽  
pp. 135-142 ◽  
Author(s):  
Bryan R. Orellana ◽  
J. Zach Hilt ◽  
David A. Puleo
Keyword(s):  
Drug Release ◽  
Calcium Sulfate

scholarly journals A NAG-Guided Nano-Delivery System for Redox- and pH-Triggered Intracellularly Sequential Drug Release in Cancer Cells

2020 ◽  
Vol Volume 15 ◽  
pp. 841-855
Author(s):  
Yan Liang ◽  
Jing Zhang ◽  
Baocheng Tian ◽  
Zimei Wu ◽  
Darren Svirskis ◽  
...  
Keyword(s):  
Drug Release ◽  
Cancer Cells ◽  
Delivery System ◽  
Sequential Drug Release

scholarly journals Dual-generation dendritic mesoporous silica nanoparticles for co-delivery and kinetically sequential drug release

RSC Advances ◽  
2018 ◽  
Vol 8 (71) ◽  
pp. 40598-40610 ◽  
Author(s):  
Yanxin Liu ◽  
Baolin Huang ◽  
Jiaoyang Zhu ◽  
Kailin Feng ◽  
Yuan Yuan ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Sequential Drug Release

The designed DAMSN could simultaneously load IBU and BSA, and realize sequential drug release efficiently.

scholarly journals Assessment of the Release of Vascular Endothelial Growth Factor from 3D-Printed Poly-ε-Caprolactone/Hydroxyapatite/Calcium Sulfate Scaffold with Enhanced Osteogenic Capacity

Polymers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1455 ◽  
Author(s):  
Cheng-Yu Chen ◽  
Chien-Chang Chen ◽  
Chen-Ying Wang ◽  
Alvin Kai-Xing Lee ◽  
Chun-Liang Yeh ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Drug Release ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Calcium Sulfate ◽  
Potential Candidate ◽  
Vascular Endothelial ◽  
Fused Deposition ◽  
Endothelial Growth Factor

Vascular endothelial growth factor (VEGF) is one of the most crucial growth factors and an assistant for the adjustment of bone regeneration. In this study, a 3D scaffold is fabricated using the method of fused deposition modeling. Such a fabricated method allows us to fabricate scaffolds with consistent pore sizes, which could promote cellular ingrowth into scaffolds. Therefore, we drafted a plan to accelerate bone regeneration via VEGF released from the hydroxyapatite/calcium sulfate (HACS) scaffold. Herein, HACS will gradually degrade and provide a suitable environment for cell growth and differentiation. In addition, HACS scaffolds have higher mechanical properties and drug release compared with HA scaffolds. The drug release profile of the VEGF-loaded scaffolds showed that VEGF could be loaded and released in a stable manner. Furthermore, initial results showed that VEGF-loaded scaffolds could significantly enhance the proliferation of human mesenchymal stem cells (hMSCs) and human umbilical vein endothelial cells (HUVEC). In addition, angiogenic- and osteogenic-related proteins were substantially increased in the HACS/VEGF group. Moreover, in vivo results revealed that HACS/VEGF improved the regeneration of the rabbit’s femur bone defect, and VEGF loading improved bone tissue regeneration and remineralization after implantation for 8 weeks. All these results strongly imply that the strategy of VEGF loading onto scaffolds could be a potential candidate for future bone tissue engineering.

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