Role of complement cascade in experimental autoimmune blistering disease bullous pemphigoid

2007 ◽  
Vol 44 (1-3) ◽  
pp. 158
Author(s):  
Kelly E. Carter ◽  
Pamela A. Rose ◽  
Minglang Zhao ◽  
Rick A. Wetsel ◽  
Luis A. Diaz ◽  
...  
Keyword(s):  
Bullous Pemphigoid ◽  
Complement Cascade ◽  
Autoimmune Blistering Disease ◽  
Blistering Disease ◽  
Experimental Autoimmune

scholarly journals The Role of Intereukin-31 in Pathogenesis of Itch and Its Intensity in a Course of Bullous Pemphigoid and Dermatitis Herpetiformis

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Lilianna Kulczycka-Siennicka ◽  
Anna Cynkier ◽  
Elżbieta Waszczykowska ◽  
Anna Woźniacka ◽  
Agnieszka Żebrowska
Keyword(s):  
Signaling Pathway ◽  
Bullous Pemphigoid ◽  
Dermatitis Herpetiformis ◽  
Subjective Symptoms ◽  
Autoimmune Blistering Disease ◽  
Stat Signaling ◽  
Blistering Disease ◽  
Autoimmune Blistering Diseases

Itch which is one of the major, subjective symptoms in a course of bullous pemphigoid and dermatitis herpetiformis makes those two diseases totally different than other autoimmune blistering diseases. Its pathogenesis is still not fully known. The aim of this research was to assess the role of IL-31 in development of itch as well as to measure its intensity. Obtained results, as well as literature data, show that lower concentration of IL-31 in patients’ serum may be correlated with its role in JAK/STAT signaling pathway which is involved in development of autoimmune blistering disease. Intensity of itch is surprisingly huge problem for the patients and the obtained results are comparable with results presented by atopic patients.

scholarly journals Linear IGA bullous dermatosis potentially triggered by vaccination

2022 ◽  
Vol 36 ◽  
pp. 205873842110212
Author(s):  
Alberto Corrà ◽  
Veronica Bonciolini ◽  
Lavinia Quintarelli ◽  
Alice Verdelli ◽  
Marzia Caproni
Keyword(s):  
Basement Membrane Zone ◽  
Dermoepidermal Junction ◽  
Pathogenetic Role ◽  
Autoimmune Blistering Disease ◽  
Bullous Dermatosis ◽  
Iga Antibodies ◽  
Blistering Disease ◽  
Adults And Children ◽  
Linear Iga Bullous Dermatosis

Linear IgA bullous dermatosis (LABD) is a mucocutaneous autoimmune blistering disease affecting both adults and children. It is caused by IgA antibodies targeting multiple antigens along the basement membrane zone, leading to disruption of dermoepidermal junction and development of bullous lesions which often presents in characteristic arrangement. Although most LABD cases have been reported to be idiopathic, different triggers have been described, including several drugs and infection. However, the occurrence of vaccine-induced cases of LABD is not widely known and accepted due to the few reports available. We present two cases of LABD occurred following different triggers, rising the suspicion for a possible pathogenetic role of vaccines.

scholarly journals 606 The role of diet in patients with autoimmune blistering disease: A survey of the International Pemphigus and Pemphigoid Foundation

2019 ◽  
Vol 139 (5) ◽  
pp. S104
Author(s):  
D.B. Kneiber ◽  
E. Kowalski ◽  
K. Kridin ◽  
M. Yale ◽  
S.A. Grando ◽  
...  
Keyword(s):  
Autoimmune Blistering Disease ◽  
Blistering Disease

scholarly journals Juvenile Bullous Pemphigoid – a Case Report

2013 ◽  
Vol 5 (1) ◽  
pp. 31-36
Author(s):  
Kristina Kostić ◽  
Lidija Kandolf Sekulović ◽  
Radoš D. Zečević
Keyword(s):  
Bullous Pemphigoid ◽  
White Cell Count ◽  
Direct Immunofluorescence ◽  
Elderly Persons ◽  
Dermoepidermal Junction ◽  
Autoimmune Blistering Disease ◽  
Systemic Corticosteroids ◽  
Laboratory Test Results ◽  
Intense Pruritus ◽  
Blistering Disease

Abstract Bullous pemphigoid is an autoimmune blistering disease that predominantly affects elderly persons and rarely children. We present a 12-year-old girl with sudden appearance of tense blisters on an erythematous base on the trunk, neck, hands and legs with intense pruritus. Standard laboratory test results were within the normal range except for blood eosinophilia of 12% of the total white cell count. Skin biopsy specimens showed evolving subepidermal blisters with perivascular lymphohistiocytic, eosinophil and neutrophil infiltrations in the papillary dermis. Direct immunofluorescence of perilesional skin showed linear, continuous deposits of IgG and C3 along the dermoepidermal junction. Indirect immunofluorescence showed circulating anti-basement membrane zone IgG autoantibodies at a titer of 1:80. We started treatment with systemic corticosteroids, methylprednisolone 0,5 mg/kg per day and 500 mg erythromycin 4 times a day during 10 days. After 3 days 50 mg dapsone (DDS, 4,4-diaminodiphenylsulphone) per day was added. After a few days, there were no new changes on the skin and pruritus disappeared completely.

scholarly journals Role of different pathways of the complement cascade in experimental bullous pemphigoid

2006 ◽  
Vol 116 (11) ◽  
pp. 2892-2900 ◽  
Author(s):  
Kelly C. Nelson ◽  
Minglang Zhao ◽  
Pamela R. Schroeder ◽  
Ning Li ◽  
Rick A. Wetsel ◽  
...  
Keyword(s):  
Bullous Pemphigoid ◽  
Complement Cascade

scholarly journals Bullous pemphigoid autoantibodies

2021 ◽  
Vol 5 (4) ◽  
pp. 259-263
Author(s):  
Florentina-Silvia Delli ◽  
◽  
Elena Sotiriou ◽  
Efstratios Vakirlis ◽  
Demetrios Ioannides
Keyword(s):  
Bullous Pemphigoid ◽  
Dermatitis Herpetiformis ◽  
Direct Immunofluorescence ◽  
Risk Of Death ◽  
Class Switch ◽  
Autoimmune Blistering Disease ◽  
Systemic Corticosteroids ◽  
First Choice ◽  
Blistering Disease ◽  
Blistering Skin Disorders

<abstract> <p>Autoimmune blistering skin disorders are rare. According to direct immunofluorescence studies, three categories are described: pemphigus group, pemphigoid group and dermatitis herpetiformis. Among these diseases, bullous pemphigoid is the most common. Patients with typical bullous pemphigoid disease are usually elderly and have many comorbidities. Considering that topical and systemic corticosteroids are the first choice therapy, these patients also have increased morbidity and risk of death. The main characteristic of bullous pemphigoid as an acquired autoimmune blistering disease is the formation of autoantibodies against hemidesmosomal antigens BP180 and BP230. Although IgG autoantibodies predominate within the plasma and skin of BP patients, some features of the disease cannot be explained solely by IgG-mediated mechanisms. Epitope spreading phenomena, immunoglobulin class switch and the relevance of IgM and IgE autoantibodies are discussed in this article.</p> </abstract>

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