scholarly journals Nucleocytosolic Acetyl-Coenzyme A Synthetase Is Required for Histone Acetylation and Global Transcription

2006 ◽  
Vol 23 (2) ◽  
pp. 207-217 ◽  
Author(s):  
Hidekazu Takahashi ◽  
J. Michael McCaffery ◽  
Rafael A. Irizarry ◽  
Jef D. Boeke
Keyword(s):  
Histone Acetylation ◽  
Coenzyme A ◽  
Acetyl Coenzyme A ◽  
Acetyl Coenzyme

scholarly journals Mitochondrial acetyl-CoA reversibly regulates locus-specific histone acetylation and gene expression

2019 ◽  
Vol 2 (1) ◽  
pp. e201800228 ◽  
Author(s):  
Oswaldo A Lozoya ◽  
Tianyuan Wang ◽  
Dagoberto Grenet ◽  
Taylor C Wolfgang ◽  
Mack Sobhany ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mitochondrial Dysfunction ◽  
Histone Acetylation ◽  
Coenzyme A ◽  
Specific Gene ◽  
Atp Citrate Lyase ◽  
Acetyl Coenzyme A ◽  
Mtdna Depletion ◽  
Acetyl Coenzyme ◽  
The Impact

The impact of mitochondrial dysfunction in epigenetics is emerging, but our understanding of this relationship and its effect on gene expression remains incomplete. We previously showed that acute mitochondrial DNA (mtDNA) loss leads to histone hypoacetylation. It remains to be defined if these changes are maintained when mitochondrial dysfunction is chronic and if they alter gene expression. To fill these gaps of knowledge, we here studied a progressive and a chronic model of mtDNA depletion using biochemical, pharmacological, genomics, and genetic assays. We show that histones are primarily hypoacetylated in both models. We link these effects to decreased histone acetyltransferase activity unrelated to changes in ATP citrate lyase, acetyl coenzyme A synthetase 2, or pyruvate dehydrogenase activities, which can be reversibly modulated by altering the mitochondrial pool of acetyl-coenzyme A. Also, we determined that the accompanying changes in histone acetylation regulate locus-specific gene expression and physiological outcomes, including the production of prostaglandins. These results may be relevant to the pathophysiology of mtDNA depletion syndromes and to understanding the effects of environmental agents that lead to physical or functional mtDNA loss.

scholarly journals Acetyl Coenzyme A Carboxylase

1969 ◽  
Vol 244 (22) ◽  
pp. 6254-6262 ◽  
Author(s):  
Philip W. Majerus ◽  
Elisabeth Kilburn
Keyword(s):  
Coenzyme A ◽  
Acetyl Coenzyme A ◽  
Acetyl Coenzyme ◽  
Acetyl Coenzyme A Carboxylase
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