scholarly journals Perinatal exposure to bisphenol A modifies the transcriptional regulation of the β-Casein gene during secretory activation of the rat mammary gland

2017 ◽  
Vol 439 ◽  
pp. 407-418 ◽  
Author(s):  
Gabriela A. Altamirano ◽  
Jorge G. Ramos ◽  
Ayelen L. Gomez ◽  
Enrique H. Luque ◽  
Monica Muñoz-de-Toro ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Mammary Gland ◽  
Bisphenol A ◽  
Perinatal Exposure ◽  
Casein Gene ◽  
Secretory Activation ◽  
Rat Mammary Gland

scholarly journals Perinatal Exposure to Bisphenol A Increases Adult Mammary Gland Progesterone Response and Cell Number

2011 ◽  
Vol 25 (11) ◽  
pp. 1915-1923 ◽  
Author(s):  
Ayyakkannu Ayyanan ◽  
Ouahiba Laribi ◽  
Sonia Schuepbach-Mallepell ◽  
Christina Schrick ◽  
Maria Gutierrez ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Bisphenol A ◽  
Cell Number ◽  
Perinatal Exposure

Bisphenol A and benzophenone-3 exposure alters milk protein expression and its transcriptional regulation during functional differentiation of the mammary gland in vitro

2020 ◽  
Vol 191 ◽  
pp. 110185
Author(s):  
Gabriela A. Altamirano ◽  
Ayelen L. Gomez ◽  
Gonzalo Schierano-Marotti ◽  
Mónica Muñoz-de-Toro ◽  
Horacio A. Rodriguez ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Mammary Gland ◽  
Bisphenol A ◽  
Protein Expression ◽  
Milk Protein ◽  
Functional Differentiation

Perinatal exposure to bisphenol A impacts in the mammary gland morphology of adult Mongolian gerbils

2020 ◽  
Vol 113 ◽  
pp. 104374
Author(s):  
Ellen Cristina Rivas Leonel ◽  
Silvana Gisele Pegorin Campos ◽  
Carolina Marques Baraldi Bedolo ◽  
Luiz Henrique Alves Guerra ◽  
Patrícia Simone Leite Vilamaior ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Bisphenol A ◽  
Perinatal Exposure ◽  
Mongolian Gerbils ◽  
Mammary Gland Morphology

scholarly journals Perinatal Exposure to Bisphenol-A Alters Peripubertal Mammary Gland Development in Mice

Endocrinology ◽  
2005 ◽  
Vol 146 (9) ◽  
pp. 4138-4147 ◽  
Author(s):  
Monica Muñoz-de-Toro ◽  
Caroline M. Markey ◽  
Perinaaz R. Wadia ◽  
Enrique H. Luque ◽  
Beverly S. Rubin ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Bisphenol A ◽  
Dental Materials ◽  
Perinatal Exposure ◽  
Terminal End Buds ◽  
Branching Points ◽  
Food And Beverage ◽  
Estrogenic Chemicals ◽  
Gland Morphogenesis ◽  
Apoptotic Activity

Abstract Developmental exposure to estrogenic chemicals induces morphological, functional, and behavioral anomalies associated with reproduction. Humans are exposed to bisphenol-A (BPA), an estrogenic compound that leaches from dental materials and plastic food and beverage containers. The aim of the present study was to determine the effects of perinatal exposure to low, environmentally relevant doses of BPA [25 and 250 ng BPA/kg body weight (bw)·d] on the peripubertal development of the mammary gland. BPA exposure enhanced the mammary glands’ sensitivity to estradiol in ovariectomized CD-1 mice. In their intact 30-d-old littermates, the area and numbers of terminal end buds relative to the gland ductal area increased whereas their apoptotic activity decreased. There was a positive correlation between ductal length and the age at first proestrus; that was reduced as the BPA dose increased, suggesting that BPA exposure slows down ductal invasion of the stroma. There was also a significant increase of progesterone receptor-positive ductal epithelial cells that were localized in clusters, suggesting future branching points. Indeed, lateral branching was significantly enhanced at 4 months of age in mice exposed to 25 ng BPA /kg bw·d. In conclusion, perinatal exposure to environmentally relevant BPA doses results in persistent alterations in mammary gland morphogenesis. Of special concern is the increased terminal end bud density at puberty as well as the increased number of terminal ends reported previously in adult animals, as these two structures are the sites at which cancer arises in humans and rodents.

scholarly journals Perinatal Exposure to Bisphenol A or Diethylstilbestrol Increases the Susceptibility to Develop Mammary Gland Lesions After Estrogen Replacement Therapy in Middle-Aged Rats

2017 ◽  
Vol 8 (2) ◽  
pp. 78-89 ◽  
Author(s):  
Ayelen L. Gomez ◽  
Melisa B. Delconte ◽  
Gabriela A. Altamirano ◽  
Lucia Vigezzi ◽  
Veronica L. Bosquiazzo ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Bisphenol A ◽  
Replacement Therapy ◽  
Estrogen Replacement Therapy ◽  
Perinatal Exposure ◽  
Aged Rats ◽  
Estrogen Replacement ◽  
Middle Aged

Pseudophosphorylated prolactin (S179D PRL) inhibits growth and promotes β-casein gene expression in the rat mammary gland

2002 ◽  
Vol 309 (3) ◽  
pp. 429-437 ◽  
Author(s):  
Benson Kuo ◽  
Wei Wu ◽  
Xiaolei Xu ◽  
Lili Yang ◽  
Cyndi Chen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mammary Gland ◽  
Casein Gene ◽  
Rat Mammary Gland

Prenatal Bisphenol A exposure delays the development of the male rat mammary gland

2015 ◽  
Vol 54 ◽  
pp. 37-46 ◽  
Author(s):  
Laura Kass ◽  
Milena Durando ◽  
Gabriela A. Altamirano ◽  
Gisela E. Manfroni-Ghibaudo ◽  
Enrique H. Luque ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Bisphenol A ◽  
Male Rat ◽  
Rat Mammary Gland
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