scholarly journals Perinatal Exposure to Bisphenol A Increases Adult Mammary Gland Progesterone Response and Cell Number

2011 ◽  
Vol 25 (11) ◽  
pp. 1915-1923 ◽  
Author(s):  
Ayyakkannu Ayyanan ◽  
Ouahiba Laribi ◽  
Sonia Schuepbach-Mallepell ◽  
Christina Schrick ◽  
Maria Gutierrez ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Bisphenol A ◽  
Cell Number ◽  
Perinatal Exposure

Perinatal exposure to bisphenol A impacts in the mammary gland morphology of adult Mongolian gerbils

2020 ◽  
Vol 113 ◽  
pp. 104374
Author(s):  
Ellen Cristina Rivas Leonel ◽  
Silvana Gisele Pegorin Campos ◽  
Carolina Marques Baraldi Bedolo ◽  
Luiz Henrique Alves Guerra ◽  
Patrícia Simone Leite Vilamaior ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Bisphenol A ◽  
Perinatal Exposure ◽  
Mongolian Gerbils ◽  
Mammary Gland Morphology

scholarly journals Perinatal Exposure to Bisphenol-A Alters Peripubertal Mammary Gland Development in Mice

Endocrinology ◽  
2005 ◽  
Vol 146 (9) ◽  
pp. 4138-4147 ◽  
Author(s):  
Monica Muñoz-de-Toro ◽  
Caroline M. Markey ◽  
Perinaaz R. Wadia ◽  
Enrique H. Luque ◽  
Beverly S. Rubin ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Bisphenol A ◽  
Dental Materials ◽  
Perinatal Exposure ◽  
Terminal End Buds ◽  
Branching Points ◽  
Food And Beverage ◽  
Estrogenic Chemicals ◽  
Gland Morphogenesis ◽  
Apoptotic Activity

Abstract Developmental exposure to estrogenic chemicals induces morphological, functional, and behavioral anomalies associated with reproduction. Humans are exposed to bisphenol-A (BPA), an estrogenic compound that leaches from dental materials and plastic food and beverage containers. The aim of the present study was to determine the effects of perinatal exposure to low, environmentally relevant doses of BPA [25 and 250 ng BPA/kg body weight (bw)·d] on the peripubertal development of the mammary gland. BPA exposure enhanced the mammary glands’ sensitivity to estradiol in ovariectomized CD-1 mice. In their intact 30-d-old littermates, the area and numbers of terminal end buds relative to the gland ductal area increased whereas their apoptotic activity decreased. There was a positive correlation between ductal length and the age at first proestrus; that was reduced as the BPA dose increased, suggesting that BPA exposure slows down ductal invasion of the stroma. There was also a significant increase of progesterone receptor-positive ductal epithelial cells that were localized in clusters, suggesting future branching points. Indeed, lateral branching was significantly enhanced at 4 months of age in mice exposed to 25 ng BPA /kg bw·d. In conclusion, perinatal exposure to environmentally relevant BPA doses results in persistent alterations in mammary gland morphogenesis. Of special concern is the increased terminal end bud density at puberty as well as the increased number of terminal ends reported previously in adult animals, as these two structures are the sites at which cancer arises in humans and rodents.

scholarly journals Perinatal exposure to bisphenol A modifies the transcriptional regulation of the β-Casein gene during secretory activation of the rat mammary gland

2017 ◽  
Vol 439 ◽  
pp. 407-418 ◽  
Author(s):  
Gabriela A. Altamirano ◽  
Jorge G. Ramos ◽  
Ayelen L. Gomez ◽  
Enrique H. Luque ◽  
Monica Muñoz-de-Toro ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Mammary Gland ◽  
Bisphenol A ◽  
Perinatal Exposure ◽  
Casein Gene ◽  
Secretory Activation ◽  
Rat Mammary Gland

scholarly journals Perinatal Exposure to Bisphenol A or Diethylstilbestrol Increases the Susceptibility to Develop Mammary Gland Lesions After Estrogen Replacement Therapy in Middle-Aged Rats

2017 ◽  
Vol 8 (2) ◽  
pp. 78-89 ◽  
Author(s):  
Ayelen L. Gomez ◽  
Melisa B. Delconte ◽  
Gabriela A. Altamirano ◽  
Lucia Vigezzi ◽  
Veronica L. Bosquiazzo ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Bisphenol A ◽  
Replacement Therapy ◽  
Estrogen Replacement Therapy ◽  
Perinatal Exposure ◽  
Aged Rats ◽  
Estrogen Replacement ◽  
Middle Aged

Proteomic Basis for the Increased Susceptibility of the Mammary Gland to Carcinogenesis After Perinatal Exposure to Bisphenol A

2011 ◽  
pp. 103-125
Author(s):  
Sarah Jenkins ◽  
Angela M. Betancourt ◽  
Jun Wang ◽  
James A. Mobley ◽  
Coral A. Lamartiniere
Keyword(s):  
Mammary Gland ◽  
Bisphenol A ◽  
Perinatal Exposure ◽  
Increased Susceptibility

scholarly journals Prenatal Bisphenol A Exposure Induces Preneoplastic Lesions in the Mammary Gland in Wistar Rats

2007 ◽  
Vol 115 (1) ◽  
pp. 80-86 ◽  
Author(s):  
Milena Durando ◽  
Laura Kass ◽  
Julio Piva ◽  
Carlos Sonnenschein ◽  
Ana M. Soto ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Bisphenol A ◽  
Wistar Rats ◽  
Preneoplastic Lesions

scholarly journals Effects of Perinatal Exposure to Bisphenol A on Brain Neurotransmitters in Female Rat Offspring

2006 ◽  
Vol 44 (3) ◽  
pp. 510-524 ◽  
Author(s):  
Takeshi HONMA ◽  
Muneyuki MIYAGAWA ◽  
Megumi SUDA ◽  
Rui-Sheng WANG ◽  
Kenichi KOBAYASHI ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Perinatal Exposure ◽  
Female Rat ◽  
Rat Offspring ◽  
Brain Neurotransmitters

Effects of perinatal exposure to bisphenol A on the intraprostatic levels of aromatase and 5α-reductase isozymes in juvenile rats

2018 ◽  
Vol 115 ◽  
pp. 20-25 ◽  
Author(s):  
Beatriz Castro ◽  
Pilar Sánchez ◽  
Jesús M. Torres ◽  
Esperanza Ortega
Keyword(s):  
Bisphenol A ◽  
Perinatal Exposure ◽  
Juvenile Rats
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