Associations of steroid sex hormones and sex hormone-binding globulin with N-terminal pro-brain natriuretic peptide in postmenopausal women: The Rotterdam Study

Maturitas ◽  
2017 ◽  
Vol 100 ◽  
pp. 129
Author(s):  
Marija Glisic ◽  
Lyda Z. Rojas Sanchez ◽  
Eralda Asllanaj ◽  
Kris G. Vargas ◽  
Maryam Kavousi ◽  
...  
Keyword(s):  
Brain Natriuretic Peptide ◽  
Postmenopausal Women ◽  
Natriuretic Peptide ◽  
Sex Hormones ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Rotterdam Study ◽  
Hormone Binding ◽  
Steroid Sex Hormones

scholarly journals Sex Steroids, Sex Hormone-Binding Globulin and Cardiovascular Health in Men and Postmenopausal Women: The Rotterdam Study

2016 ◽  
Vol 101 (7) ◽  
pp. 2844-2852 ◽  
Author(s):  
Loes Jaspers ◽  
Klodian Dhana ◽  
Taulant Muka ◽  
Cindy Meun ◽  
Jessica C. Kiefte-de Jong ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Sex Steroids ◽  
Cardiovascular Health ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Rotterdam Study ◽  
Hormone Binding

scholarly journals Association of sex hormones and sex hormone–binding globulin with depressive symptoms in postmenopausal women

2012 ◽  
Vol 19 (8) ◽  
pp. 877-885 ◽  
Author(s):  
Laura A. Colangelo ◽  
Lynette L. Craft ◽  
Pamela Ouyang ◽  
Kiang Liu ◽  
Pamela J. Schreiner ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Postmenopausal Women ◽  
Sex Hormones ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding

Association of N-terminal pro B-type natriuretic peptide and sex hormone-binding globulin in non-obese peri- and postmenopausal women

2010 ◽  
Vol 411 (3-4) ◽  
pp. 280-284 ◽  
Author(s):  
Toshiyuki Yasui ◽  
Sumika Matsui ◽  
Ayako Saijo ◽  
Takashi Kaji ◽  
Satoshi Yamamoto ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Natriuretic Peptide ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding

Abstract P046: Sex Hormone Levels and 10-Year Change in N-Terminal Pro-Brain Natriuretic Peptide Among Men and Post-Menopausal Women: The Multi-Ethnic Study of Atherosclerosis (MESA)

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Wendy Ying ◽  
Di Zhao ◽  
Pamela Ouyang ◽  
Dhananjay Vaidya ◽  
Chiadi E Ndumele ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Sex Hormones ◽  
Strong Predictor ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Levels ◽  
Menopausal Women ◽  
Post Menopausal

Background: The risk of cardiovascular disease (CVD) differs between men and women, and sex hormones are thought to play a key role. N-terminal pro-brain natriuretic peptide (NT-proBNP) is a sensitive biomarker of ventricular wall stress and a strong predictor of incident cardiovascular disease (CVD) and heart failure (HF). It can thus be seen as an early marker of CVD. We evaluated whether sex hormones levels were associated with change in NT-proBNP concentrations over 10 years in MESA. Methods: We studied 2348 men and 2041 post-menopausal women. Serum testosterone (T), estradiol, dehydroepiandrosterone (DHEA), and sex hormone binding globulin (SHBG) were measured at Exam 1 (2000-02); free T and bioavailable T were calculated. NT-proBNP was measured by Roche assay at Exam 1, plus Exam 3 (2004-05) and/or Exam 5 (2010-12). Multivariable-adjusted linear mixed effects models were used to study associations between sex hormone levels and change in NT-proBNP over an approximately 10-year period. Results: Mean (SD) age (years) at baseline was 65 (9) for women and 62 (10) for men. Women had higher NT-proBNP than men (median 76.6 vs 37.1 pg/ml). Among women, after adjusting for demographic, socioeconomic, and CVD risk factors, higher total T, bioavailable T, and free T were independently associated with a greater increase in NT-proBNP over 10 years, whereas estradiol and SHBG were inversely associated with change in NT-proBNP ( Table ). When sex hormones were analyzed together in the same model, total T was positively associated and SHBG was inversely associated with change in NT-proBNP. In men, higher estradiol was associated with greater 10-year increase in NT-proBNP. These associations were preserved after excluding individuals with ejection fraction <50%. Conclusion: A more androgenic sex hormone profile in post-menopausal women and a more estrogenic profile in men were independently associated with 10-year change in NT-proBNP levels. Sex hormone patterns may thus explain in part sex differences in the development of CVD and HF.

Sign in / Sign up

Export Citation Format

Share Document