scholarly journals Interrelation Between Sex Hormones and Plasma Sex Hormone-Binding Globulin and Hemoglobin A1c in Healthy Postmenopausal Women

2009 ◽  
Vol 7 (3) ◽  
pp. 249-254 ◽  
Author(s):  
Gabrielle Page-Wilson ◽  
Alessandra C. Goulart ◽  
Kathryn M. Rexrode
Keyword(s):  
Postmenopausal Women ◽  
Sex Hormones ◽  
Hemoglobin A1c ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding

scholarly journals Association of sex hormones and sex hormone–binding globulin with depressive symptoms in postmenopausal women

2012 ◽  
Vol 19 (8) ◽  
pp. 877-885 ◽  
Author(s):  
Laura A. Colangelo ◽  
Lynette L. Craft ◽  
Pamela Ouyang ◽  
Kiang Liu ◽  
Pamela J. Schreiner ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Postmenopausal Women ◽  
Sex Hormones ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding

The Relationship between Sex Hormones, Sex Hormone Binding Globulin and Peripheral Artery Disease in Older Persons

2011 ◽  
pp. P1-338-P1-338
Author(s):  
Chiara Cattabiani ◽  
Gianpaolo Ceda ◽  
Fulvio Lauretani ◽  
Stefania Bandinelli ◽  
Giulia Schiavi ◽  
...  
Keyword(s):  
Sex Hormones ◽  
Peripheral Artery Disease ◽  
Older Persons ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Peripheral Artery ◽  
Artery Disease ◽  
The Relationship

scholarly journals Alcohol Consumption in Relation to Plasma Sex Hormones, Prolactin, and Sex Hormone–Binding Globulin in Premenopausal Women

2014 ◽  
Vol 23 (12) ◽  
pp. 2943-2953 ◽  
Author(s):  
Kelly A. Hirko ◽  
Donna Spiegelman ◽  
Walter C. Willett ◽  
Susan E. Hankinson ◽  
A. Heather Eliassen
Keyword(s):  
Alcohol Consumption ◽  
Sex Hormones ◽  
Premenopausal Women ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding

scholarly journals The Effect of Metformin vs Placebo on Sex Hormones in Canadian Cancer Trials Group MA.32

2020 ◽  
Author(s):  
Isabel Pimentel ◽  
Bingshu E Chen ◽  
Ana Elisa Lohmann ◽  
Marguerite Ennis ◽  
Jennifer Ligibel ◽  
...  
Keyword(s):  
Sex Hormones ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Phase Iii ◽  
Endocrine Treatment ◽  
Hormone Binding ◽  
Bioavailable Testosterone ◽  
Improved Outcomes ◽  
Neo Adjuvant Chemotherapy ◽  
Estradiol Levels

Abstract Background Metformin has been associated with lower breast cancer (BC) risk and improved outcomes in observational studies. Multiple biologic mechanisms have been proposed, including a recent report of altered sex hormones. We evaluated the effect of metformin on sex hormones in MA.32, a phase III trial of nondiabetic BC subjects who were randomly assigned to metformin or placebo. Methods We studied the subgroup of postmenopausal hormone receptor-negative BC subjects not receiving endocrine treatment who provided fasting blood at baseline and at 6 months after being randomly assigned. Sex hormone-binding globulin, bioavailable testosterone, and estradiol levels were assayed using electrochemiluminescence immunoassay. Change from baseline to 6 months between study arms was compared using Wilcoxon sum rank tests and regression models. Results 312 women were eligible (141 metformin vs 171 placebo); the majority of subjects in each arm had T1/2, N0, HER2-negative BC and had received (neo)adjuvant chemotherapy. Mean age was 58.1 (SD=6.9) vs 57.5 (SD=7.9) years, mean body mass index (BMI) was 27.3 (SD=5.5) vs 28.9 (SD=6.4) kg/m2 for metformin vs placebo, respectively. Median estradiol decreased between baseline and 6 months on metformin vs placebo (−5.7 vs 0 pmol/L; P < .001) in univariable analysis and after controlling for baseline BMI and BMI change (P < .001). There was no change in sex hormone-binding globulin or bioavailable testosterone. Conclusion Metformin lowered estradiol levels, independent of BMI. This observation suggests a new metformin effect that has potential relevance to estrogen sensitive cancers.

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