Dose-dependent effect of Resveratrol on bladder cancer cells: Chemoprevention and oxidative stress

Maturitas ◽  
2012 ◽  
Vol 72 (1) ◽  
pp. 72-78 ◽  
Author(s):  
Bianca Stocco ◽  
Karina Toledo ◽  
Mirian Salvador ◽  
Michele Paulo ◽  
Natália Koyama ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Bladder Cancer ◽  
Cancer Cells ◽  
Dependent Effect ◽  
Bladder Cancer Cells ◽  
Dose Dependent ◽  
Dose Dependent Effect ◽  
And Oxidative Stress

scholarly journals A dose-dependent effect of dimethyl sulfoxide on lipid content, cell viability and oxidative stress in 3T3-L1 adipocytes

2018 ◽  
Vol 5 ◽  
pp. 1014-1020 ◽  
Author(s):  
Phiwayinkosi V. Dludla ◽  
Babalwa Jack ◽  
Amsha Viraragavan ◽  
Carmen Pheiffer ◽  
Rabia Johnson ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Viability ◽  
Dimethyl Sulfoxide ◽  
Lipid Content ◽  
Dependent Effect ◽  
Dose Dependent ◽  
Dose Dependent Effect ◽  
And Oxidative Stress

792: Role of Oxidative Stress in Tumorigenic Potential of Bladder Cancer Cells

2005 ◽  
Vol 173 (4S) ◽  
pp. 214-215 ◽  
Author(s):  
Daniel Cho ◽  
Xiao Fang Ha ◽  
J. Andre Melendez ◽  
Louis J. Giorgi ◽  
Badar M. Mian
Keyword(s):  
Oxidative Stress ◽  
Bladder Cancer ◽  
Cancer Cells ◽  
Tumorigenic Potential ◽  
Bladder Cancer Cells

Dose-Dependent Effect of Ethanol on Hepatic Oxidative Stress and Interleukin-6 Production After Burn Injury in the Mouse

2000 ◽  
Vol 24 (9) ◽  
pp. 1443-1448 ◽  
Author(s):  
Alessandra Colantoni ◽  
Lisa A. Duffner ◽  
Nicola Maria ◽  
Christine V. Fontanilla ◽  
Kelly A. N. Messingham ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Interleukin 6 ◽  
Burn Injury ◽  
Dependent Effect ◽  
Hepatic Oxidative Stress ◽  
Dose Dependent ◽  
Dose Dependent Effect

scholarly journals Oxidative Stress Sensitizes Bladder Cancer Cells to TRAIL Mediated Apoptosis by Down-Regulating Anti-Apoptotic Proteins

2009 ◽  
Vol 182 (3) ◽  
pp. 1178-1185 ◽  
Author(s):  
Shai J. White-Gilbertson ◽  
Laura Kasman ◽  
John McKillop ◽  
Tejas Tirodkar ◽  
Ping Lu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Bladder Cancer ◽  
Cancer Cells ◽  
Bladder Cancer Cells ◽  
Apoptotic Proteins

scholarly journals Antitumor Effect of IL-2 and TRAIL Proteins Expressed by Recombinant Salmonella in Murine Bladder Cancer Cells

2021 ◽  
Vol 55 (4) ◽  
pp. 460-476
Keyword(s):  
Oxidative Stress ◽  
Bladder Cancer ◽  
Cell Membrane ◽  
Cell Viability ◽  
Cancer Cells ◽  
Cell Morphology ◽  
Antitumor Effect ◽  
Interleukin 2 ◽  
Continuous Increase ◽  
Bladder Cancer Cells

Background/Aims: Cancer is the second most deadly disease in the world. The bladder cancer is one of the most aggressive types and shows a continuous increase in the number of cases. The use of bacteria as live vectors to deliver molecules directly to the tumor is a promising tool and has been used as an adjuvant treatment against several types of cancer. The aim of this study was to investigate the antitumor effect of Interleukin 2 (IL-2), TNF-related apoptosis-inducing ligand (TRAIL) and protein MIX against murine bladder cancer cells, lineage MB49. Methods: The attenuated Salmonella strain SL3261 was transformed by inserting the IL-2 and TRAIL genes. The effects of proteins on cell viability (MTT method), cell morphology (optical microscopy), cell recovery (clonogenic assay), cell membrane (lactate dehydrogenase release - LDH), on oxidative stress pathway (levels of nitric oxide, NO) and apoptosis (flow cytometry and high resolution epifluorescence images) were evaluated at intervals of 24 and 48 hours of action. Results: The results showed that there was a decrease in cell viability via damage to the cell membrane, alteration of cell morphology, non-recovery of cells, increase in the production of NO and incubate for of cells in the state of apoptosis in the two periods analyzed. Conclusion: The data presented suggest that IL-2, TRAIL and their MIX proteins in MB49 cells have cytotoxic potential and that this is associated with oxidative stress and apoptosis pathways. These results may contribute to the development of new therapeutic strategies for bladder cancer.

scholarly journals Oxidative Stress Plays an Important Role in Zoledronic Acid-Induced Autophagy

2014 ◽  
pp. S601-S612 ◽  
Author(s):  
V. K. M. KHANDELWAL ◽  
L. M. MITROFAN ◽  
J. M. T. HYTTINEN ◽  
K. R. CHAUDHARI ◽  
R. BUCCIONE ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Zoledronic Acid ◽  
Cancer Cells ◽  
Mevalonate Pathway ◽  
Continuous Treatment ◽  
Autophagy Induction ◽  
Anti Cancer ◽  
Dose Dependent ◽  
And Oxidative Stress ◽  
Mcf 7

Several pre-clinical and clinical studies have demonstrated zoledronic acid (Zol), which regulates the mevalonate pathway, has efficient anti-cancer effects. Zol can also induce autophagy. The aim of this study is to add new understanding to the mechanism of autophagy induction by Zol. LC3B-II, the marker for autophagy was increased by Zol treatment in breast cancer cells. Autophagosomes induced by Zol were visualized and quantified in both transient (pDendra2-hLC3) and stable MCF-7-GFP-LC3 cell lines. Acidic vesicular organelles were quantified using acridine orange. Zol induced a dose and time dependent autophagy. Treatment of Zol increased oxidative stress in MCF-7 cells, which was reversed by GGOH or anti-oxidants. On the other hand, treatment with GGOH or anti-oxidants resulted in decreased levels of LC3B-II. Further, the induced autophagy was irreversible, as the washout of Zol after 2 h or 24 h resulted in similar levels of autophagy, as induced by continuous treatment after 72 h. Thus, it can be summarized that Zol can induce a dose dependent but irreversible autophagy, by its effect on the mevalonate pathway and oxidative stress. This study adds to the understanding of the mechanism of action of Zol, and that it can induce autophagy at clinically relevant shorter exposure times in cancer cells.

Ailanthone increases oxidative stress in CDDP-resistant ovarian and bladder cancer cells by inhibiting of Nrf2 and YAP expression through a post-translational mechanism

2020 ◽  
Vol 150 ◽  
pp. 125-135 ◽  
Author(s):  
Marie Angèle Cucci ◽  
Margherita Grattarola ◽  
Chiara Dianzani ◽  
Giovanna Damia ◽  
Francesca Ricci ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Bladder Cancer ◽  
Cancer Cells ◽  
Bladder Cancer Cells

Dose-dependent effect of 2-deoxy-D-glucose on glycoprotein mannosylation in cancer cells

IUBMB Life ◽  
2015 ◽  
Vol 67 (3) ◽  
pp. 218-226 ◽  
Author(s):  
Aysel Ahadova ◽  
Johannes Gebert ◽  
Magnus von Knebel Doeberitz ◽  
Juergen Kopitz ◽  
Matthias Kloor
Keyword(s):  
Cancer Cells ◽  
Dependent Effect ◽  
Dose Dependent ◽  
Dose Dependent Effect

Biphasic Dose-Dependent Effect of Lithium Chloride on Survival of Human Hormone-Dependent Breast Cancer Cells (MCF-7)

2012 ◽  
Vol 150 (1-3) ◽  
pp. 477-486 ◽  
Author(s):  
Muralidharan Suganthi ◽  
Gopalakrishnan Sangeetha ◽  
Govindaraj Gayathri ◽  
Bhaskaran Ravi Sankar
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Lithium Chloride ◽  
Breast Cancer Cells ◽  
Dependent Effect ◽  
Dose Dependent ◽  
Dose Dependent Effect ◽  
Mcf 7
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